7 completed, 2 active not recruiting, 2 terminated, 2 unknown. 5 Phase 3, 3 Phase 4, 2 Not applicable, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 4, Not yet recruiting 1 |
| Phase 4 | 3 | Completed 3 |
| Not applicable | 2 | Terminated 2 |
| Phase 2 | 1 | Active not recruiting 1 |
Follow Bruton type agammaglobulinemia: new trials by email Literature Review of Bruton type agammaglobulinemia trials Research Report on Bruton type agammaglobulinemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IVIG Boya: Safety, Efficacy, and Pharmacokinetics Boya IVIG - Primary Immunodeficiency Disease | Phase 3 | Not yet recruiting | Azidus Brasil | 50 | 2026-09-01 | 2026-06-03 |
| Analysis of the Role of IgE Proteoforms in Health and Disease Blood sample collection - Anaphylaxis, Mastocytosis | Recruiting | KU Leuven | 200 | 2025-01-01 | 2026-01-09 | |
| COVID-19 Vaccine Responses in PIDD Subjects X-linked Agammaglobulinemia, XLA | Active not recruiting | Duke University | 100 | 2021-09-30 | 2025-06-03 | |
| Assessment of Immunogenicity of Zostavax® in Patients With Antibody Deficiency 60 Years of Age and Older Zostavax® - Common Variable Immune Deficiency, Specific Antibody Deficiency | Not applicable | Terminated | University of South Florida | 2 | 2015-12-01 | 2018-05-31 |
| Pharmacokinetics (PK) and Safety of Subgam-VF in Primary Immunodeficiency Diseases Subgam - Primary Immune Deficiency Disorders, Common Variable Immunodeficiency | Phase 3 | Completed | Bio Products Laboratory | 38 | 2015-08-20 | 2018-09-12 |
| Mutation of the BTK Gene and Genotype-phenotype Correlation of Chinese Patients With X-Linked Agammaglobulinemia Agammaglobulinemia, BTK | Unknown | Shanghai Children's Medical Center | 100 | 2014-09-01 | 2014-09-09 | |
| Bioequivalence Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Gammaplex® 10 and Gammaplex® 5% in Primary Immunodeficiency Diseases Gammaplex (5%), Gammaplex 10 - Primary Immune Deficiency Disorders, Common Variable Immunodeficiency | Phase 3 | Completed | Bio Products Laboratory | 48 | 2014-02-01 | 2017-03-29 |
| Immune Disorder HSCT Protocol Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan - Immune Deficiency Disorders, Severe Combined Immunodeficiency | Phase 2 | Active not recruiting | Washington University School of Medicine | 20 | 2013-04-29 | 2026-02-19 |
| A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency Gammaplex - Primary Immune Deficiency Disorders, Common Variable Immunodeficiency | Phase 4 | Completed | Bio Products Laboratory | 25 | 2011-03-01 | 2014-12-23 |
| Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Flebogamma 5% DIF - Primary Immune Deficiency Disease | Phase 4 | Completed | Instituto Grifols, S.A. | 24 | 2008-05-01 | 2017-02-02 |
| Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy Human Normal Immunoglobulin for Subcutaneous Administration (IGSC) - Common Variable Immunodeficiency, X-linked Agammaglobulinemia | Phase 3 | Completed | CSL Behring | 51 | 2007-09-01 | 2011-09-01 |
| Efficacy and Safety of Vivaglobin® in Previously Untreated Patients With Primary Immunodeficiency Vivaglobin - Common Variable Immunodeficiency, Agammaglobulinemia | Phase 4 | Completed | CSL Behring | 18 | 2007-03-01 | 2013-06-20 |
| A Clinical Study of Intravenous Immunoglobulin Immune Globulin Intravenous (Human) Omr-IgG-am IGIV - Immunologic Deficiency Syndromes | Phase 3 | Completed | FFF Enterprises | 57 | 2006-11-01 | 2014-08-11 |
| Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies anti-thymocyte globulin, busulfan, cyclophosphamide - Immunologic Deficiency Syndromes, Chediak-Higashi Syndrome | Not applicable | Terminated | Fairview University Medical Center | 2000-03-01 | 2009-10-15 | |
| Study of Genetic and Molecular Defects in Primary Immunodeficiency Disorders X-Linked Agammaglobulinemia, X-Linked Hyper IgM Syndrome | Unknown | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 1995-07-01 | 2005-06-24 |
Common Variable Immunodeficiency (11) · Primary Immunodeficiency Diseases (9) · Hyper-IgM Immunodeficiency Syndrome (6) · Wiskott-Aldrich Syndrome (5) · Immune System Diseases (3) · Immunologic Deficiency Syndromes (3) · Chediak-Higashi Syndrome (2) · Communicable Diseases (2) · Genetic Diseases, Inborn (2) · Granulomatous Disease, Chronic (2) · Hyper-IgM Immunodeficiency Syndrome, Type 1 (2) · Leukocyte-Adhesion Deficiency Syndrome (2) · Lymphohistiocytosis, Hemophagocytic (2) · Lymphoproliferative Disorders (2)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Immune System Diseases (11) · Immunologic Deficiency Syndromes (10) · Blood Protein Disorders (9) · Genetic Diseases, Inborn (9) · Hemic and Lymphatic Diseases (9) · Dysgammaglobulinemia (8) · Hematologic Diseases (8) · Blood Coagulation Disorders (5) · Blood Coagulation Disorders, Inherited (5) · Cytopenia (5) · Genetic Diseases, X-Linked (5) · Hemorrhagic Disorders (5) · Leukocyte Disorders (5) · Leukopenia (5)
gamma-Globulins (5) · Antilymphocyte Serum (1) · Busulfan (1) · Cyclophosphamide (1) · Cyclosporine (1) · Etoposide (1) · Herpes Zoster Vaccine (1) · Hizentra (1) · Immunoglobulins, Intravenous (1) · Melphalan (1) · Methotrexate (1) · Methylprednisolone (1) · Prednisone (1) · Thiotepa (1) · Vivaglobin (1)
Bio Products Laboratory (3) · CSL Behring (2) · Azidus Brasil (1) · Duke University (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · FFF Enterprises (1) · Fairview University Medical Center (1) · Instituto Grifols, S.A. (1) · KU Leuven (1) · Shanghai Children's Medical Center (1) · University of South Florida (1) · Washington University School of Medicine (1)
United States (10) · Canada (2) · Germany (2) · Italy (2) · Spain (2) · United Kingdom (2) · Belgium (1) · Chile (1) · China (1) · France (1) · Hungary (1) · Israel (1) · Poland (1) · Romania (1) · Sweden (1)
Eric Wolford (2) · Akhilesh Chouksey, MD (1) · Chaim Roifman, MD (1) · Daniel Suez, MD (1) · Don McNeil, MD (1) · Eyal Grunebaum, MD (1) · Gordan L Sussman, MD (1) · Hans D. Ochs (1) · Isaac R Melamed, MD (1) · James Moy, MD (1) · Jennifer Leiding, MD (1) · John Sleasman, MD (1) · K. Scott Baker (1) · Kristina De Paris, PhD (1) · Luciana Ferrara (1)
PMID 36818468, PMID 21674136, PMID 21705277, PMID 21932110, PMID 31599480, PMID 39271296, PMID 39919133, PMID 41773292
R21AI168980 (1)