8 completed, 1 suspended. 4 Not applicable, 2 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 3, Suspended 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Masticatory Muscles, Hypertrophy of: new trials by email Literature Review of Masticatory Muscles, Hypertrophy of trials Research Report on Masticatory Muscles, Hypertrophy of
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Dry Needling and Two Botulinum Toxins for Bruxism Dry Needling (DN), PrabotulinumtoxinA, Abobotulinumtoxina - Bruxism, Sleep Bruxism, Adult | Not applicable | Completed | Recep Tayyip Erdogan University | 72 | 2026-01-09 | 2026-05-20 |
| Changes in Electromyographic Activity in Aligner Treatment of Adult Patients With and Without Nocturnal Bruxism Bruxoff ® - Sleep Bruxism, Masseter Muscle Hypertrophy | Not applicable | Suspended | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 22 | 2025-10-31 | 2025-08-27 |
| Ultrasonographic Evaluation of Masseter Muscle Changes After Botulinum Toxin Injection in Bruxism Patients Botulinum Toxin A (Botox ) - Bruxism, Myofascial Pain | Not applicable | Completed | Kahramanmaras Sutcu Imam University | 17 | 2025-09-30 | 2026-04-22 |
| Investigating the Effects of Smartphone Use on the Masseter Muscle Smartphone Addiction, Masseter Muscle Hypertrophy | Completed | Bandırma Onyedi Eylül University | 105 | 2024-07-01 | 2025-06-06 | |
| Effect of Different Treatment Techniques on Masseter Muscle Thickness Occlusal splint, preventive advice, Botulinum toxin - Bruxism, Masseter Muscle Hypertrophy | Not applicable | Completed | Zonguldak Bulent Ecevit University | 48 | 2023-04-03 | 2024-09-19 |
| MEDITOXIN® Treatment in Subject With Benign Masseteric Hypertrophy Meditoxin, Placebo - Masseter Muscle Hypertrophy | Phase 3 | Completed | Medy-Tox | 180 | 2018-04-09 | 2020-07-28 |
| Xeomin Cosmetic in the Management of Masseter Xeomin Cosmetic - Masseter Muscle Hypertrophy | Phase 4 | Completed | Erevna Innovations Inc. | 30 | 2015-11-06 | 2017-12-18 |
| Medytoxin® Treatment in Patients With Benign Masseteric Hypertrophy Botulinum Toxin Type A, Placebos - Hypertrophy of Masseter Muscle | Phase 2 | Completed | Medy-Tox | 69 | 2014-10-06 | 2019-03-27 |
| Botulinum Toxin Type A (BOTOX®) Treatment of Masseter Muscle Hypertrophy botulinum toxin Type A, Normal saline - Masseter Muscle Hypertrophy | Phase 2 | Completed | Allergan | 187 | 2014-01-20 | 2019-05-28 |
Bruxism (4) · Sleep Bruxism (2) · Internet Addiction Disorder (1) · Myalgia (1) · Temporomandibular Joint Disorders (1) · Trismus (1)
Behavior (5) · Habits (4) · Stomatognathic Diseases (4) · Tooth Diseases (4) · Nervous System Diseases (3) · Mental Disorders (2) · Muscular Diseases (2) · Musculoskeletal Diseases (2) · Neurologic Manifestations (2) · Parasomnias (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Sleep Wake Disorders (2) · Behavior, Addictive (1) · Compulsive Behavior (1)
Botulinum Toxins, Type A (5) · Saline Solution (2) · Botulinum Toxins (1) · Dry Needling (1) · Mouth Protectors (1) · Occlusal Splints (1) · abobotulinumtoxinA (1) · prabotulinumtoxin A (1)
Medy-Tox (2) · Allergan (1) · Bandırma Onyedi Eylül University (1) · Erevna Innovations Inc. (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Kahramanmaras Sutcu Imam University (1) · Recep Tayyip Erdogan University (1) · Zonguldak Bulent Ecevit University (1)
Turkey (Türkiye) (4) · South Korea (2) · Australia (1) · Canada (1) · Italy (1) · Taiwan (1)
Andreas Nikolis, MD (1) · Beom Joon Kim, Ph D (1) · Beta Bowen (1) · Massimo Cordaro, professor (1)
PMID 16541841, PMID 18557915, PMID 24374575, PMID 24417585, PMID 24482784, PMID 25367475, PMID 29589157, PMID 31261634, PMID 31480550, PMID 31831164, PMID 40935351, PMID 42579291