5 completed, 1 recruiting, 1 suspended, 1 terminated. 9 Phase 2, 4 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 5, Recruiting 1, Suspended 1, Terminated 1, Unknown 1 |
| Phase 1 | 4 | Completed 1, Recruiting 1, Suspended 1, Terminated 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
Follow Hyperhomocysteinemia: new trials by email Literature Review of Hyperhomocysteinemia trials Research Report on Hyperhomocysteinemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Acetaminophen and N-Acetylcysteine on Liver Metabolism on Homocystinuria Acetaminophen, N-acetylcysteine - CBS Deficiency | Phase 1 / Phase 2 | Suspended | Hospital de Clinicas de Porto Alegre | 10 | 2022-02-11 | 2021-06-30 |
| A Multiple Ascending Dose Study of ACN00177 (Pegtarviliase) in Subjects With CBS Deficiency Pegtarviliase IV, Pegtarviliase SC - Homocystinuria Due to Cystathionine Beta-Synthase Deficiency | Phase 1 / Phase 2 | Terminated | Aeglea Biotherapeutics | 13 | 2021-05-13 | 2023-07-27 |
| Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known as the COMPOSE Study) Pegtibatinase, Placebo - Homocystinuria | Phase 1 / Phase 2 | Recruiting | Travere Therapeutics, Inc. | 39 | 2019-01-22 | 2026-08-10 |
| Effectiveness of a Micronutrient Supplement to Lower Plasma Homocysteine MDEG2 Pilot Supplementation Trial novel micronutrient, existing micronutrient supplement, UNIMMAP - Micronutrient Deficiencies, Hyperhomocysteinemia | Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 298 | 2018-04-26 | 2019-01-22 |
| The Relationship Between HHcy and Contrast-induced Nephropathy in Hypertensive Patients After Coronary Artery Diagnosis and Treatment Enalapril Maleate Tablets(as the program-based antihypertension), Enalapril Maleate and Folic Acid tablets(as the program-based antihypertension), Placebo - Homocysteine, Coronary Disease | Phase 2 / Phase 3 | Completed | Fuling Central Hospital of Chongqing City | 4000 | 2015-11-01 | 2019-08-06 |
| Betaine METABOLISM OF PATIENTS With Homocystinuria Betaine - Homocystinuria | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 12 | 2015-07-01 | 2023-02-03 |
| Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine Amlodipine, amlodipine-FA tablet, low dose group, amlodipine-FA tablet ,high dose group - Essential Hypertension | Phase 2 / Phase 3 | Unknown | Shenzhen Ausa Pharmed Co.,Ltd | 756 | 2013-01-01 | 2013-05-08 |
| Oxidative Stress Markers In Inherited Homocystinuria And The Impact Of Taurine taurine - Homocystinuria | Phase 1 / Phase 2 | Completed | University of Colorado, Denver | 15 | 2010-01-01 | 2018-07-09 |
| Homocystinuria: Treatment With N-Acetylcysteine N-acetylcysteine - Homocystinuria | Phase 2 | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 5 | 2007-11-01 | 2009-02-18 |
Homocystinuria (6) · Hypertension (2) · Coronary Disease (1) · Essential Hypertension (1) · Kidney Diseases (1)
Amino Acid Metabolism, Inborn Errors (9) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (9) · Genetic Diseases, Inborn (9) · Metabolic Diseases (9) · Metabolism, Inborn Errors (9) · Nutritional and Metabolic Diseases (9) · Brain Diseases (6) · Brain Diseases, Metabolic (6) · Brain Diseases, Metabolic, Inborn (6) · Central Nervous System Diseases (6) · Connective Tissue Diseases (6) · Nervous System Diseases (6) · Skin and Connective Tissue Diseases (6) · Avitaminosis (3)
Acetylcysteine (2) · Acetaminophen (1) · Amlodipine (1) · Betaine (1) · Contraceptives, Oral (1) · Enalapril (1) · Population Groups (1) · Taurine (1)
Aeglea Biotherapeutics (1) · Assistance Publique - Hôpitaux de Paris (1) · Fuling Central Hospital of Chongqing City (1) · Hospital de Clinicas de Porto Alegre (1) · London School of Hygiene and Tropical Medicine (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Shenzhen Ausa Pharmed Co.,Ltd (1) · Travere Therapeutics, Inc. (1) · University of Colorado, Denver (1)
United States (3) · China (2) · France (2) · Australia (1) · Brazil (1) · Canada (1) · Qatar (1) · The Gambia (1) · United Kingdom (1)
Andrew Prentice, PhD (1) · Cortney Caudill (1) · Ida VD Schwartz, PhD (1) · Johan VanHove, MD PhD MBA (1) · Michael Imperiale, MD (1) · Yong Huo, MD (1)
PMID 19829124, PMID 21791335, PMID 31408467, PMID 36376887, PMID 40382700, PMID 42861767
2019 (1)