22 completed, 21 unknown, 18 recruiting, 6 not yet recruiting. 27 Not applicable, 18 Phase 2, 7 Phase 1, 4 Phase 3, 4 Phase 4.
Follow Klatskin Tumor: new trials by email Literature Review of Klatskin Tumor trials Research Report on Klatskin Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prognostic Evaluation and Systematic Re-Assessment of Cholangiocarcinoma Therapy Intrahepatic Cholangiocarcinoma, Perihilar Cholangiocarcinoma | Not yet recruiting | Karolinska University Hospital | 900 | 2026-09-01 | 2026-09-11 | |
| Safety and Efficacy of CD160-Enhanced Autologous Antigen-Specific T-Cells (BTC-Ag-T) in Advanced Biliary Tract Cancer BTC-Ag-T (ACH-AgT001), Cyclophosphamide and Fludarabine - Biliary Tract Neoplasms, Cholangiocarcinoma, Intrahepatic | Phase 1 | Recruiting | Shanghai Zhongshan Hospital | 18 | 2026-05-01 | 2026-05-29 |
| Neoadjuvant Gemcitabine and Cisplatin in Combination With Perioperative Pembrolizumab Versus Upfront Surgery for Patients With Primary Resectable and Borderline Resectable Perihilar and Distal Cholangiocarcinoma Pembrolizumab, Gemcitabine, Cisplatin - Extrahepatic Cholangiocarcinoma, Perihilar Cholangiocarcinoma | Phase 2 / Phase 3 | Recruiting | Amsterdam UMC, location VUmc | 150 | 2026-04-17 | 2026-08-25 |
| Effect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma Injection of 37℃ contrast agent - Cholangitis | Not applicable | Not yet recruiting | Hepatopancreatobiliary Surgery Institute of Gansu Province | 100 | 2026-04-01 | 2025-12-26 |
| Preoperative Right Hepatic Artery Embolization for Locally Advanced Bismuth IIIb and IV Perihilar Cholangiocarcinoma Preoperative Right Hepatic Artery Embolization - Cholangiocarcinoma Non-resectable | Not applicable | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 33 | 2026-04-01 | 2026-11-09 |
| TRACE-BTC. Relation of Biomarkers and Patients Reported Quality of Life to Outcomes in Patients With Biliary Tract Cancer: a Real- World Cohort Biliary Tract Cancer (BTC), Biliary Tract Cancer (CCA) | Not yet recruiting | Aarhus University Hospital | 300 | 2026-03-15 | 2026-03-06 | |
| Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma (POELH-III) Registration of all findings during preoperative Endoscopic Ultrasound - Hilar Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma (Icc) | Recruiting | Erasmus Medical Center | 250 | 2026-02-05 | 2026-09-10 | |
| Volume-Restricted Resection for Perihilar Cholangiocarcinoma Cholangiocarcinoma, Hilar | Not yet recruiting | Yongjun Chen | 300 | 2026-01-01 | 2025-09-02 | |
| Impact of Vascular Resection on Survival and Postoperative Outcomes in Patients With Hilar Cholangiocarcinoma: A Retrospective Study No Intervention: Observational Cohort - Cholangiocarcinoma, Hilar | Not yet recruiting | Yongjun Chen | 300 | 2025-12-01 | 2025-12-31 | |
| Diagnostic Accuracy of Eus Fnb in Difficult to Reach Lesions Hilar Cholangiocarcinoma, Duodenal Neoplasms | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 131 | 2025-10-01 | 2026-06-02 | |
| Phase II Study of Neoadjuvant Tislelizumab Plus Radiotherapy and GP Chemotherapy for Borderline/Unresectable Hilar Cholangiocarcinoma Stereotactic Body Radiotherapy (SBRT), Tislelizumab, Gemcitabine - Cholangiocarcinoma, Hilar Cholangiocarcinoma | Phase 2 | Recruiting | Jinbo Yue | 38 | 2025-07-01 | 2026-10-15 |
| Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma Perihilar Cholangiocarcinoma, Klatskin Tumor | Recruiting | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 8 | 2025-06-01 | 2025-05-23 | |
| En Bloc Resection of the Liver and Pancreas With a "Non-touch" Technique Followed by Liver Transplantation to Improve the Overall Survival in Patients With Non-resectable Hilar Cholangiocarcinoma Beyond the Mayo Clinic Transplant Criteria Liver transplantation after en bloc resection of the liver and pancreas - Cholangiocarcinoma Non-resectable, Cholangiocarcinoma Recurrent | Not applicable | Recruiting | Oslo University Hospital | 15 | 2025-01-01 | 2025-08-21 |
