23 recruiting, 6 completed, 3 active not recruiting. 14 Not applicable, 8 Phase 2, 3 Early Phase 1, 3 Phase 1, 1 Phase 4.
Follow Localized Prostate Carcinoma: new trials by email Literature Review of Localized Prostate Carcinoma trials Research Report on Localized Prostate Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Effects of Exercise on Colorectal Cancer Development After Treatment With Pelvic Radiation Therapy for Prostate Cancer Aerobic Exercise, Biopsy Procedure, Biospecimen Collection - Colon Polyp, Colorectal Carcinoma | Not applicable | Recruiting | City of Hope Medical Center | 30 | 2026-12-16 | 2026-08-28 |
| MRI-based Focal Intraprostatic Simultaneous Integrated Boost (SIB) Intensification With De-escalated Adaptive-risk SBRT for Patients With Low to Intermediate Risk Prostate Cancer Microboost SBRT, Whole gland de-escalation 30 Gy, Whole gland de-escalation 35 Gy - Prostate Cancer, Localized Prostate Carcinoma | Phase 2 | Recruiting | Georgetown University | 58 | 2026-09-01 | 2026-08-20 |
| Study of PSMA-targeted Therapy and Androgen Receptor Suppression in Low-volume Metastatic ProstatE Cancer: SPARKLE Trial Abiraterone Acetate, Biospecimen Collection, Leuprolide Acetate - Recurrent Prostate Adenocarcinoma, Stage IVB Prostate Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 202 | 2026-08-04 | 2026-09-18 |
| Assessing Efficacy of Neoadjuvant ADT in Localized High-Risk Prostate Cancer Patients Utilizing 18F-Flotufolastat PSMA PET/CT Leuprolide, Degarelix, Relugolix - Prostate Cancer, Localized Prostate Carcinoma | Phase 2 | Recruiting | Baptist Health South Florida | 50 | 2026-07-29 | 2026-08-06 |
| Addressing Health Literacy With a Tailored Survivorship Care Plan Educational Intervention, Interview, Questionnaire Administration - Localized Prostate Carcinoma, Oligometastatic Prostate Carcinoma | Not applicable | Recruiting | Emory University | 150 | 2025-11-07 | 2026-09-30 |
| Feasibility and Effect of Wrapping Nerves With a Multi-Layer Perinatal Tissue Allograft During Prostatectomy Allografting, Survey Administration - Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Recruiting | Mayo Clinic | 45 | 2025-08-14 | 2026-09-11 |
| Comparison of 177Lu-PSMA-617 and 225Ac-PSMA-617 177 Lutetium Prostate-Specific Membrane Antigen 617, Actinium-225 Prostate-Specific Membrane Antigen 617, Non-investigational, Prostatectomy - Prostate Cancer, Prostate Cancer (Diagnosis) | Phase 1 | Recruiting | Thomas Hope | 45 | 2025-07-08 | 2026-08-28 |
| Testosterone Replacement Therapy for the Treatment of Low Testosterone in Hypogonadal Men With Localized Prostate Cancer on Active Surveillance Biopsy of Prostate, Biospecimen Collection, Magnetic Resonance Imaging - Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Phase 4 | Recruiting | Roswell Park Cancer Institute | 600 | 2025-01-15 | 2026-05-14 |
| Two-fraction HDR Monotherapy for Localized Prostate Cancer High Dose Rate Monotherapy - Prostate Adenocarcinoma, Localized Prostate Carcinoma | Not applicable | Recruiting | University of California, San Francisco | 17 | 2024-09-11 | 2026-09-17 |
| Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer Bilateral Pelvic Lymph Node Dissection, Biospecimen Collection, Bone Scan - Localized Prostate Carcinoma, Oligometastatic Prostate Carcinoma | Not applicable | Recruiting | Mayo Clinic | 50 | 2024-06-11 | 2026-04-06 |
| PSMA-Guided Ablation of the Prostate PSMA-1007 Positron Emission Tomography (PET) scan - Prostate Cancer, Localized Prostate Carcinoma | Phase 2 | Recruiting | University of Alberta | 138 | 2024-04-02 | 2026-06-03 |
| Two-Fraction Ultrahypofractionated Radiotherapy With Focal Boost for Intermediate Risk, Localized Prostate Cancer Ultrahypofractionated MRgRT in 2 fractions, Standard of care: MRgRT in 5 fractions - Prostate Cancer, Prostate Adenocarcinoma | Not applicable | Recruiting | UMC Utrecht | 160 | 2024-03-28 | 2024-07-24 |
| Online Adaptive Stereotactic Body Radiotherapy for Localized Prostate Cancer radiotherapy - Localized Prostate Carcinoma, Prostate Cancer (Adenocarcinoma) | Recruiting | University of Zurich | 75 | 2024-03-01 | 2026-07-06 | |
| Multi-omic Approach to Study HDR Brachytherapy for Favorable Risk and Low Tier Intermediate Risk Prostate Cancer High dose rate prostate brachytherapy - Localized Prostate Carcinoma | Recruiting | British Columbia Cancer Agency | 100 | 2024-02-01 | 2026-02-02 | |
| Extraperitoneal SINgle-port rObotic-assisted Radical Prostatectomy (RARP) Versus Transperitoneal Multi-port RARP in the Treatment Of Prostate Cancer (SINO-TOP) Single-port extraperitoneal robotic-assisted radical prostatectomy with Vattikuti Institute Prostatectomy（VIP） techniques, Multi-port transperitoneal robotic-assisted radical prostatectomy with bilateral intrafascial nerve-sparing techniques - Prostate Adenocarcinoma, Localized Prostate Carcinoma | Not applicable | Recruiting | Shanghai Changzheng Hospital | 480 | 2024-01-08 | 2026-07-23 |
