9 completed, 8 active not recruiting, 5 recruiting, 3 terminated. 14 Phase 2, 4 Phase 1, 3 Not applicable, 3 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Positron Emission Tomography/Computed Tomography (PET/CT) Imaging in Patients Diagnosed With a Glioma Minocycline 200mg/day, [18F]FETrp PET/CT - Low Grade Glioma, Glioblastoma | Phase 2 | Not yet recruiting | Barbara Ann Karmanos Cancer Institute | 61 | 2026-09-01 | 2026-07-30 |
| MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas Trametinib and Nivolumab, Dabrafenib, trametinib, nivolumab - Low Grade Glioma, High Grade Glioma | Phase 1 / Phase 2 | Recruiting | Ann & Robert H Lurie Children's Hospital of Chicago | 27 | 2025-04-01 | 2026-07-10 |
| Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial Biospecimen Collection, Computed Tomography, Dexamethasone - Low Grade Glioma, Malignant Brain Glioma | Phase 2 | Recruiting | Emory University | 200 | 2025-01-09 | 2026-02-10 |
| Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade Glioma model-guided optimization of treatment plan, standard treatment plan, no optimization - Low Grade Glioma | Phase 2 | Recruiting | University Hospital Heidelberg | 120 | 2023-11-11 | 2024-01-05 |
| A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors PF-07799544, PF-07799933 - Melanoma, Glioma | Phase 1 | Active not recruiting | Pfizer | 148 | 2022-11-30 | 2026-09-01 |
| Seizure Control as a New Metric in Assessing Efficacy of Tumor Treatment in Patients With Low Grade Glioma Survey Administration - Brain Neoplasm, Low Grade Glioma | Active not recruiting | M.D. Anderson Cancer Center | 100 | 2020-07-08 | 2026-10-07 | |
| A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma Biospecimen Collection, Carboplatin, Echocardiography Test - Low Grade Astrocytoma, Low Grade Glioma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 170 | 2020-01-31 | 2026-11-06 |
| A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma Carboplatin, Magnetic Resonance Imaging, Quality-of-Life Assessment - Low Grade Glioma, Neurofibromatosis Type 1 | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 165 | 2020-01-15 | 2026-08-13 |
| Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy HP 13C Pyruvate, 3T MRI scanner - Glioma, Gliomas | Phase 2 | Completed | National Cancer Institute (NCI) | 42 | 2019-10-16 | 2026-11-06 |
| BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas PARP Inhibitor BGB-290, Temozolomide (TMZ) - Glioblastoma, IDH1 Gene Mutation | Phase 1 | Active not recruiting | University of California, San Francisco | 78 | 2019-04-03 | 2026-03-13 |
| Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype Nivolumab - Glioma, Glioblastoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 62 | 2019-03-27 | 2026-10-20 |
| Fluoroethyltyrosine for Evaluation of Intracranial Neoplasms F-18 Fluoroethyltyrosine (FET), Positron Emission Tomography (PET) - Intracranial Neoplasm, Low Grade Glioma | Phase 2 | Completed | Thomas Hope | 143 | 2018-10-29 | 2026-03-11 |
| Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial) Tazemetostat - Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Hodgkin Lymphoma | Phase 2 | Completed | National Cancer Institute (NCI) | 20 | 2017-11-13 | 2026-04-13 |
| Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial) Olaparib - Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma | Phase 2 | Completed | National Cancer Institute (NCI) | 6 | 2017-09-14 | 2024-12-11 |
| Mind-Body Intervention in Glioma Couples Mind-Body Intervention Procedure, Quality-of-Life Assessment, Questionnaire Administration - Glioblastoma, Low Grade Glioma | Not applicable | Active not recruiting | M.D. Anderson Cancer Center | 74 | 2017-08-06 | 2026-08-12 |
| Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG) Vinblastine, Bevacizumab - Low Grade Glioma | Phase 2 | Unknown | The Hospital for Sick Children | 109 | 2016-08-01 | 2024-01-31 |
| ROCOCO - Low Grade Glioma - Planning Study Low Grade Glioma | Completed | Maastricht Radiation Oncology | 25 | 2015-05-01 | 2017-03-28 | |
| A Study Comparing Two Carboplatin Containing Regimens for Children and Young Adults With Previously Untreated Low Grade Glioma Carboplatin and Vincristine, Carboplatin - Low Grade Glioma | Phase 3 | Completed | Alicia Lenzen | 95 | 2015-03-01 | 2026-09-02 |
| A Vaccine Trial for Low Grade Gliomas Experimental: HLA-A2 Restricted Glioma Antigen-Peptides with Poly-ICLC - Low Grade Glioma | Phase 2 | Recruiting | James Felker | 25 | 2015-01-01 | 2026-01-07 |
| Everolimus With and Without Temozolomide in Adult Low Grade Glioma Everolimus, Temozolomide - Low Grade Glioma, World Health Organization (WHO) Grade II Astrocytomas | Phase 2 | Terminated | University of California, San Francisco | 27 | 2014-03-19 | 2022-12-29 |
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Glioma (11) · Brain Neoplasms (8) · Glioblastoma (6) · Astrocytoma (4) · Ependymoma (3) · Central Nervous System Neoplasms (2) · Hepatoblastoma (2) · Histiocytosis, Langerhans-Cell (2) · Lymphoma, Non-Hodgkin (2) · Medulloblastoma (2) · Neuroblastoma (2) · Neuroectodermal Tumors, Primitive, Peripheral (2) · Neurofibromatosis 1 (2) · Oligodendroglioma (2) · Osteosarcoma (2)
Neoplasms (18) · Neoplasms by Histologic Type (18) · Neoplasms, Nerve Tissue (18) · Neoplasms, Germ Cell and Embryonal (16) · Neoplasms, Glandular and Epithelial (16) · Neoplasms, Neuroepithelial (16) · Neuroectodermal Tumors (16) · Nervous System Diseases (12) · Neoplasms by Site (10) · Nervous System Neoplasms (10) · Brain Diseases (8) · Central Nervous System Diseases (8) · Central Nervous System Neoplasms (8) · Astrocytoma (5) · Glioma (5)
Magnetic Resonance Spectroscopy (4) · Carboplatin (3) · Specimen Handling (3) · Vincristine (3) · Nivolumab (2) · Temozolomide (2) · (18F)fluoroethyltyrosine (1) · AZD 6244 (1) · Bevacizumab (1) · Calcium Dobesilate (1) · Dexamethasone (1) · Everolimus (1) · Mind-Body Therapies (1) · Minocycline (1) · O-(2-fluoroethyl)tyrosine (1)
National Cancer Institute (NCI) (8) · University of California, San Francisco (3) · M.D. Anderson Cancer Center (2) · Massachusetts General Hospital (2) · Alicia Lenzen (1) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Barbara Ann Karmanos Cancer Institute (1) · Emory University (1) · James Felker (1) · Maastricht Radiation Oncology (1) · Pfizer (1) · The Hospital for Sick Children (1) · Thomas Hope (1) · Turku University Hospital (1) · University Hospital Heidelberg (1)
United States (23) · Canada (4) · Puerto Rico (4) · Australia (2) · Germany (2) · Brazil (1) · China (1) · Finland (1) · France (1) · Israel (1) · Japan (1) · Netherlands (1) · New Zealand (1)
Jason R Fangusaro (2) · Jing Wu, M.D. (2) · Alicia Lenzen, MD (1) · Ashley Aaroe, MD (1) · Ashley Plant-Fox, MD (1) · Csaba Juhasz, M.D.,Ph.D. (1) · Eric Bouffet, MD (1) · Heikki R Minn, Professor (1) · Helen A Shih, MD (1) · James Felker, MD (1) · Jennifer Clarke, MD, MPH (1) · Julia Glade-Bender (1) · Kathrin Milbury (1) · Kimberly Hoang, MD (1) · Michael Prados, MD (1)
PMID 33395032, PMID 30118397, PMID 31151904, PMID 31401903, PMID 32597469, PMID 38815151, PMID 39393467
U10CA180886 (4), P30CA138292 (1), R01CA187219 (1), U01CA081457 (1), UM1CA081457 (1)