43 completed, 8 unknown, 7 terminated, 4 enrolling by invitation. 70 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 70 | Completed 43, Unknown 8, Terminated 7, Enrolling by invitation 4, Active not recruiting 3, Recruiting 3, Not yet recruiting 1, Withdrawn 1 |
Follow Hypersensitivity: new trials by email Literature Review of Hypersensitivity trials Research Report on Hypersensitivity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of HRS-3095 in Healthy Volunteers HRS-3095 - Chronic Spontaneous Urticaria | Early Phase 1 | Recruiting | Atridia Pty Ltd. | 36 | 2026-07-27 | 2026-08-07 |
| LYmph Node eXamination in Cat Allergen Immunotherapy Intradermal cat allergen challenge - Allergy | Early Phase 1 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 16 | 2026-04-10 | 2026-05-01 |
| An Open-label, Single-arm, Single-center Study to Evaluate the Diagnostic Efficacy of a Novel PET Probe, 68Ga-SFB6-ZN01, in Patients With Malignant Tumors 68Ga-SFB6-ZN01 - Neoplasms | Early Phase 1 | Not yet recruiting | Zhongnan Hospital | 98 | 2026-03-10 | 2026-03-03 |
| Comparison of Eohilia With Dupixent on Esophagus Diameter in Patients With Eosinophilic Esophagitis. Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT], budesonide oral suspension - Eosinophilic Esophagitis (EoE) | Early Phase 1 | Enrolling by invitation | Mayo Clinic | 60 | 2026-02-04 | 2026-05-04 |
| Thera-Clean® Microbubbles System in Patients With Skin Diseases TheraClean - Epidermolysis Bullosa, Ichthyosis | Early Phase 1 | Enrolling by invitation | Northwestern University | 20 | 2026-01-13 | 2026-02-03 |
| Effectiveness of 1st Rib Mobilization and Scalene Muscles Muscle Energy Technique Among Patients With Asthma First Rib Mobilization + Respiratory Physiotherapy, Scalene Muscle Energy Technique (MET) + Respiratory Physiotherapy - Asthma | Early Phase 1 | Active not recruiting | Superior University | 47 | 2025-03-04 | 2025-06-25 |
| Combination of Oral Supplement With Fatty Acids, Vitamin B6, Perilla, and Liquorice With Nasal Steroids for the Treatment of Allergic Rhinitis Oral fatty acid, Mometasone Furoate Nasal Spray (MFNS) - Allergic Rhinitis | Early Phase 1 | Completed | Isola Tiberina - Gemelli Isola Hospital, Rome, Italy | 400 | 2024-09-01 | 2025-06-12 |
| Timely Administration of IV Magnesium Sulfate in Patients With a Moderate Asthma Exacerbation Magnesium Sulfate within the first hour, No Magnesium sulfate within the first hour - Asthma in Children, Asthma Attack | Early Phase 1 | Recruiting | University of Oklahoma | 100 | 2023-11-30 | 2024-12-06 |
| Immunological Analysis of Lymph Node Tissue After Intralymphatic Immunotherapy: A Prospective Case Control Study Polvac Grass+Rye - Hypersensitivity, Hay Fever | Early Phase 1 | Completed | University of Zurich | 28 | 2023-11-23 | 2025-05-21 |
| Prospective Multicenter Observational Study and Promotion of the Application of Focused Ultrasound in Allergic Rhinitis High-intensity focused ultrasound (HIFU), intranasal corticosteroids, oral antihistamines, oral leukotriene receptor antagonists, and intranasal antihistamines - Allergic Rhinitis | Early Phase 1 | Unknown | Chongqing Medical University | 240 | 2023-08-01 | 2024-02-22 |
| Evaluation of the Efficacy and Safety of Methylprednisolone Combined With the JAK Inhibitors in the Treatment of Toxic Epidermal Necrolysis Abrocitinib, Tofacitinib - Toxic Epidermal Necrolysis | Early Phase 1 | Unknown | Peng Zhang | 30 | 2023-07-05 | 2023-11-28 |
| Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis Caffeine, Metoprolol, Midazolam - Atopic Dermatitis | Early Phase 1 | Completed | Amgen | 21 | 2023-06-03 | 2025-12-23 |
| Induced Pluripotent Stem Cell Derived Exosomes for the Treatment of Atopic Dermatitis GD-iExo-001, normal saline - Atopic Dermatitis | Early Phase 1 | Unknown | Peking Union Medical College Hospital | 20 | 2023-04-12 | 2023-08-01 |
| Impact Of Montelukast On Allergic Rhinitis And Its Inflammatory Makers Montelukast Oral Tablet - Allergic Rhinitis | Early Phase 1 | Unknown | Assiut University | 60 | 2022-10-01 | 2022-05-19 |
