9 completed, 5 not yet recruiting, 3 recruiting, 3 terminated. 12 Phase 2, 9 Phase 1, 3 Phase 3, 2 Not applicable.
Follow Leptomeningeal Metastases: new trials by email Literature Review of Leptomeningeal Metastases trials Research Report on Leptomeningeal Metastases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combined Intrathecal and Systemic Therapy With Trastuzumab Rezetecan for Leptomeningeal Metastases Intrathecal and systemic administration of Trastuzumab Rezetecan - Leptomeningeal Metastases, Solid Tumors | Phase 2 | Not yet recruiting | Jiuda Zhao | 28 | 2026-09-01 | 2026-09-22 |
| Phase 1 Study of WBRT or PCSI With REYOBIQ for Leptomeningeal Metastases 186RNL - Leptomeningeal Metastases | Phase 1 | Not yet recruiting | NYU Langone Health | 29 | 2026-07-01 | 2026-06-29 |
| Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer Sacituzumab Govitecan, Pemetrexed - Leptomeningeal Metastases | Phase 1 / Phase 2 | Recruiting | Guangzhou Medical University | 34 | 2026-01-01 | 2025-09-29 |
| High-Dose Firmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed in the Treatment of EGFR-Mutated Non-Small Cell Lung Cancer With Leptomeningeal Metastasis Combination therapy prospective cohort - Non Small Cell Lung Cancer, EGFR Mutation | Phase 2 | Not yet recruiting | Qiming Wang | 100 | 2025-05-15 | 2025-05-14 |
| Cerebrospinal Fluid Cytology-guided Intrathecal Chemo-holiday Therapy for EGFR-positive NSCLC Leptomeningeal Metastases pemetrexed, vometinib - Leptomeningeal Metastases | Phase 2 | Not yet recruiting | Zhejiang Cancer Hospital | 42 | 2025-04-01 | 2025-03-06 |
| Ivonescimab Combined With Chemotherapy for the Treatment of Leptomeningeal Metastases Failed to EGFR-TKIs Ivonescimab combined with chemotherapy - NSCLC, Chemotherapy | Not applicable | Not yet recruiting | Jiangsu Province Nanjing Brain Hospital | 36 | 2025-01-01 | 2025-01-09 |
| Evaluation of the Efficacy and Safety of Befotertinib Combined With Bevacizumab as First-Line Treatment for EGFR-Positive Non-Small Cell Lung Cancer With Brain Metastases: A Single-Arm, Open-Label, Prospective Phase II Clinical Study The treatment regimen is Befotertinib combined with Bevacizumab. - Non-small Cell Lung Cancer (NSCLC), EGFR Mutation-Positive Lung Cancer | Phase 2 | Active not recruiting | Li-kun Chen | 70 | 2024-09-04 | 2026-10-21 |
| ANG1005 in Leptomeningeal Disease From Breast Cancer ANG1005, Physician's Best Choice - Leptomeningeal Carcinomatosis, Leptomeningeal Metastases | Phase 3 | Unknown | Angiochem Inc | 150 | 2023-12-01 | 2023-04-24 |
| Dual-targeting VEGFR1 and PD-L1 CAR-T for Pleural, Peritoneal, or Leptomeningeal Metastases Dual-targeting VEGFR1/PD-L1 CAR-T cells - Malignant Peritoneal Effusion, Malignant Ascites | Phase 1 | Recruiting | Sichuan University | 40 | 2023-02-15 | 2026-08-13 |
| Intrathecal Pemetrexed for Leptomeningeal Metastasis Pemetrexed (1), Pemetrexed (2), Folic Acid - Leptomeningeal Metastases | Phase 1 / Phase 2 | Completed | The First Hospital of Jilin University | 34 | 2022-02-21 | 2025-05-04 |
| A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis Deferoxamine (DFO) - Leptomeningeal Metastases | Phase 1 | Recruiting | Memorial Sloan Kettering Cancer Center | 32 | 2021-12-22 | 2026-07-14 |
| Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors Involved-field Photon Radiation Therapy, Proton Craniospinal Irradiation (CSI), Neurocognitive Assessment - Leptomeningeal Metastases | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 102 | 2020-04-10 | 2026-02-27 |
| Avelumab With Radiotherapy in Patients With Leptomeningeal Disease Avelumab, Whole Brain Radiotherapy - Leptomeningeal Metastases, Leptomeningeal Disease | Phase 1 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 16 | 2019-06-10 | 2026-03-02 |
