8 completed, 3 unknown, 2 terminated. 8 Not applicable, 3 Phase 4, 2 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 6, Unknown 2 |
| Phase 4 | 3 | Completed 2, Unknown 1 |
| Phase 2 | 2 | Terminated 2 |
| Phase 3 | 1 | Terminated 1 |
Follow Injection Site Irritation: new trials by email Literature Review of Injection Site Irritation trials Research Report on Injection Site Irritation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ondansetron as a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial Ondansetron, Lidocaine - Injection Site Irritation | Phase 2 | Terminated | Emory University | 6 | 2023-05-18 | 2026-04-24 |
| Topical Ice-therapy for Intravitreal Injections Ice-therapy, No Ice-therapy - Anesthesia; Hypothermia, Injection Site Irritation | Not applicable | Completed | University of Minnesota | 42 | 2022-04-01 | 2025-08-22 |
| Valsalva Manoeuvre and Intravenous Dexmedetomidine on Attenuating Pain During Propofol Injection in Upper GIT Endoscopy Valsalva Manoeuvre, Dexmedetomidine Injection [Precedex], normal Saline - Injection Site Irritation | Not applicable | Completed | Tanta University | 120 | 2022-02-19 | 2022-10-20 |
| Comparison of Subcutaneous Injection of Normal Saline and Bacteriostatic Saline Sodium Chloride 0.9% Inj, Bacteriostatic Sodium Chloride 0.9 % INJECTION VIAL (ML) - Injection Site Irritation, Injection Site Bruising | Phase 4 | Unknown | Jeffrey Alan Klein, MD | 32 | 2021-11-01 | 2021-11-05 |
| Sorrel 25R Injector - Sorrel Clinical Study Protocol Sorrel Wearable Injector - Injection Site, Injection Site Reaction | Not applicable | Unknown | Eitan Medical | 20 | 2021-08-23 | 2022-02-03 |
| Effects of Cyclooxygenase (COX) 1-2 Inhibitors on Prevention of Rocuronium Injection Pain Dexketoprofen (KETAVEL 50 mg/2 ml), Saline (Isotonic Saline Solution 0.9% ) - Injection Site Irritation | Not applicable | Completed | Ankara City Hospital Bilkent | 68 | 2020-11-01 | 2021-01-29 |
| Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain Lidocaine, Esmolol, Placebo - Injection Site Irritation, Pain | Phase 2 / Phase 3 | Terminated | Wake Forest University Health Sciences | 33 | 2020-09-09 | 2024-09-19 |
| Virtual Reality, Ice Application and Self-injection and Self-test Fair, Pain and State Anxiety motivational video production through virtual reality glasses, Ice Application - Injection Site Irritation, Fear of Pain | Not applicable | Completed | Inonu University | 159 | 2020-07-15 | 2022-12-06 |
| Warm Patch Decrease Propofol Injection Pain Warming patch, Cotton patch - Pain Syndrome, Propofol Infusion Syndrome | Not applicable | Completed | First People's Hospital of Chenzhou | 120 | 2020-03-20 | 2020-09-21 |
| A Warmer Temperature Decrease Propofol Injection Pain warmer temperature - Injection Site Irritation, Propofol Syndrome | Not applicable | Unknown | Xingui Dai | 120 | 2018-02-28 | 2018-02-05 |
| The Prevention of Pain Associated With Rocuronium Injection acetaminophen, Lidocaine, Placebo - Injection Site Irritation | Phase 4 | Completed | Suleyman Demirel University | 150 | 2014-05-01 | 2015-08-17 |
| Assessment of Pain on Propofol Injection. Propofol lidocaine through large vein, Propofol lidocaine through small vein - Injection Site Irritation | Not applicable | Completed | King Khalid University Hospital | 160 | 2013-05-01 | 2020-12-17 |
| Effect of Esmolol on Pain Due to Rocuronium Lidocaine, Esmolol, rocuronium - Injection Site Irritation | Phase 4 | Completed | Ankara Diskapi Training and Research Hospital | 90 | 2013-03-01 | 2019-10-04 |
Pain (3) · Propofol Infusion Syndrome (2) · Body Temperature Changes (1) · Hypothermia (1) · Iatrophobia (1) · Injection Site Reaction (1) · Somatoform Disorders (1)
Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (5) · Chemically-Induced Disorders (3) · Drug-Related Side Effects and Adverse Reactions (3) · Neurologic Manifestations (3) · Body Temperature Changes (1) · Extravasation of Diagnostic and Therapeutic Materials (1) · Mental Disorders (1) · Pathologic Processes (1)
Lidocaine (4) · Sodium Chloride (4) · Saline Solution (2) · esmolol (2) · Acetaminophen (1) · Dexmedetomidine (1) · Ice (1) · Injections (1) · Ondansetron (1) · Rocuronium (1) · Valsalva Maneuver (1) · dexketoprofen trometamol (1)
Ankara City Hospital Bilkent (1) · Ankara Diskapi Training and Research Hospital (1) · Eitan Medical (1) · Emory University (1) · First People's Hospital of Chenzhou (1) · Inonu University (1) · Jeffrey Alan Klein, MD (1) · King Khalid University Hospital (1) · Suleyman Demirel University (1) · Tanta University (1) · University of Minnesota (1) · Wake Forest University Health Sciences (1) · Xingui Dai (1)
United States (5) · Turkey (Türkiye) (3) · China (2) · Saudi Arabia (2)
Abdul Sattar Narejo, FCPS, FCAI (1) · Filiz Alkaya Solmaz (1) · Jade Moon, MD (1) · Marc C Torjman (1) · Michael Norton, MD (1) · Vipin Bansal, MD (1)