| Focal Ablation With Focal Cryotherapy or HIFU for the Treatment of Men With Localized Prostate Cancer Cryosurgery, High-Intensity Focused Ultrasound Ablation, Survey Administration - Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Recruiting | University of California, Davis | 100 | 2023-11-09 | 2026-06-30 |
| 24 Gy in One Fraction Urethral-sparing "HDR Like" SBRT for Prostate Cancer prostate SBRT - Localized Prostate Carcinoma | Not applicable | Recruiting | IRCCS San Raffaele | 70 | 2023-11-08 | 2025-06-08 |
| Golf Recreational Exercise for Enhanced Survivorship in Prostate Cancer Survivors Biospecimen Collection, Discussion, Exercise Intervention - Localized Prostate Carcinoma, Locally Advanced Prostate Carcinoma | Not applicable | Recruiting | University of Southern California | 20 | 2023-09-01 | 2026-06-03 |
| Neoadjuvant ADT With TULSA in the Treatment of Intermediate Risk Prostate Cancer Degarelix, MRI-guided transurethral ultrasound ablation (TULSA) - Localized Prostate Carcinoma, Castration-Naive Prostate Cancer | Phase 1 | Active not recruiting | Turku University Hospital | 15 | 2023-07-18 | 2026-10-13 |
| Magnetic Resonance (MR) Imaging With Hyperpolarized Bicarbonate (13C) to Measure Tissue pH in Prostate Cancer Hyperpolarized Bicarbonate (13C), Magnetic Resonance imaging - Prostate Cancer, Localized Prostate Carcinoma | Early Phase 1 | Recruiting | Robert Flavell, MD, PhD | 10 | 2023-07-06 | 2026-10-13 |
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Prostatic Neoplasms (28) · Adenocarcinoma (1) · Colonic Polyps (1) · Colorectal Neoplasms (1) · Disease (1) · Erectile Dysfunction (1) · Lower Urinary Tract Symptoms (1) · Prostatic Hyperplasia (1) · Radiation Injuries (1) · Rectal Neoplasms (1)
Genital Diseases (28) · Genital Diseases, Male (28) · Genital Neoplasms, Male (28) · Male Urogenital Diseases (28) · Neoplasms (28) · Neoplasms by Site (28) · Prostatic Diseases (28) · Urogenital Diseases (28) · Urogenital Neoplasms (28) · Pathological Conditions, Signs and Symptoms (3) · Digestive System Diseases (2) · Digestive System Neoplasms (2) · Gastrointestinal Diseases (2) · Gastrointestinal Neoplasms (2) · Intestinal Diseases (2)
Specimen Handling (8) · Magnetic Resonance Spectroscopy (5) · Leuprolide (3) · Exercise Test (2) · Interviews as Topic (2) · Pluvicto (2) · Radiotherapy (2) · acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide (2) · luprolide acetate gel depot (2) · relugolix (2) · (225)Ac-PSMA-617 (1) · Abiraterone Acetate (1) · Biopsy (1) · Blood Specimen Collection (1) · Brachytherapy (1)
Mayo Clinic (5) · City of Hope Medical Center (3) · Emory University (2) · Baptist Health South Florida (1) · British Columbia Cancer Agency (1) · CHU de Quebec-Universite Laval (1) · Consorci Sanitari de Terrassa (1) · Fred Hutchinson Cancer Center (1) · Georgetown University (1) · IRCCS San Raffaele (1) · Ivan de Kouchkovsky, MD (1) · M.D. Anderson Cancer Center (1) · National Cancer Institute (NCI) (1) · Robert Flavell, MD, PhD (1) · Roswell Park Cancer Institute (1)
United States (23) · Canada (3) · China (1) · Finland (1) · Germany (1) · Italy (1) · Netherlands (1) · Switzerland (1)
Ram A. Pathak, MD (2) · Ahmed Aly (1) · Andre-Guy Martin (1) · Andrei Fodor, MD (1) · David Woodrum, MD, PhD (1) · Devaki Shilpa S Surasi (1) · George Salem, PhD (1) · Gerardo Colon-Otero, M.D. (1) · Gregory Idos (1) · I-Chow Hsu, MD (1) · Ivan de Kouchkovsky, MD (1) · Juan Chipollini (1) · Juanita M Crook, MD (1) · Lee Jones (1) · Marc Dall'Era (1)
PMID 11173128, PMID 11744442, PMID 12128107, PMID 17765406, PMID 18212313, PMID 18963537, PMID 19168203, PMID 19362783, PMID 19616743, PMID 19632069, PMID 20047800, PMID 21149658, PMID 21324610, PMID 21751904, PMID 21924511, PMID 22239226, PMID 22966812, PMID 23280183, PMID 23482774, PMID 23668632, PMID 24060175, PMID 24188255, PMID 25990489, PMID 26509844, PMID 2702835, PMID 27044935, PMID 27118583, PMID 27339115, PMID 27626136, PMID 27626365, PMID 28296582, PMID 30030111, PMID 30735235, PMID 30771408, PMID 30959121, PMID 31158102, PMID 31227373, PMID 31540791, PMID 33422612, PMID 33493500, PMID 33704378, PMID 3881377, PMID 40437508, PMID 40866948, PMID 41466435, PMID 41706486, PMID 7206090, PMID 8777417
P30CA033572 (2), P30CA138292 (2), P30CA014089 (1), P30CA023074 (1), P30CA093373 (1), P50CA097186 (1), R01CA211150 (1), R01CA214554 (1), R01CA238379 (1), R01CA300053 (1), R01EB017449 (1), U01EB026412 (1), UG1CA242596 (1)