| BATs in Patients With Breast Cancer and Leptomeningeal Metastases HER2 BATs - Breast Cancer Female, Leptomeningeal Metastases | Phase 1 | Terminated | University of Virginia | 3 | 2019-02-26 | 2022-12-20 |
| 131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases 131I-omburtamab - Neuroblastoma, CNS Metastases | Phase 2 / Phase 3 | Terminated | Y-mAbs Therapeutics | 52 | 2018-12-11 | 2024-02-13 |
| Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases Proton craniospinal irradiation (CSI) - Leptomeningeal Metastases | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 24 | 2018-04-26 | 2022-12-23 |
| Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer Pemetrexed, Dexamethasone, Folic Acid - Leptomeningeal Metastases | Phase 1 | Completed | The First Hospital of Jilin University | 13 | 2017-03-01 | 2019-03-19 |
| Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases Tesevatinib - Non-Small Cell Lung Cancer, Leptomeningeal Metastases | Phase 2 | Completed | Kadmon Corporation, LLC | 36 | 2015-11-01 | 2022-03-16 |
| Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease pharmacological study, methotrexate - Leptomeningeal Metastases | Not applicable | Withdrawn | City of Hope Medical Center | 2012-09-01 | 2012-11-09 | |
| Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer Liposomal Cytarabine - Breast Cancer, Leptomeningeal Metastases | Phase 3 | Completed | Centre Oscar Lambret | 74 | 2011-08-30 | 2019-06-12 |
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Meningeal Carcinomatosis (23) · Brain Neoplasms (6) · Breast Neoplasms (5) · Carcinoma, Non-Small-Cell Lung (3) · Recurrence (3) · Meningeal Neoplasms (2) · Burkitt Lymphoma (1) · Central Nervous System Neoplasms (1) · Dendritic Cell Sarcoma, Interdigitating (1) · Lymphoma, Large B-Cell, Diffuse (1) · Medulloblastoma (1) · Neuroblastoma (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1)
Neoplasms (23) · Neoplasms by Site (23) · Nervous System Diseases (23) · Nervous System Neoplasms (23) · Central Nervous System Neoplasms (22) · Meningeal Neoplasms (21) · Brain Diseases (6) · Central Nervous System Diseases (6) · Breast Diseases (5) · Skin Diseases (5) · Skin and Connective Tissue Diseases (5) · Bronchial Neoplasms (3) · Carcinoma, Bronchogenic (3) · Disease Attributes (3) · Lung Diseases (3)
Pemetrexed (4) · Methotrexate (3) · Dexamethasone (2) · Folic Acid (2) · Vitamin B 12 (2) · merphos (2) · Bevacizumab (1) · Capecitabine (1) · Cytarabine (1) · Deferoxamine (1) · Drug Therapy (1) · Mental Status and Dementia Tests (1) · Temozolomide (1) · Topotecan (1) · XL647 (1)
Memorial Sloan Kettering Cancer Center (3) · The First Hospital of Jilin University (2) · Angiochem Inc (1) · Centre Oscar Lambret (1) · City of Hope Medical Center (1) · Dartmouth-Hitchcock Medical Center (1) · Guangzhou Medical University (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Jiangsu Province Nanjing Brain Hospital (1) · Jiuda Zhao (1) · Kadmon Corporation, LLC (1) · Li-kun Chen (1) · NYU Langone Health (1) · National Cancer Institute (NCI) (1) · Qiming Wang (1)
United States (10) · China (7) · Denmark (1) · France (1) · Japan (1) · Spain (1)
Zhenyu Pan (2) · Camilo Fadul, MD (1) · Daniel Higginson, MD (1) · Divya Yerramilli, MD (1) · Jessica Wilcox, MD (1) · JiuDa Zhao (1) · John Roemer, MD (1) · Jonathan Yang, MD, PhD (1) · Maciej Mrugala (1) · Mike Chen, MD (1) · Peter A Forsyth, MD (1) · Susan Blaney (1) · Thomas H. Davis, MD (1) · Yongsheng Wang, Prof. (1)
PMID 1447744, PMID 15117425, PMID 17315026, PMID 24991768, PMID 25601652, PMID 27243238, PMID 31544065, PMID 31637444, PMID 35802849, PMID 37879536, PMID 38464207, PMID 38642937, PMID 38820549, PMID 39073550, PMID 39083105, PMID 39661345, PMID 39661367, PMID 39661384, PMID 40699526, PMID 40888040, PMID 40906462, PMID 7595747, PMID 9533527
P30CA015704 (1), U10CA098543 (1)