22 active not recruiting, 8 recruiting, 7 completed, 5 terminated. 49 Phase 2, 11 Phase 1.
Follow Malignant Solid Neoplasm: new trials by email Literature Review of Malignant Solid Neoplasm trials Research Report on Malignant Solid Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cannabis Gummy for the Improvement of Sleep and Quality of Life in Patients With Cancer, Pillow Trial Actigraphy, Best Practice, Biospecimen Collection - Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm | Phase 1 / Phase 2 | Not yet recruiting | Theodore Brasky PhD | 50 | 2027-01-15 | 2026-10-14 |
| Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) for the Treatment of Patients With Progressing Metastatic Neuroendocrine Carcinomas Biospecimen Collection, Computed Tomography, Incomplete Freund''s Adjuvant - Digestive System Neuroendocrine Neoplasm, Lung Neuroendocrine Neoplasm | Phase 2 | Not yet recruiting | Roswell Park Cancer Institute | 60 | 2026-12-15 | 2026-10-20 |
| THC Versus THC/CBD Versus Placebo to Improve Sleep Quality for Patients With Solid Organ Cancer and Insomnia Biospecimen Collection, Placebo Administration, Single Agent Therapy - Insomnia, Malignant Solid Neoplasm | Phase 2 | Not yet recruiting | Mayo Clinic | 69 | 2026-10-01 | 2026-09-02 |
| Psilocybin With Psychotherapy for Improving Chronic Pain in Cancer Patients Requiring Opioids Biospecimen Collection, Functional Magnetic Resonance Imaging, Interview - Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm | Phase 2 | Not yet recruiting | Roswell Park Cancer Institute | 20 | 2026-09-15 | 2026-08-12 |
| The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas Cancer Therapeutic Procedure, Questionnaire Administration - Amyloidosis, Basal Cell Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 27 | 2025-12-18 | 2026-09-30 |
| Fucoidan for Preventing Chemotherapy-Related Fatigue in Patients With Gastrointestinal, Gynecological, Breast, or Lung Cancer Biospecimen Collection, Oligo-fucoidan, Placebo Administration - Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm | Phase 2 | Recruiting | Mayo Clinic | 34 | 2025-03-06 | 2026-10-16 |
| A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study Discussion, Goal Setting, Interview - Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm | Phase 2 | Recruiting | Children's Oncology Group | 190 | 2024-10-15 | 2026-02-27 |
| Interstitial Photodynamic Therapy Following Palliative Radiotherapy in Treating Patients With Inoperable Malignant Central Airway Obstruction Biospecimen Collection, Computed Tomography, Endobronchial Ultrasound Bronchoscopy - Malignant Solid Neoplasm | Phase 1 / Phase 2 | Recruiting | Roswell Park Cancer Institute | 42 | 2024-10-01 | 2026-04-06 |
| Cryocompression With or Without Cilostazol for the Prevention of Paclitaxel-induced Neuropathy in Patients With Gynecological Cancers Best Practice, Cilostazol, Cryocompression Therapy - Cervical Carcinoma, Fallopian Tube Carcinoma | Phase 2 | Recruiting | Emory University | 70 | 2024-08-01 | 2026-08-27 |
| Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial) Biopsy Procedure, Biospecimen Collection, Computed Tomography - Malignant Female Reproductive System Neoplasm, Malignant Solid Neoplasm | Phase 2 | Recruiting | National Cancer Institute (NCI) | 70 | 2024-05-07 | 2026-10-30 |
| Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program Home Health Encounter, Nivolumab, Patient Monitoring - Advanced Esophageal Squamous Cell Carcinoma, Advanced Renal Cell Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 50 | 2024-04-30 | 2026-10-02 |
| Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial Binimetinib, Biopsy Procedure, Biospecimen Collection - Exocrine Pancreas Carcinoma, Malignant Solid Neoplasm | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 199 | 2023-12-13 | 2026-08-21 |
| Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters Acetaminophen, Biospecimen Collection, Broccoli Sprout/Broccoli Seed Extract Supplement - Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 72 | 2023-12-04 | 2026-09-23 |
| Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma Biospecimen Collection, Computed Tomography, Positron Emission Tomography - Lung Non-Small Cell Carcinoma, Malignant Solid Neoplasm | Phase 2 | Recruiting | City of Hope Medical Center | 32 | 2023-11-29 | 2026-08-31 |
| Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers Biospecimen Collection, Informational Intervention, Quality-of-Life Assessment - Localized Prostate Carcinoma, Locally Advanced Cervical Carcinoma | Phase 2 | Active not recruiting | City of Hope Medical Center | 49 | 2023-03-23 | 2026-10-20 |
| Itacitinib for the Treatment Steroid Refractory Immune Related Adverse Events Arising From Immune Checkpoint Inhibitors Itacitinib, Corticosteroid, Endoscopic Procedure - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Phase 2 | Withdrawn | Douglas Johnson | 2023-03-03 | 2026-04-27 | |
| Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors Atezolizumab, Biospecimen Collection, Computed Tomography - Atypical Teratoid/Rhabdoid Tumor, Epithelioid Sarcoma | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 86 | 2022-11-17 | 2026-07-14 |
| Testing the Combination of Anti-Cancer Drugs Talazoparib and Temozolomide in Patients With Advanced Stage Rare Cancers, RARE 2 Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Malignant Solid Neoplasm | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 14 | 2022-07-11 | 2026-10-14 |
| Topical Cannabidiol for the Treatment of Chemotherapy-Induced Peripheral Neuropathy Cannabidiol, Placebo Administration, Quality-of-Life Assessment - Chemotherapy-Induced Peripheral Neuropathy, Malignant Solid Neoplasm | Phase 2 | Completed | Mayo Clinic | 40 | 2022-06-09 | 2026-01-16 |
| PEA for the Relief of Chemotherapy-Induced Peripheral Neuropathy Palmidrol, Placebo Administration, Quality-of-Life Assessment - Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphoid Cell Neoplasm | Phase 2 | Active not recruiting | Academic and Community Cancer Research United | 88 | 2022-05-16 | 2025-09-22 |
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Hematologic Neoplasms (13) · Melanoma (7) · Carcinoma, Non-Small-Cell Lung (5) · Ovarian Neoplasms (5) · Colorectal Neoplasms (4) · Sarcoma (4) · Carcinoma, Renal Cell (3) · Carcinoma, Transitional Cell (3) · Lung Neoplasms (3) · Osteosarcoma (3) · Pancreatic Neoplasms (3) · Prostatic Neoplasms (3) · Rhabdoid Tumor (3) · Breast Neoplasms (2) · Carcinoma, Basal Cell (2)
Neoplasms (36) · Neoplasms by Site (33) · Hemic and Lymphatic Diseases (17) · Hematologic Diseases (15) · Neoplasms by Histologic Type (15) · Urogenital Diseases (14) · Urogenital Neoplasms (13) · Female Urogenital Diseases (12) · Female Urogenital Diseases and Pregnancy Complications (12) · Respiratory Tract Diseases (12) · Lung Diseases (11) · Digestive System Diseases (10) · Neoplasms, Germ Cell and Embryonal (10) · Neoplasms, Glandular and Epithelial (10) · Digestive System Neoplasms (9)
Specimen Handling (20) · Magnetic Resonance Spectroscopy (10) · Biopsy (9) · Nivolumab (4) · Practice Guidelines as Topic (4) · Standard of Care (4) · X-Rays (4) · CTLA-4 Antigen (3) · Disulfides (3) · Immunoglobulin G (3) · Ipilimumab (3) · Cyclophosphamide (2) · Drug Therapy (2) · Infliximab (2) · Interviews as Topic (2)
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United States (47) · Puerto Rico (6) · Australia (3) · Canada (3) · Guam (1) · New Zealand (1) · South Korea (1)
Amir A Jazaeri (2) · A P Chen (1) · Alain C Mita (1) · Amanda Olson (1) · Arya Amini (1) · Aung Naing (1) · Betul Oran (1) · Christine A Pratilas (1) · Daniel Lin, MD (1) · Douglas Johnson, MD (1) · Faye M Johnson, MD (1) · Geoffrey I Shapiro (1) · Haider S Mahdi (1) · Igor Puzanov (1) · Issam I Raad (1)
PMID 27716152, PMID 31401903, PMID 31924662, PMID 31969335, PMID 31996395, PMID 33051340, PMID 33096027, PMID 33362722, PMID 33568350, PMID 33882143, PMID 34380663, PMID 34486544, PMID 34716198, PMID 34749885, PMID 35537412, PMID 37328287, PMID 37970718, PMID 38243705, PMID 38309721, PMID 38358334, PMID 38433347, PMID 39016024, PMID 39067873, PMID 39343510, PMID 39417692, PMID 39456544, PMID 39583952, PMID 39856213, PMID 40139261, PMID 40402690, PMID 40588371, PMID 40721981, PMID 41646361, PMID 41672597, PMID 41892875, PMID 41995270, PMID 42499790, PMID 42853672
P30CA033572 (3), U10CA180820 (3), U10CA180886 (2), UG1CA189955 (2), P30CA015083 (1), P30CA016056 (1), P30CA023074 (1), P30CA138292 (1), R01CA196854 (1), R01CA274450 (1), R01CA283547 (1), R01HL151367 (1), U01CA062490 (1), U01CA132194 (1), U10CA180821 (1)