13 active not recruiting, 10 completed, 5 terminated, 4 recruiting. 36 Phase 1, 11 Phase 2.
Follow Malignant Solid Neoplasm: new trials by email Literature Review of Malignant Solid Neoplasm trials Research Report on Malignant Solid Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cannabis Gummy for the Improvement of Sleep and Quality of Life in Patients With Cancer, Pillow Trial Actigraphy, Best Practice, Biospecimen Collection - Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm | Phase 1 / Phase 2 | Not yet recruiting | Theodore Brasky PhD | 50 | 2027-01-15 | 2026-10-14 |
| Evaluating the Effects of Propionate and Butyrate Supplementation on the Intestinal Health of Healthy Volunteers Biospecimen Collection, Microencapsulated Sodium Butyrate, Microencapsulated Sodium Propionate - Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm | Phase 1 | Not yet recruiting | City of Hope Medical Center | 12 | 2026-09-30 | 2026-05-28 |
| Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers Computed Tomography, Fludeoxyglucose F-18, Gallium Ga 68 FAPi-46 - Anal Carcinoma, Bladder Carcinoma | Phase 1 | Active not recruiting | Jonsson Comprehensive Cancer Center | 30 | 2025-08-01 | 2026-10-20 |
| Interstitial Photodynamic Therapy Following Palliative Radiotherapy in Treating Patients With Inoperable Malignant Central Airway Obstruction Biospecimen Collection, Computed Tomography, Endobronchial Ultrasound Bronchoscopy - Malignant Solid Neoplasm | Phase 1 / Phase 2 | Recruiting | Roswell Park Cancer Institute | 42 | 2024-10-01 | 2026-04-06 |
| Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus Specific CTL Lines for Viral Infections in Immunosuppressed Cancer Patients Virus-specific Cytotoxic T-lymphocytes - Adenovirus Infection, BK Virus Infection | Phase 1 | Terminated | M.D. Anderson Cancer Center | 12 | 2023-01-06 | 2026-08-11 |
| Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors Atezolizumab, Biospecimen Collection, Computed Tomography - Atypical Teratoid/Rhabdoid Tumor, Epithelioid Sarcoma | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 86 | 2022-11-17 | 2026-07-14 |
| Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain Psilocybin, Psychotherapy, Quality-of-Life Assessment - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Phase 1 | Completed | Emory University | 11 | 2022-11-01 | 2025-07-23 |
| Development of a Digital Tool, MyInspiration, for the Improvement of Spiritual Well-Being in Patients with Cancer Internet-Based Intervention - Malignant Solid Neoplasm | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 52 | 2022-07-01 | 2024-10-08 |
| Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax Atezolizumab, Cabozantinib S-malate, Nab-paclitaxel - Advanced Breast Carcinoma, Advanced Endometrial Carcinoma | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 43 | 2022-04-29 | 2026-07-16 |
| 64Cu-DOTA-pembrolizumab PET for the Study of PD1 Expression Copper Cu 64-DOTA-pembrolizumab, Pembrolizumab, Positron Emission Tomography - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Phase 1 | Withdrawn | City of Hope Medical Center | 2022-04-15 | 2026-08-12 | |
| Pharmacokinetics of Sotrovimab as Pre-exposure Prophylaxis for COVID-19 in Hematopoietic Stem Cell Transplant Recipients, COVIDMAB Study Questionnaire Administration, Sotrovimab, Biospecimen Collection - COVID-19 Infection, Hematopoietic and Lymphoid Cell Neoplasm | Phase 1 | Terminated | Fred Hutchinson Cancer Center | 20 | 2022-01-25 | 2025-02-13 |
| Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread Atezolizumab, Carboplatin, Entinostat - Extensive Stage Lung Small Cell Carcinoma, Malignant Solid Neoplasm | Phase 1 | Completed | National Cancer Institute (NCI) | 3 | 2021-04-27 | 2025-10-03 |
| Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer Best Practice, Biospecimen Collection, Endoscopic Procedure - Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8 | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 800 | 2021-02-21 | 2026-07-15 |
| Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy Best Practice, Leflunomide, Placebo Administration - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Phase 1 / Phase 2 | Completed | City of Hope Medical Center | 2 | 2021-01-07 | 2024-07-03 |
