8 completed. 8 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Completed 8 |
| Phase 2 | 1 | Completed 1 |
Follow Intervertebral Disc Degeneration: new trials by email Literature Review of Intervertebral Disc Degeneration trials Research Report on Intervertebral Disc Degeneration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Posterior Cellular Bonegraft Options for Single Level Lumbar Spinal Fusion Use iliac bone graft, use bone morphogenetic protein, use bone derived allograft MSCs - Disc Degenerative Disease, Spine Fusion for Degenerative Spine Disease | Phase 2 / Phase 3 | Completed | Midwest Spine & Brain Institute | 119 | 2015-10-13 | 2025-10-08 |
| Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain Rexlemestrocel-L, Rexlemestrocel-L + HA Mixture, Placebo - Degenerative Disc Disease | Phase 3 | Completed | Mesoblast, Ltd. | 404 | 2015-03-06 | 2022-10-19 |
| XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD) XL TDR, Lumbar fusion surgery - Degenerative Disc Disease | Phase 3 | Completed | NuVasive | 246 | 2009-07-01 | 2015-07-30 |
| Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease HEALOS and Leopard Cage, Leopard Cage and Autograft - Degenerative Disc Disease | Phase 3 | Completed | Advanced Technologies and Regenerative Medicine, LLC (ATRM) | 138 | 2006-04-01 | 2011-03-03 |
| rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study rhBMP-2/CRM/CD HORIZON® Spinal System, Autograft/CD HORIZON® Spinal System - Degenerative Disc Disease | Phase 3 | Completed | Medtronic Spinal and Biologics | 463 | 2002-03-01 | 2023-05-10 |
| Performance of the Hedrocel(R) Cervical Fusion Device Anterior Cervical Discectomy and Fusion - Symptomatic Cervical Disc Disease | Phase 3 | Completed | Zimmer Biomet | 231 | 2001-12-01 | 2013-08-23 |
| Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion. Lumbar I/F with cage and pedicle screws - Degenerative Disc Disease | Phase 3 | Completed | DePuy Spine | 139 | 2000-12-01 | 2014-05-23 |
| CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease CHARITÉ Artificial Disc, Anterior Interbody Fusion with BAK Cage - Degenerative Disc Disease | Phase 3 | Completed | DePuy Spine | 304 | 2000-03-01 | 2014-05-23 |
Back Pain (1) · Bone Diseases (1) · Intervertebral Disc Displacement (1) · Intervertebral disc disease (1) · Low Back Pain (1) · Musculoskeletal Diseases (1) · Nervous System Diseases (1) · Neurologic Manifestations (1) · Pain (1) · Spinal Diseases (1)
Bone Diseases (7) · Musculoskeletal Diseases (7) · Spinal Diseases (7) · Pathological Conditions, Signs and Symptoms (2) · Hernia (1) · Pathological Conditions, Anatomical (1) · Signs and Symptoms (1)
Transplantation, Autologous (2) · Pedicle Screws (1) · Total Disc Replacement (1)
DePuy Spine (2) · Advanced Technologies and Regenerative Medicine, LLC (ATRM) (1) · Medtronic Spinal and Biologics (1) · Mesoblast, Ltd. (1) · Midwest Spine & Brain Institute (1) · NuVasive (1) · Zimmer Biomet (1)
United States (6) · Australia (1)
John Dimar, MD (1) · Kenneth Burkus, MD (1) · Roger Brown (1) · William D Smith, MD (1)