19 completed, 6 unknown, 3 recruiting, 2 active not recruiting. 8 Phase 3, 7 Phase 2, 4 Phase 1, 3 Not applicable, 3 Phase 4.
Follow Dysgammaglobulinemia: new trials by email Literature Review of Dysgammaglobulinemia trials Research Report on Dysgammaglobulinemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD) Hematopoietic stem cell transplant (HSCT) - Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder | Phase 2 | Recruiting | Paul Szabolcs | 25 | 2026-05-04 | 2026-05-15 |
| A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders AMPD3, OMIM*102772, AMP Deaminase Deficiency, AK1, OMIM *103000, Adenylate Kinase Deficiency | Recruiting | National Human Genome Research Institute (NHGRI) | 999 | 2023-12-19 | 2026-08-19 | |
| Bronchiectasis Prevalence in Patients With Primary Humoral Immunodefiency in Champagne-Ardenne Region, France Blood test, chest CT scan - Primary Immunodeficiency, Common Variable Immunodeficiency | Not applicable | Completed | CHU de Reims | 46 | 2022-11-28 | 2025-12-18 |
| Epidemiology of IgA Selective Deficiency - Clinical Manifestations and Risk of Transmission COVID-19 | Unknown | University Hospital, Strasbourg, France | 120 | 2022-04-09 | 2023-12-19 | |
| Immune Response Following COVID-19 Vaccination Rapid antibody test - IgM and IgG in Blood | Unknown | Texas Cardiac Arrhythmia Research Foundation | 500 | 2021-01-15 | 2021-02-03 | |
| Pro-inflammatory Role of Blood Platelets in Critically Ill Patients With Septic Shock. Septic shock, Systemic Inflammatory Response Syndrome - Septic Shock | Completed | University Hospital, Bordeaux | 202 | 2020-11-09 | 2024-04-26 | |
| Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC data collection - Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes | Recruiting | Paul Szabolcs | 50 | 2020-08-20 | 2026-01-13 | |
| A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies CDX-1140, CDX-301, pembrolizumab - Melanoma, Non-small Cell Lung Cancer | Phase 1 | Completed | Celldex Therapeutics | 132 | 2017-12-01 | 2024-03-28 |
| Pharmacokinetics (PK) and Safety of Subgam-VF in Primary Immunodeficiency Diseases Subgam - Primary Immune Deficiency Disorders, Common Variable Immunodeficiency | Phase 3 | Completed | Bio Products Laboratory | 38 | 2015-08-20 | 2018-09-12 |
| Pilot Study Related to the Effect of Clopidogrel on Plasmatic Soluble CD40 Ligand During Systemic Lupus Erythematous Treatment by clopidogrel - Systemic Lupus Erythematous | Phase 1 / Phase 2 | Completed | University Hospital, Bordeaux | 18 | 2015-08-19 | 2026-05-14 |
| Bioequivalence Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Gammaplex® 10 and Gammaplex® 5% in Primary Immunodeficiency Diseases Gammaplex (5%), Gammaplex 10 - Primary Immune Deficiency Disorders, Common Variable Immunodeficiency | Phase 3 | Completed | Bio Products Laboratory | 48 | 2014-02-01 | 2017-03-29 |
| Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204) Hematopoietic Stem Cell Transplant - Hemophagocytic Lymphohistiocytosis, Chronic Active Epstein-Barr Virus Infection | Phase 2 | Completed | Medical College of Wisconsin | 47 | 2013-12-01 | 2022-12-08 |
| IVIG Treatment for Asthmatic Patients With IgG Subclass Deficiency Immune Globulin - Asthma | Phase 3 | Unknown | Ajou University School of Medicine | 30 | 2013-12-01 | 2016-05-02 |
| PNEUMOCELL - Conjugated Pneumococcal Vaccination in Patients With Immunoglobulin G-deficiency Prevenar13 - IgG Deficiency | Phase 2 | Completed | Karolinska University Hospital | 20 | 2013-05-01 | 2014-06-16 |
| Immune Disorder HSCT Protocol Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan - Immune Deficiency Disorders, Severe Combined Immunodeficiency | Phase 2 | Active not recruiting | Washington University School of Medicine | 20 | 2013-04-29 | 2026-02-19 |
| Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies Alemtuzumab 0.3 mg, Cyclophosphamide, Busulfan - SCID, Omenn's Syndrome | Not applicable | Active not recruiting | Masonic Cancer Center, University of Minnesota | 57 | 2012-09-04 | 2026-06-17 |
| 300 Antibody Diagnostic Test Kit Acute Bacterial Infections, Acute Viral Infections | Unknown | The Plasma Source | 300 | 2012-08-01 | 2012-07-20 | |
| A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency Gammaplex - Primary Immune Deficiency Disorders, Common Variable Immunodeficiency | Phase 4 | Completed | Bio Products Laboratory | 25 | 2011-03-01 | 2014-12-23 |
| Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells Hematopoietic stem cell transplantation - Sickle Cell Disease, Thalassemia | Phase 1 / Phase 2 | Completed | Children's Hospital Los Angeles | 25 | 2008-08-01 | 2016-06-23 |
| Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Flebogamma 5% DIF - Primary Immune Deficiency Disease | Phase 4 | Completed | Instituto Grifols, S.A. | 24 | 2008-05-01 | 2017-02-02 |
Showing 20 of 32. Sign in to see all of them.
