12 terminated. 12 Phase 2, 7 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Terminated 12 |
| Phase 1 | 7 | Terminated 7 |
Follow Medulloblastoma: new trials by email Literature Review of Medulloblastoma trials Research Report on Medulloblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma Sonidegib, Cisplatin, Lomustine - Medulloblastoma | Phase 2 | Terminated | European Organisation for Research and Treatment of Cancer - EORTC | 20 | 2022-11-11 | 2025-10-23 |
| 177Lu-DTPA-Omburtamab Radioimmunotherapy for Recurrent or Refractory Medulloblastoma 177Lu-DTPA-omburtamab - Medulloblastoma, Childhood | Phase 1 / Phase 2 | Terminated | Y-mAbs Therapeutics | 2 | 2021-09-30 | 2023-10-06 |
| A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in Children, Adolescents and Young Adults With Recurrent or Treatment-resistant Cancer Nivolumab, NKTR-214 - Ependymoma, Ewing Sarcoma | Phase 1 / Phase 2 | Terminated | Bristol-Myers Squibb | 15 | 2021-06-03 | 2023-03-24 |
| Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery CX 4945 - Medulloblastoma, Childhood, Medulloblastoma Recurrent | Phase 1 / Phase 2 | Terminated | Pediatric Brain Tumor Consortium | 21 | 2019-07-25 | 2026-10-19 |
| Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers Nivolumab, EKG, MRI Brain and/or spine - Medulloblastoma, Ependymoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 136 | 2017-07-13 | 2026-10-27 |
| Study of Genistein in Pediatric Oncology Patients (UVA-Gen001) Genistein, Placebo - Lymphoma, Childhood Lymphoma | Phase 2 | Terminated | University of Virginia | 4 | 2016-08-01 | 2024-05-06 |
| Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors Intra thecal methotrexate, topotecan, cyclophosphamide - Recurrent Childhood Medulloblastoma, Recurrent Childhood Ependymoma | Phase 2 | Terminated | Nicklaus Children's Hospital f/k/a Miami Children's Hospital | 3 | 2016-02-01 | 2020-01-10 |
| Phase I/II: Decitabine/Vaccine Therapy in Relapsed/Refractory Pediatric High Grade Gliomas/Medulloblastomas/CNS PNETs Vaccine (autologous dendritic cells), Decitabine and Hiltonol - Gliomas, Medulloblastoma | Phase 1 / Phase 2 | Terminated | University of Louisville | 1 | 2015-04-01 | 2018-05-04 |
| Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway vismodegib, Temozolomide - Histologically Confirmed Medulloblastoma, Activation of the Sonic Hedgehog (SHH) Pathway | Phase 1 / Phase 2 | Terminated | Centre Leon Berard | 24 | 2012-06-01 | 2019-05-21 |
| Safety and Efficacy Study of TPI-287 in Neuroblastoma and Medulloblastoma TPI 287 - Neuroblastoma, Medulloblastoma | Phase 1 / Phase 2 | Terminated | Giselle Sholler | 8 | 2011-12-01 | 2024-08-06 |
| Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors carboplatin, dasatinib, etoposide phosphate - Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor | Phase 1 / Phase 2 | Terminated | City of Hope Medical Center | 7 | 2008-09-03 | 2023-07-14 |
| Low-Dose Radiation and Combination Chemotherapy Following Surgery in Children With Newly Diagnosed Medulloblastoma Cisplatin, Cyclophosphamide, Etoposide - Brain Tumors, Central Nervous System Tumors | Phase 2 | Terminated | Children's Hospital of Philadelphia | 30 | 2001-04-01 | 2019-04-25 |
Neuroblastoma (4) · Brain Neoplasms (3) · Ependymoma (3) · Lymphoma (3) · Neuroectodermal Tumors, Primitive (3) · Central Nervous System Neoplasms (2) · Choroid Plexus Neoplasms (2) · Familial ependymoma (2) · Glioma (2) · Lymphoma, Non-Hodgkin (2) · Microphthalmia, Isolated, with Coloboma 5 (2) · Neoplasms (2) · Recurrence (2) · Rhabdoid Tumor (2)
Neoplasms by Histologic Type (12) · Neoplasms, Glandular and Epithelial (12) · Neoplasms, Nerve Tissue (12) · Neoplasms, Neuroepithelial (12) · Neuroectodermal Tumors (12) · Neoplasms, Germ Cell and Embryonal (11) · Glioma (10) · Neoplasms (10) · Neuroectodermal Tumors, Primitive (9) · Neoplasms by Site (6) · Nervous System Diseases (5) · Nervous System Neoplasms (5) · Brain Diseases (4) · Central Nervous System Diseases (4) · Central Nervous System Neoplasms (3)
Cisplatin (2) · Cyclophosphamide (2) · Lomustine (2) · Nivolumab (2) · Radiotherapy (2) · Vincristine (2) · Blotting, Western (1) · Carboplatin (1) · Dasatinib (1) · Decitabine (1) · Electrocardiography (1) · Etoposide (1) · Genistein (1) · HhAntag691 (1) · Ifosfamide (1)
Bristol-Myers Squibb (1) · Centre Leon Berard (1) · Children's Hospital of Philadelphia (1) · City of Hope Medical Center (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Giselle Sholler (1) · National Cancer Institute (NCI) (1) · Nicklaus Children's Hospital f/k/a Miami Children's Hospital (1) · Pediatric Brain Tumor Consortium (1) · University of Louisville (1) · University of Virginia (1) · Y-mAbs Therapeutics (1)
United States (10) · France (3) · Italy (3) · Spain (3) · Australia (2) · Germany (2) · Netherlands (2) · Switzerland (2) · United Kingdom (2) · Austria (1) · Denmark (1)
Giselle Sholler, MD (1) · Judith K. Sato, MD (1) · Kenneth G Lucas, MD (1) · Kevin Camphausen, M.D. (1) · Nehal Parikh, MD (1) · Peter C. Phillips, MD (1) · Peter Hau (1) · Ralph Salloum, MD (1) · William C. Petersen, Jr., M.D. (1) · Ziad Khatib, MD (1)
PMID 18447671, PMID 34171339, PMID 34540703, PMID 40721826
P30CA033572 (1), UM1CA081457 (1)