10 unknown, 9 completed, 4 recruiting, 3 terminated. 9 Phase 2, 5 Not applicable, 2 Phase 1, 2 Phase 3, 2 Phase 4.
Follow Hilar Cholangiocarcinoma: new trials by email Literature Review of Hilar Cholangiocarcinoma trials Research Report on Hilar Cholangiocarcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma (POELH-III) Registration of all findings during preoperative Endoscopic Ultrasound - Hilar Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma (Icc) | Recruiting | Erasmus Medical Center | 250 | 2026-02-05 | 2026-09-10 | |
| Diagnostic Accuracy of Eus Fnb in Difficult to Reach Lesions Hilar Cholangiocarcinoma, Duodenal Neoplasms | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 131 | 2025-10-01 | 2026-06-02 | |
| Phase II Study of Neoadjuvant Tislelizumab Plus Radiotherapy and GP Chemotherapy for Borderline/Unresectable Hilar Cholangiocarcinoma Stereotactic Body Radiotherapy (SBRT), Tislelizumab, Gemcitabine - Cholangiocarcinoma, Hilar Cholangiocarcinoma | Phase 2 | Recruiting | Jinbo Yue | 38 | 2025-07-01 | 2026-10-15 |
| Toripalimab Combined With Capecitabine as Postoperative Adjuvant Therapy for Patients With Resectable Advanced Extrahepatic Biliary Tract Cancer Capecitabine, Toripalimab - Gallbladder Cancer, Hilar Cholangiocarcinoma | Phase 2 | Active not recruiting | Tianjin Medical University Cancer Institute and Hospital | 110 | 2024-11-12 | 2024-12-05 |
| Treatment of Non-resectable Bile Duct Cancer with Radiofrequency Ablation or Photodynamic Therapy Photosensitizer, Radiofrequency ablation (RFA) - Hilar Cholangiocarcinoma | Phase 4 | Recruiting | University of Leipzig | 258 | 2023-02-10 | 2025-03-27 |
| MRI-based Clinico-radiomics Predicting Lymph Node Metastasis Status of Hilar Cholangiocarcinoma No interventions - Hilar Cholangiocarcinoma | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 60 | 2022-11-20 | 2022-11-23 | |
| Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma Endoscopic Ultrasound registration - Hilar Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma | Completed | Erasmus Medical Center | 245 | 2022-09-05 | 2025-08-08 | |
| Immunotherapy With Durva and Treme With or Without Capecitabine in Adjuvant Treatment for Biliary Tract Cancer Durvalumab, Tremelimumab, Capecitabine - Biliary Tract Cancer (CCA), Intrahepatic Cholangiocarcinoma | Phase 2 | Completed | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | 40 | 2022-05-23 | 2025-05-01 |
| Endoscopic Scissors Cutting Nasobiliary Duct VS Bilateral Plastic Stent Endoscopic nasobiliary duct cutting, Bilateral plastic stent - Cholangiocarcinoma, Hilar, Biliary Stricture | Not applicable | Unknown | First People's Hospital of Hangzhou | 122 | 2022-01-01 | 2023-10-30 |
| I-125 Seeds Loaded Stent Insertion for Inoperable Hilar Cholangiocarcinoma I-125 seeds loaded stent (self-expanded metal stent with I-125 seeds, Micro-Tech, Nanjing, China), Normal stent (self-expanded metal stent without I-125 seeds, Micro-Tech, Nanjing, China) - Hilar Cholangiocarcinoma | Not applicable | Unknown | Xuzhou Central Hospital | 100 | 2021-04-01 | 2021-07-14 |
| Feasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer Multi-Platform Profiling with Organoid Drug Sensitivity Screening and ctDNA Monitoring - Biliary Tract Cancer, Cholangiocarcinoma | Terminated | University of Washington | 14 | 2020-07-08 | 2025-07-10 | |
| Efficacy of Intraductal Radiofrequency Ablation in Combination With Metallic Biliary Stenting in Advanced Hilar Cholangiocarcinoma ELRA endoluminal radiofrequency ablation electrode (Taewoong, Seoul, Korea) - Hilar Cholangiocarcinoma, Biliary Obstruction | Not applicable | Completed | Department of Medical Services Ministry of Public Health of Thailand | 70 | 2020-04-01 | 2022-03-23 |
| A Cell-free DNA Methylation Blood-Based Test for Biliary Tract Cancers Screening Gall Bladder Cancer, Intrahepatic Cholangiocarcinoma (Icc) | Recruiting | Yingbin Liu, MD, PhD, FACS | 1800 | 2020-01-01 | 2025-09-16 | |
| Fluorescence Image Guided Surgery in Cholangiocarcinoma Bevacizumab-IRDye800CW, near infrared (NIR) fluorescence imaging - Hilar Cholangiocarcinoma | Phase 1 / Phase 2 | Unknown | University Medical Center Groningen | 12 | 2019-04-01 | 2021-04-28 |
