92 completed, 17 terminated, 16 active not recruiting, 12 recruiting. 74 Phase 1, 63 Phase 2, 17 Not applicable, 5 Early Phase 1, 2 Phase 3.
Follow Malignant Glioma: new trials by email Literature Review of Malignant Glioma trials Research Report on Malignant Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FPS-ZM1 With or Without Dexamethasone for Controlling Post Operative Cerebral Edema in Patients With Glioblastoma Biospecimen Collection, Computed Tomography, Dexamethasone - Glioblastoma, Malignant Glioma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 24 | 2027-02-17 | 2026-08-27 |
| Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas Biospecimen Collection, Eflornithine, Lumbar Puncture - Anaplastic Oligodendroglioma, Astrocytoma, IDH-Mutant, Grade 3 | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 33 | 2026-06-23 | 2026-06-24 |
| Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma Dual-target CAR-NK cells, Cyclophosphamide, Intracranial catheter/reservoir for locoregional delivery - Malignant Glioma, High-Grade Gliomas | Phase 1 | Recruiting | Beijing Biotech | 36 | 2026-03-02 | 2026-04-24 |
| Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma Dual-target CAR-NK cells, Cyclophosphamide, Fludarabine - Glioblastoma, High-grade Glioma | Phase 1 | Recruiting | Beijing Biotech | 36 | 2026-02-02 | 2026-03-18 |
| T2 Star Magnetic Resonance Imaging and Biomarker Blood Testing to Predict the Change and Progress of Malignant Gliomas T2 (Observed)-Weighted Imaging, Biospecimen Collection, Magnetic Resonance Imaging - Malignant Glioma | Not applicable | Recruiting | John M. Buatti | 15 | 2025-10-03 | 2026-03-03 |
| Dexamethasone and Azeliragon for Management of Post-Resection Cerebral Edema in Patients with Glioblastoma Azeliragon, Biospecimen Collection, Computed Tomography - Glioblastoma, Malignant Glioma | Phase 1 | Withdrawn | City of Hope Medical Center | 2024-11-15 | 2024-09-19 | |
| Fitness and Nutrition in Glioma Modified Atkins Diet, Fitness Program - Malignant Glioma | Not applicable | Active not recruiting | NYU Langone Health | 15 | 2024-10-01 | 2026-07-01 |
| Mapping of Electrical Properties in the Brain Non-Interventional Study - Malignant Glioma | Recruiting | Mayo Clinic | 120 | 2024-09-13 | 2026-02-03 | |
| Intratumoral Extracellular Metabolic Impact of DFMO and AMXT 1501 in Patients With Diffuse or High Grade Glioma Biospecimen Collection, Computed Tomography, Eflornithine - Diffuse Glioma, Malignant Glioma | Early Phase 1 | Recruiting | Mayo Clinic | 18 | 2023-10-01 | 2025-11-04 |
| Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial Radiation Therapy, Radiosurgery, Stereotactic Biopsy - Malignant Glioma | Phase 1 | Recruiting | Mayo Clinic | 28 | 2023-05-23 | 2026-09-30 |
| CARv3-TEAM-E T Cells in Glioblastoma CARv3-TEAM-E T cells - Glioblastoma, Malignant Glioma | Phase 1 | Recruiting | Marcela V. Maus, M.D.,Ph.D. | 21 | 2023-03-22 | 2026-07-14 |
| Safety Study of the Repeated Opening of the Blood-brain Barrier With the SonoCloud® Device to Treat Malignant Brain Tumors in Pediatric Patients SonoCloud® (9 transducers) - Malignant Brain Tumor, Malignant Glioma | Phase 1 | Recruiting | Assistance Publique - Hôpitaux de Paris | 24 | 2023-02-06 | 2026-05-06 |
| A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG) Biopsy Procedure, Magnetic Resonance Imaging, Radiation Therapy - Malignant Glioma | Phase 1 / Phase 2 | Suspended | National Cancer Institute (NCI) | 132 | 2022-05-31 | 2026-10-13 |
| Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma TMZ, ipilimumab 3mg/kg, Nivolumab - Glioblastoma, Gliosarcoma | Phase 2 | Completed | National Cancer Institute (NCI) | 47 | 2021-12-08 | 2026-04-17 |
| The PCSK9i Inhibitor Evolocumab - a Surgical Trial of Pharamcodynamics and Kinetics Evaluation Evolocumab - Malignant Glioma, Glioblastoma | Early Phase 1 | Completed | Duke University | 32 | 2021-10-08 | 2024-06-25 |
| Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma Biospecimen Collection, Diagnostic Imaging, Magnetic Resonance Imaging - Glioma, Malignant Glioma | Early Phase 1 | Active not recruiting | Jonsson Comprehensive Cancer Center | 36 | 2021-09-01 | 2026-10-20 |
