6 completed. 6 Phase 2, 4 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 6 |
| Phase 1 | 4 | Completed 4 |
| Phase 3 | 1 | Completed 1 |
Follow Major Depressive Episode: new trials by email Literature Review of Major Depressive Episode trials Research Report on Major Depressive Episode
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Ultrasonic Brain Stimulation for Depression (R61) LTFUS to SCC, LTFUS to ALIC - Major Depressive Episode, Depression - Major Depressive Disorder | Phase 1 / Phase 2 | Completed | Brian Mickey | 39 | 2025-03-10 | 2026-11-03 |
| Personalized Ultrasonic Brain Stimulation for Depression Diadem prototype - Major Depressive Episode | Phase 1 / Phase 2 | Completed | University of Utah | 22 | 2022-07-15 | 2026-09-09 |
| A Study to Evaluate SAGE-217 in Participants With Bipolar I/II Disorder With a Current Major Depressive Episode SAGE-217, Placebo - Bipolar Disorder I, Bipolar Disorder II | Phase 2 | Completed | Biogen | 35 | 2018-08-23 | 2023-12-13 |
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) electroconvulsive therapy (ECT), Ketamine - Treatment Resistant Depression, Electroconvulsive Therapy | Phase 2 / Phase 3 | Completed | Bo Hu | 403 | 2017-04-07 | 2023-09-28 |
| Ketamine for Suicidality in Bipolar Depression Ketamine, Midazolam - Bipolar Disorder, Major Depressive Episode | Phase 1 / Phase 2 | Completed | New York State Psychiatric Institute | 16 | 2013-09-01 | 2020-03-11 |
| Study Comparing Magnetic Seizure Therapy (MST) to Electroconvulsive Therapy (ECT) for Depression in Older Adults MagVenture MagPro MST, RUL ECT - Depression, Major Depressive Episode | Phase 1 / Phase 2 | Completed | New York State Psychiatric Institute | 18 | 2012-08-01 | 2020-09-03 |
Bipolar Disorder (3) · Depression (3) · Depressive Disorder (1) · Depressive Disorder, Major (1) · Depressive Disorder, Treatment-Resistant (1) · Mental Disorders (1) · Suicidal Ideation (1) · Suicide (1)
Mood Disorders (4) · Behavior (3) · Behavioral Symptoms (3) · Bipolar and Related Disorders (3) · Mental Disorders (3) · Self-Injurious Behavior (1)
Ketamine (2) · Electroconvulsive Therapy (1) · Midazolam (1) · zuranolone (1)
New York State Psychiatric Institute (2) · Biogen (1) · Bo Hu (1) · Brian Mickey (1) · University of Utah (1)
United States (6)
Amit Anand, MD (1) · Brian J Mickey (1) · Brian J Mickey, MD, PhD (1) · Michael F Grunebaum, M.D. (1) · Stefan B Rowny, MD, MFA (1)
PMID 30572160, PMID 34131914, PMID 37224232, PMID 37891643, PMID 40900112
R61MH134943 (1)