4 completed, 1 recruiting. 5 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Recruiting 1 |
| Phase 1 | 2 | Completed 2 |
Follow Hyper-IgM Immunodeficiency Syndrome: new trials by email Literature Review of Hyper-IgM Immunodeficiency Syndrome trials Research Report on Hyper-IgM Immunodeficiency Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD) Hematopoietic stem cell transplant (HSCT) - Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder | Phase 2 | Recruiting | Paul Szabolcs | 25 | 2026-05-04 | 2026-05-15 |
| Pilot Study Related to the Effect of Clopidogrel on Plasmatic Soluble CD40 Ligand During Systemic Lupus Erythematous Treatment by clopidogrel - Systemic Lupus Erythematous | Phase 1 / Phase 2 | Completed | University Hospital, Bordeaux | 18 | 2015-08-19 | 2026-05-14 |
| Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204) Hematopoietic Stem Cell Transplant - Hemophagocytic Lymphohistiocytosis, Chronic Active Epstein-Barr Virus Infection | Phase 2 | Completed | Medical College of Wisconsin | 47 | 2013-12-01 | 2022-12-08 |
| Immune Disorder HSCT Protocol Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan - Immune Deficiency Disorders, Severe Combined Immunodeficiency | Phase 2 | Completed | Washington University School of Medicine | 28 | 2013-04-29 | 2026-10-27 |
| Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells Hematopoietic stem cell transplantation - Sickle Cell Disease, Thalassemia | Phase 1 / Phase 2 | Completed | Children's Hospital Los Angeles | 25 | 2008-08-01 | 2016-06-23 |
Granulomatous Disease, Chronic (4) · Chediak-Higashi Syndrome (2) · Common Variable Immunodeficiency (2) · DiGeorge Syndrome (2) · Lymphohistiocytosis, Hemophagocytic (2) · Lymphoproliferative Disorders (2) · Severe Combined Immunodeficiency (2) · Wiskott-Aldrich Syndrome (2) · Anemia (1) · Anemia, Dyserythropoietic, Congenital (1) · Anemia, Sickle Cell (1) · Autoimmune Lymphoproliferative Syndrome (1) · Bruton type agammaglobulinemia (1) · Congenital amegakaryocytic thrombocytopenia (1)
Blood Protein Disorders (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Dysgammaglobulinemia (5) · Hematologic Diseases (5) · Hemic and Lymphatic Diseases (5) · Primary Immunodeficiency Diseases (5) · Chronic Disease (4) · Disease Attributes (4) · Genetic Diseases, Inborn (4) · Genetic Diseases, X-Linked (4) · Immune System Diseases (4) · Immunologic Deficiency Syndromes (4) · Leukocyte Disorders (4) · Lymphatic Diseases (4) · Pathologic Processes (4)
Stem Cell Transplantation (2) · Hematopoietic Stem Cell Transplantation (1) · Melphalan (1) · Thiotepa (1) · fludarabine (1)
Children's Hospital Los Angeles (1) · Medical College of Wisconsin (1) · Paul Szabolcs (1) · University Hospital, Bordeaux (1) · Washington University School of Medicine (1)
United States (4) · Canada (1) · France (1)
Hisham Abdel-Azim, MD (1) · Mary Horowitz, MD, MS (1) · Paul Szabolcs, MD (1)
PMID 29635077, PMID 31599480, PMID 33152483, PMID 37042921
2014 (1), U10HL069294 (1), U24CA076518 (1)