Hyper-IgM Immunodeficiency Syndrome (18) · Common Variable Immunodeficiency (14) · Primary Immunodeficiency Diseases (10) · Wiskott-Aldrich Syndrome (10) · Bruton type agammaglobulinemia (8) · IgG Deficiency (8) · Granulomatous Disease, Chronic (7) · Immunologic Deficiency Syndromes (6) · Chediak-Higashi Syndrome (5) · Lymphohistiocytosis, Hemophagocytic (5) · Severe Combined Immunodeficiency (5) · Agammaglobulinemia (4) · Hyper-IgM Immunodeficiency Syndrome, Type 1 (4) · Lymphoproliferative Disorders (4) · Genetic Diseases, Inborn (3)
Blood Protein Disorders (32) · Hemic and Lymphatic Diseases (32) · Hematologic Diseases (31) · Immune System Diseases (29) · Immunologic Deficiency Syndromes (26) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (23) · Genetic Diseases, Inborn (20) · Genetic Diseases, X-Linked (15) · Primary Immunodeficiency Diseases (13) · Leukocyte Disorders (12) · Lymphatic Diseases (12) · Blood Coagulation Disorders (10) · Blood Coagulation Disorders, Inherited (10) · Cytopenia (10)
Immunoglobulins, Intravenous (5) · gamma-Globulins (5) · Stem Cell Transplantation (3) · Busulfan (2) · Cyclophosphamide (2) · Melphalan (2) · 13-valent pneumococcal vaccine (1) · Alemtuzumab (1) · Anti-Bacterial Agents (1) · Antilymphocyte Serum (1) · B-Cell Activating Factor (1) · Cyclosporine (1) · Data Collection (1) · Drug Therapy (1) · Etoposide (1)
Bio Products Laboratory (4) · CSL Behring (3) · National Human Genome Research Institute (NHGRI) (2) · Paul Szabolcs (2) · University Hospital, Bordeaux (2) · Ajou University School of Medicine (1) · CHU de Reims (1) · Celldex Therapeutics (1) · Children's Hospital Los Angeles (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · FFF Enterprises (1) · Fairview University Medical Center (1) · Instituto Grifols, S.A. (1) · Karolinska University Hospital (1) · Masonic Cancer Center, University of Minnesota (1)
United States (23) · France (4) · Canada (2) · Chile (1) · Hungary (1) · Israel (1) · Netherlands (1) · Sweden (1) · United Kingdom (1)
Eric Wolford (2) · Paul Szabolcs, MD (2) · Akhilesh Chouksey, MD (1) · Andrea Natale (1) · Ashish K Jain, M.D. (1) · Chaim Roifman, MD (1) · Daniel Suez, MD (1) · Don McNeil, MD (1) · E AM Sanders, PhD, MD (1) · Elizabeth K Garabedian, R.N. (1) · Eyal Grunebaum, MD (1) · Gordan L Sussman, MD (1) · Hans D. Ochs (1) · Hisham Abdel-Azim, MD (1)
PMID 36818468, PMID 17479360, PMID 18814020, PMID 19218820, PMID 20217199, PMID 21725047, PMID 28410816, PMID 29635077, PMID 31599480, PMID 33152483, PMID 37042921, PMID 39271296, PMID 39919133, PMID 41773292
2014 (1), U10HL069294 (1), U24CA076518 (1)