| Tampa Associating Microwave Liver Ablation With Portal Vein Ligation for Staged Hepatectomy (TAMLAPS) Liver Cancer, Liver Tumor | Unknown | Florida Hospital Tampa Bay Division | 10 | 2018-07-18 | 2018-11-13 | |
| Superior Bilioenteric Anastomosis by Magnetic Compressive Technique Magnetic Compressive Anastomosis, Manual Anastomosis - Hilar Cholangiocarcinoma, Bile Duct Injury | Not applicable | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 70 | 2017-07-01 | 2017-09-21 |
| Efficacy and Safety Study of PDT Using Deuteporfin for Unresectable Advanced Perihilar Cholangiocarcinoma PDT-Deuteporfin（6 hour), PDT-Deuteporfin（9 hour), stenting - Hilar Cholangiocarcinoma | Phase 2 | Terminated | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | 7 | 2017-05-17 | 2019-07-17 |
| Impact of Three-dimensional Visualization on Operation Strategy and Complications for Hilar Cholangiocarcinoma Hilar Cholangiocarcinoma | Unknown | Zhujiang Hospital | 300 | 2017-03-15 | 2018-04-19 | |
| Efficacy and Safety Study of PDT Using Photofrin in Unresectable Advanced Perihilar Cholangiocarcinoma (OPUS) Photodynamic therapy-Photofrin, Stenting procedure, Chemotherapy regimen - Hilar Cholangiocarcinoma | Phase 3 | Terminated | Concordia Laboratories Inc. | 28 | 2014-11-12 | 2019-08-28 |
| RALPPS in Patients With Hilar and Intrahepatic Cholangiocarcinoma RALPPS, portal vein embolization + major liver resection - Hilar Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma | Completed | Moscow Clinical Scientific Center | 30 | 2014-09-15 | 2017-10-25 |
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Klatskin Tumor (27) · Cholangiocarcinoma (11) · Gallbladder Neoplasms (6) · Bile Duct Neoplasms (5) · Biliary Tract Neoplasms (4) · Carcinoma, Hepatocellular (3) · Cirrhosis, Familial, with Pulmonary Hypertension (2) · Common Bile Duct Neoplasms (2) · Adenocarcinoma (1) · Bile Duct Diseases (1) · Carcinoma (1) · Cholangitis, Sclerosing (1) · Choledochal Cyst (1) · Disease (1) · Duodenal Neoplasms (1)
Neoplasms (27) · Neoplasms by Histologic Type (27) · Neoplasms, Glandular and Epithelial (27) · Adenocarcinoma (26) · Carcinoma (26) · Digestive System Diseases (17) · Cholangiocarcinoma (16) · Biliary Tract Diseases (14) · Digestive System Neoplasms (14) · Neoplasms by Site (14) · Bile Duct Diseases (9) · Biliary Tract Neoplasms (7) · Gallbladder Diseases (7) · Pathological Conditions, Signs and Symptoms (5) · Pathologic Processes (4)
Capecitabine (4) · Cisplatin (2) · Gemcitabine (2) · Drug Therapy (1) · Erlotinib Hydrochloride (1) · Fluorouracil (1) · Leucovorin (1) · Liver Transplantation (1) · Neoadjuvant Therapy (1) · Optical Imaging (1) · Oxaliplatin (1) · Photochemotherapy (1) · Photosensitizing Agents (1) · Radiofrequency Ablation (1) · Radiosurgery (1)
Erasmus Medical Center (2) · National Cancer Institute (NCI) (2) · Air Force Military Medical University, China (1) · Azienda Ospedaliera di Padova (1) · Centre Hospitalier Universitaire, Amiens (1) · Concordia Laboratories Inc. (1) · Department of Medical Services Ministry of Public Health of Thailand (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · First People's Hospital of Hangzhou (1) · Florida Hospital Tampa Bay Division (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest (1) · Jinbo Yue (1) · Khon Kaen University (1) · Moscow Clinical Scientific Center (1)
China (11) · United States (5) · Germany (3) · Netherlands (3) · Italy (2) · Thailand (2) · Belgium (1) · Canada (1) · France (1) · South Korea (1) · Switzerland (1)
Albrecht Hoffmeister, Prof.Dr.med. (1) · Anthony El-Khoueiry (1) · Bo Zhang (1) · Chao Liu, PhD (1) · Cristiano Spada, Professor (1) · Enrico Gringeri, MD (1) · G. M. van Dam, MD, PhD (1) · Gentry King, MD (1) · Guohong Han, MD,Ph.D (1) · Jianfeng Yang, Doctor (1) · Jinbo Yue (1) · M. T. de Boer, MD, PhD (1) · Michel Kahaleh, MD (1) · Mikhail Efanov (1)
PMID 1294807, PMID 15824939, PMID 15849514, PMID 16632990, PMID 18161934, PMID 19393505, PMID 20700608, PMID 22207929, PMID 22595446, PMID 22895398, PMID 28991876, PMID 33259690, PMID 33430020, PMID 35081535, PMID 36372281, PMID 38477985, PMID 40068597, PMID 8912621
U10CA032102 (2), U10CA180888 (1)