| Rintatolimod and IFN Alpha-2b for the Treatment of COVID-19 in Cancer Patients Recombinant Interferon Alfa-2b, Rintatolimod - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Phase 1 / Phase 2 | Terminated | Roswell Park Cancer Institute | 4 | 2020-11-17 | 2026-01-13 |
| Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization Best Practice, Ibrutinib - Aplastic Anemia, Hematopoietic and Lymphoid Cell Neoplasm | Phase 1 | Completed | Jennifer Woyach | 10 | 2020-10-23 | 2023-12-26 |
| Alisertib and Pembrolizumab for the Treatment of Patients With Rb-deficient Head and Neck Squamous Cell Cancer Alisertib, Pembrolizumab - Head and Neck Squamous Cell Carcinoma, Malignant Solid Neoplasm | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 24 | 2020-09-15 | 2025-05-20 |
| Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers Computed Tomography, Gallium Ga 68 FAPi-46, Positron Emission Tomography - Bladder Carcinoma, Cervical Carcinoma | Phase 1 | Active not recruiting | Jonsson Comprehensive Cancer Center | 26 | 2020-08-27 | 2026-02-05 |
| Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia Best Practice, Mesenchymal Stem Cell - COVID-19 Infection, COVID-19-Associated Acute Respiratory Distress Syndrome | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 65 | 2020-07-29 | 2026-10-05 |
| Donor Bone Marrow Derived Mesenchymal Stem Cells in Controlling Heart Failure in Patients With Cardiomyopathy Caused by Anthracyclines Best Practice, Laboratory Biomarker Analysis, Mesenchymal Stem Cell Transplantation - Cardiomyopathy, Heart Failure | Phase 1 | Suspended | M.D. Anderson Cancer Center | 72 | 2020-07-18 | 2026-08-03 |
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Hematologic Neoplasms (14) · Brain Neoplasms (5) · Breast Neoplasms (4) · Carcinoma, Non-Small-Cell Lung (4) · Urogenital Neoplasms (4) · Carcinoma, Hepatocellular (3) · Urinary Bladder Neoplasms (3) · Adrenal Gland Neoplasms (2) · COVID-19 (2) · Carcinoma, Renal Cell (2) · Carcinoma, Transitional Cell (2) · Cholangiocarcinoma (2) · Colitis (2) · Head and Neck Neoplasms (2) · Lung Neoplasms (2)
Neoplasms (28) · Neoplasms by Site (26) · Hematologic Diseases (14) · Hemic and Lymphatic Diseases (14) · Neoplasms by Histologic Type (10) · Skin Diseases (9) · Skin and Connective Tissue Diseases (9) · Digestive System Diseases (8) · Male Urogenital Diseases (8) · Urogenital Diseases (8) · Female Urogenital Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (7) · Lung Diseases (7) · Respiratory Tract Diseases (7) · Nervous System Diseases (6)
Magnetic Resonance Spectroscopy (9) · Specimen Handling (9) · Practice Guidelines as Topic (7) · Standard of Care (7) · Biopsy (3) · CTLA-4 Antigen (3) · Disulfides (3) · Fluorodeoxyglucose F18 (3) · Immunoglobulin G (3) · Ipilimumab (3) · Nivolumab (3) · atezolizumab (3) · cabozantinib (3) · pembrolizumab (3) · 130-nm albumin-bound paclitaxel (2)
M.D. Anderson Cancer Center (10) · National Cancer Institute (NCI) (8) · City of Hope Medical Center (3) · Fred Hutchinson Cancer Center (3) · Jonsson Comprehensive Cancer Center (2) · Mayo Clinic (2) · Roswell Park Cancer Institute (2) · Emory University (1) · Jennifer Woyach (1) · NRG Oncology (1) · OHSU Knight Cancer Institute (1) · Ohio State University Comprehensive Cancer Center (1) · Theodore Brasky PhD (1)
United States (35) · Canada (2) · Australia (1) · Puerto Rico (1)
Jeremie Calais (2) · Yinghong Wang (2) · Ali J. Zarrabi, MD (1) · Alpana Waghmare (1) · Amanda Olson (1) · Ammar Chaudhry (1) · Andrea B Apolo (1) · Apostolia M Tsimberidou (1) · Aung Naing (1) · David Maloney (1) · Faye M Johnson, MD (1) · Franklin C Wong (1) · Hussein A Tawbi (1) · Igor Puzanov (1) · James Welsh (1)
PMID 31996395, PMID 32827353, PMID 32915679, PMID 33051340, PMID 33096027, PMID 33357452, PMID 34749885, PMID 35031545, PMID 35470301, PMID 36873868, PMID 37010988, PMID 37555284, PMID 38954785, PMID 40139261, PMID 40721981, PMID 41646361, PMID 42501677
P30CA033572 (3), UM1CA186691 (3), UM1CA186688 (2), UM1CA186716 (2), UM1CA186717 (2), ZIABC011078 (2), P30CA016056 (1), P30CA138292 (1), R01CA114536 (1), R01CA283547 (1), U01CA062490 (1), U01CA132194 (1), U10CA180868 (1), UM1CA186686 (1), UM1CA186689 (1)