| IL-4 and Insulin Resistance for Treatment of Patients With Atopic Dermatitis Dupilumab, Photo therapy - Atopic Dermatitis | Early Phase 1 | Completed | Mayo Clinic | 7 | 2022-08-09 | 2024-02-26 |
| FAPI PET for Lung Fibrosis 68Ga-FAPi-46, Computed Tomography, Positron Emission Tomography - Interstitial Lung Disease, Idiopathic Interstitial Pneumonias | Early Phase 1 | Active not recruiting | University of California, Los Angeles | 30 | 2021-11-16 | 2026-08-20 |
| Cyclosporine Vs Steroids in DRESS Cyclosporine, Methylprednisolone and Prednisone - DRESS Syndrome, Drug-Induced Hypersensitivity Syndrome | Early Phase 1 | Enrolling by invitation | University of Southern California | 50 | 2021-09-27 | 2025-03-30 |
| Gastrointestinal STRING Test With Oral Immunotherapy Entero-tracker, omalizumab, dupliumab - Eosinophilic Disorder, Food Allergy | Early Phase 1 | Terminated | Stanford University | 13 | 2021-05-17 | 2024-09-19 |
| Characterizing Skin Microbiome Change in Atopic Dermatitis Crisaborole 2% Top Oint, Skin Microbiome Swabs - Atopic Dermatitis, Atopic Dermatitis Eczema | Early Phase 1 | Completed | University of California, Irvine | 20 | 2021-03-23 | 2024-02-02 |
| Effectiveness of a Mobile Health Intervention in Improving the Technique of Inhaled Medications Among Children With Asthma BreatheSuite - Asthma, Asthma in Children | Early Phase 1 | Completed | Memorial University of Newfoundland | 30 | 2021-01-01 | 2022-04-08 |
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Asthma (25) · Dermatitis, Atopic (12) · Pulmonary Disease, Chronic Obstructive (5) · Rhinitis, Allergic (5) · Chronic Urticaria (3) · Eosinophilic Esophagitis (3) · Food Hypersensitivity (3) · Milk Hypersensitivity (3) · Rhinitis, Allergic, Seasonal (3) · Lung Diseases, Interstitial (2) · Peanut Hypersensitivity (2) · Psoriasis (2) · Pulmonary Fibrosis (2) · Sarcoidosis (2)
Immune System Diseases (69) · Hypersensitivity, Immediate (57) · Respiratory Tract Diseases (35) · Respiratory Hypersensitivity (33) · Lung Diseases (27) · Bronchial Diseases (25) · Lung Diseases, Obstructive (24) · Skin and Connective Tissue Diseases (19) · Skin Diseases (18) · Dermatitis (15) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (14) · Genetic Diseases, Inborn (14) · Skin Diseases, Eczematous (13) · Skin Diseases, Genetic (12)
montelukast (6) · Budesonide (2) · Mannitol (2) · Omalizumab (2) · Saline Solution (2) · dupilumab (2) · Antigens, Dermatophagoides (1) · Caffeine (1) · Calcium Dobesilate (1) · Complement C1 Inhibitor Protein (1) · Cyclosporine (1) · Diphenhydramine (1) · Dobutamine (1) · Drugs, Generic (1) · Endoscopy, Digestive System (1)
National Institute of Allergy and Infectious Diseases (NIAID) (5) · Mayo Clinic (4) · Roxane Laboratories (4) · Hamilton Health Sciences Corporation (2) · Janssen Research & Development, LLC (2) · University of North Carolina, Chapel Hill (2) · University of Oklahoma (2) · Ace Cells Lab Limited (1) · Amgen (1) · Assaf-Harofeh Medical Center (1) · Assiut University (1) · Atridia Pty Ltd. (1) · Beijing Tongren Hospital (1) · Boston Children's Hospital (1) · Centre Hospitalier Universitaire de Besancon (1)
United States (42) · Canada (7) · China (5) · United Kingdom (3) · France (2) · Germany (2) · Netherlands (2) · Australia (1) · Belgium (1) · Denmark (1) · Israel (1) · Italy (1) · Malaysia (1) · Pakistan (1) · Romania (1)
Alan K Copa, PharmD (4) · Gail Gauvreau, PhD (2) · Hugh A. Sampson, MD (2) · Paul O'Byrne, MD (2) · Amin Javer, MD (1) · Amy Paller, MD (1) · Anna Nowak-Wegrzyn, MD (1) · Antonella Cianferoni, MD, PhD (1) · Barbara W. Carlson, RN, Ph.D. (1) · Carolyn Baloh, M.D. (1) · Christine A Sorkness, Pharm.D. (1) · Corinne Keet, MD, PhD (1) · Dale Umetsu, MD (1)
PMID 19001265, PMID 22318492, PMID 27978840, PMID 30846271, PMID 32679209, PMID 32883677, PMID 33099797, PMID 35584850, PMID 35691614, PMID 35762891, PMID 37945413, PMID 39362770, PMID 39837697
2023 (1), P01HL158507 (1), R01HL122424 (1), R01HL135235 (1), R61AT009989 (1), UL1TR001412 (1)