Cardiometabolic Profiles of Pubertal Boys With Klinefelter Syndrome With or Without One Year of Exogenous Testosterone Treatment
| Registry | NCT02723305 |
|---|---|
| Status | Completed |
| Study type | Observational |
| Enrollment | 31 (Actual) |
| Sponsor | University of Colorado, Denver (Other) |
| Conditions | Klinefelter Syndrome, 47,XXY, Sex Chromosome Aneuploidy, XXY Syndrome |
| Interventions | No intervention (Other) |
| Dates | start 2016-05-01, primary completion 2017-12-01, completion 2017-12-01, first posted 2016-03-30, last updated 2022-03-08 |
| Locations | 1 site in United States |
Related Papers Related Patents Related Grants Related Experts
All trials for Klinefelter Syndrome All trials for 47,XXY All trials of No intervention
This study plans to learn more about how to measure the way the the body's energy system works in boys with Klinefelter syndrome, including the heart, lungs, muscles, and liver. This is important to know so that investigators understand how hormones and an extra X chromosome relate to diseases such as diabetes, extra weight gain, heart disease and liver diseases.
Klinefelter syndrome (KS) is the most common chromosomal abnormality in males and is associated with primary gonadal failure in adolescence and a high morbidity and mortality from cardiovascular-related diseases (CVD) in adulthood. Recent studies in children and adolescent boys with KS have found a high prevalence of CVD risk markers, however the underlying mechanisms have not been explored. Our central hypothesis is that pubertal boys with KS have relative testosterone deficiency resulting in abnormal energy metabolism that predisposes them to later CVD, and that exogenous testosterone will modify these abnormalities.
In this study, investigators will measure markers of cardiometabolic risk in pubertal boys with KS.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Testosterone Naive | Other: No intervention | Boys with Klinefelter syndrome age 12-17 who are Tanner 3, 4, or 5. No exogenous testosterone exposure in the past 5 years | |
| Testosterone exposed | Other: No intervention | Boys with Klinefelter syndrome age 12-17 who are Tanner 3, 4, or 5. +topical testosterone treatment for >1 year |
Sex: Male, ages: 12 Years to 17 Years
Inclusion Criteria: * Male, 47,XXY karyotype (non-mosaic) * Age 12-17 years * Tanner stage 3-5 pubic hair * T naïve group only: No exogenous androgen exposure within the past 5 years * T exposed group only: currently on topical testosterone, with duration of treatment between 1-2 years. Exclusion Criteria: * Cognitive, psychiatric, or physical impairment resulting in inability to tolerate the study procedures * MRI incompatible metal * Diagnosis of type 1 or type 2 diabetes * Hypertension greater than 140/90 mm/Hg at rest (would make exercise studies unsafe) * Weight > 300 lbs (limit for DEXA) * Testosterone treatment for <1 year or >2 years
| Facility | City | Country | Status |
|---|---|---|---|
| Children's Hospital Colorado | Aurora, Colorado | United States |
NIH grants: UL1TR001082