| Personalized Vaccine for Patients With Recurrent Malignant Glioma personalized vaccine - Malignant Glioma, Recurrent Glioma | Phase 1 | Unknown | Xuanwu Hospital, Beijing | 10 | 2021-07-15 | 2021-06-29 |
| Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer Etoposide, Fludarabine Phosphate, Hematopoietic Cell Transplantation - Anaplastic Ependymoma, Atypical Teratoid/Rhabdoid Tumor | Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2021-01-14 | 2024-10-26 | |
| Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal Epilepsy Anticonvulsant Agent, Perampanel, Quality-of-Life Assessment - Intractable Epilepsy, Malignant Glioma | Phase 4 | Terminated | Mayo Clinic | 4 | 2020-12-04 | 2023-06-22 |
| Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults Nivolumab, Quality-of-Life Assessment, Questionnaire Administration - Glioblastoma, Malignant Glioma | Phase 1 | Active not recruiting | Sabine Mueller, MD, PhD | 9 | 2020-10-02 | 2026-06-15 |
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Glioma (156) · Glioblastoma (71) · Brain Neoplasms (39) · Astrocytoma (31) · Gliosarcoma (13) · Oligodendroglioma (13) · Ependymoma (10) · Medulloblastoma (10) · Central Nervous System Neoplasms (7) · Neoplasms (7) · Recurrence (7) · Rhabdoid Tumor (7) · Lymphoma, Follicular (6) · Lymphoma, Non-Hodgkin (5) · Sarcoma (5)
Neoplasms by Histologic Type (156) · Neoplasms, Glandular and Epithelial (156) · Neoplasms, Nerve Tissue (156) · Neoplasms, Neuroepithelial (156) · Neuroectodermal Tumors (156) · Neoplasms, Germ Cell and Embryonal (154) · Neoplasms (149) · Neoplasms by Site (48) · Nervous System Diseases (48) · Nervous System Neoplasms (45) · Astrocytoma (44) · Brain Diseases (42) · Central Nervous System Diseases (42) · Central Nervous System Neoplasms (39) · Hemic and Lymphatic Diseases (13)
Magnetic Resonance Spectroscopy (17) · Temozolomide (17) · Bevacizumab (15) · Radiotherapy (14) · Specimen Handling (10) · Surgical Procedures, Operative (7) · Nivolumab (6) · Radiation (5) · fluorodopa F 18 (5) · Biopsy (4) · Cyclophosphamide (4) · Granulocyte-Macrophage Colony-Stimulating Factor (4) · IL13-PE38 (4) · Irinotecan (4) · Radiosurgery (4)
National Cancer Institute (NCI) (13) · Duke University (11) · Mayo Clinic (10) · M.D. Anderson Cancer Center (5) · INSYS Therapeutics Inc (4) · University of Florida (4) · Candel Therapeutics, Inc. (3) · Children's Oncology Group (3) · City of Hope Medical Center (3) · Darell Bigner (3) · H. Lee Moffitt Cancer Center and Research Institute (3) · Istari Oncology, Inc. (3) · Memorial Sloan Kettering Cancer Center (3) · TransMolecular (3) · AHS Cancer Control Alberta (2)
United States (128) · Canada (10) · China (6) · Puerto Rico (6) · France (5) · Japan (5) · Australia (4) · Belgium (2) · Denmark (2) · Germany (2) · Netherlands (2) · New Zealand (2) · Spain (2) · Finland (1) · Israel (1)
Annick Desjardins, MD, FRCPC (6) · Daniel Landi, MD (4) · Katherine B Peters, MD, PhD (3) · Katherine Peters, MD, PhD (3) · Antonio Omuro, MD (2) · Duane Mitchell, MD, PhD (2) · E. Antonio Chiocca, MD, PhD (2) · Hideho Okada, MD, PhD (2) · Jana L Portnow (2) · Jeffrey Raizer, MD (2) · Jing Wu, M.D. (2) · John Fiveash, MD (2) · Julia Glade-Bender (2) · Macarena De La Fuente, MD (2) · Nadia N. Laack, M.D. (2)
PMID 31401903, PMID 37072349, PMID 15809479, PMID 16648043, PMID 16877732, PMID 21844505, PMID 21984064, PMID 21986722, PMID 22037923, PMID 22780919, PMID 23545055, PMID 24327518, PMID 24572293, PMID 25572329, PMID 25586468, PMID 26843484, PMID 27424289, PMID 28013405, PMID 28053024, PMID 28286803, PMID 28672195, PMID 28720549, PMID 28870792, PMID 29133513, PMID 29383130, PMID 29652233, PMID 29846250, PMID 29943666, PMID 30232146, PMID 30405781, PMID 30883662, PMID 30975030, PMID 31101621, PMID 31533931, PMID 31831767, PMID 31882719, PMID 31894292, PMID 32436060, PMID 33486637, PMID 33500356, PMID 33591402, PMID 33771703, PMID 33838625, PMID 33859944, PMID 34171339, PMID 34331515, PMID 34609773, PMID 34642366, PMID 34882581, PMID 35001215
U10CA180886 (7), P30CA033572 (3), UM1CA081457 (3), 2009 (2), U19CA264512 (2), 2017 (1), P30CA012197 (1), P30CA016059 (1), P30CA016672 (1), P30CA060553 (1), P30CA124435 (1), P50CA108961 (1), R01CA137488 (1), R01CA175517 (1), R01CA178200 (1)