3 completed, 1 enrolling by invitation, 1 recruiting, 1 unknown. 6 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 3, Enrolling by invitation 1, Recruiting 1, Unknown 1 |
| Phase 2 | 2 | Completed 1, Unknown 1 |
Follow Hyperhomocysteinemia: new trials by email Literature Review of Hyperhomocysteinemia trials Research Report on Hyperhomocysteinemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥5 to ≤65 Years of Age With Classical Homocystinuria (HCU) (ENSEMBLE) Pegtibatinase - Homocystinuria | Phase 3 | Enrolling by invitation | Travere Therapeutics, Inc. | 100 | 2024-04-30 | 2026-05-28 |
| Pegtibatinase as a Treatment for Participants With Classical Homocystinuria (HCU) Receiving Standard of Care Treatment Pegtibatinase, Placebo - Homocystinuria | Phase 3 | Recruiting | Travere Therapeutics, Inc. | 70 | 2023-12-28 | 2026-10-08 |
| The Relationship Between HHcy and Contrast-induced Nephropathy in Hypertensive Patients After Coronary Artery Diagnosis and Treatment Enalapril Maleate Tablets(as the program-based antihypertension), Enalapril Maleate and Folic Acid tablets(as the program-based antihypertension), Placebo - Homocysteine, Coronary Disease | Phase 2 / Phase 3 | Completed | Fuling Central Hospital of Chongqing City | 4000 | 2015-11-01 | 2019-08-06 |
| Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine Amlodipine, amlodipine-FA tablet, low dose group, amlodipine-FA tablet ,high dose group - Essential Hypertension | Phase 2 / Phase 3 | Unknown | Shenzhen Ausa Pharmed Co.,Ltd | 756 | 2013-01-01 | 2013-05-08 |
| The Effects of 8-week Choline, Betaine, and Folic Acid Supplementation on Plasma Homocysteine Concentration During Guanidinoacetic Acid Loading in Young Healthy Volunteers TEST 1, TEST 2, TEST 3 - Hyperhomocysteinemia | Phase 3 | Completed | Center for Health Sciences, Serbia | 40 | 2011-05-01 | 2011-12-20 |
| Effects of Low-dose Complex B-vitamins on Homocysteine and Framingham Risk Score Among Chinese Elderly Low-dose complex B-vitamins - Hyperhomocysteinemia | Phase 3 | Completed | Peking University | 390 | 2007-07-01 | 2015-06-08 |
Homocystinuria (2) · Hypertension (2) · Coronary Disease (1) · Essential Hypertension (1) · Kidney Diseases (1)
Amino Acid Metabolism, Inborn Errors (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Genetic Diseases, Inborn (6) · Metabolic Diseases (6) · Metabolism, Inborn Errors (6) · Nutritional and Metabolic Diseases (6) · Avitaminosis (4) · Deficiency Diseases (4) · Malabsorption Syndromes (4) · Malnutrition (4) · Nutrition Disorders (4) · Vitamin B Deficiency (4) · Brain Diseases (2) · Brain Diseases, Metabolic (2) · Brain Diseases, Metabolic, Inborn (2)
Amlodipine (1) · Contraceptives, Oral (1) · Enalapril (1) · Population Groups (1)
Travere Therapeutics, Inc. (2) · Center for Health Sciences, Serbia (1) · Fuling Central Hospital of Chongqing City (1) · Peking University (1) · Shenzhen Ausa Pharmed Co.,Ltd (1)
China (3) · Australia (2) · Belgium (2) · France (2) · Germany (2) · Ireland (2) · Italy (2) · Poland (2) · Portugal (2) · Qatar (2) · Saudi Arabia (2) · Spain (2) · Turkey (Türkiye) (2) · United Kingdom (2) · United States (2)
Michael Imperiale, MD (2) · Jianmeng Liu, Prof. (1) · Sergej M Ostojic, MD, PhD (1) · Yong Huo, MD (1)