| Perioperative Treatment of High-risk Resectable CCA With HAIC Plus A+T: Neobrave CCA Gemcitabine Oxaliplatin and 5FU - Intrahepatic Cholangiocarcinoma (Icc), Perihilar Cholangiocarcinoma | Phase 2 | Terminated | Peking University | 1 | 2024-12-31 | 2026-01-28 |
| Toripalimab Combined With Capecitabine as Postoperative Adjuvant Therapy for Patients With Resectable Advanced Extrahepatic Biliary Tract Cancer Capecitabine, Toripalimab - Gallbladder Cancer, Hilar Cholangiocarcinoma | Phase 2 | Active not recruiting | Tianjin Medical University Cancer Institute and Hospital | 110 | 2024-11-12 | 2024-12-05 |
| A Novel Serological Risk Model for Early Non-invasive Diagnosis of Cholangiocarcinoma No interventions - Cholangiocarcinoma | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 60 | 2024-11-01 | 2024-10-26 | |
| Endoscopic Radiofrequency Ablation for Unresectable Cholangiocarcinoma Intraductal biliary radiofrequency ablation - Cholangiocarcinoma, Klatskin Tumor | Not applicable | Recruiting | Universitätsklinikum Hamburg-Eppendorf | 130 | 2024-08-30 | 2026-09-09 |
| Stereotactic Body Radiation Therapy After Chemotherapy for Unresectable Perihilar Cholangiocarcinoma Stereotactic body radiation therapy - Klatskin Tumor | Not applicable | Recruiting | Erasmus Medical Center | 30 | 2024-07-01 | 2025-07-15 |
| Robotically Assisted Surgery For Perihilar Cholangiocarcinoma: A Prospective Study Major hepatectomy - Cholangiocarcinoma Cancer, Perihilar Cholangiocarcinoma | Recruiting | Azienda Ospedaliera di Padova | 32 | 2024-06-07 | 2024-12-06 | |
| NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma Biospecimen Collection, Computed Tomography, Heat Shock Factor 1 Pathway Inhibitor NXP800 - Advanced Cholangiocarcinoma, Metastatic Cholangiocarcinoma | Phase 1 | Terminated | Mayo Clinic | 7 | 2024-05-31 | 2025-12-22 |
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Cholangiocarcinoma (35) · Gallbladder Neoplasms (13) · Bile Duct Neoplasms (9) · Biliary Tract Neoplasms (8) · Carcinoma, Hepatocellular (6) · Cholangitis (4) · Cirrhosis, Familial, with Pulmonary Hypertension (3) · Disease (3) · Liver Neoplasms (3) · Common Bile Duct Neoplasms (2) · Jaundice, Obstructive (2) · Neoplasms (2) · Adenocarcinoma (1) · Bile Duct Diseases (1)
Neoplasms by Histologic Type (80) · Neoplasms, Glandular and Epithelial (80) · Adenocarcinoma (79) · Carcinoma (79) · Neoplasms (78) · Cholangiocarcinoma (45) · Digestive System Diseases (34) · Biliary Tract Diseases (29) · Digestive System Neoplasms (27) · Neoplasms by Site (27) · Bile Duct Diseases (17) · Biliary Tract Neoplasms (14) · Gallbladder Diseases (14) · Pathological Conditions, Signs and Symptoms (12) · Pathologic Processes (9)
Capecitabine (6) · Cisplatin (6) · Gemcitabine (6) · Fluorouracil (4) · Liver Transplantation (4) · Magnetic Resonance Spectroscopy (3) · Oxaliplatin (3) · Radiosurgery (3) · Specimen Handling (3) · 1,2-diaminocyclohexaneplatinum II citrate (2) · 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide (2) · Biopsy (2) · Leucovorin (2) · Platinum (2) · Self Expandable Metallic Stents (2)
Erasmus Medical Center (4) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (4) · National Cancer Institute (NCI) (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Azienda Ospedaliera di Padova (2) · Central Hospital, Nancy, France (2) · Hepatopancreatobiliary Surgery Institute of Gansu Province (2) · Khon Kaen University (2) · Mayo Clinic (2) · Oslo University Hospital (2) · Peking University (2) · RedHill Biopharma Limited (2) · Shanghai Zhongshan Hospital (2) · Soon Chun Hyang University (2) · Yongjun Chen (2)
China (27) · United States (14) · Netherlands (9) · Germany (7) · Italy (6) · France (5) · South Korea (5) · Belgium (4) · Norway (4) · Thailand (4) · Canada (3) · Australia (2) · Denmark (2) · Hong Kong (2) · Spain (2)
Chao Liu, PhD (3) · Xun Li, M.D., Ph. D. (2) · Ahmet Ayav, PhD (1) · Albrecht Hoffmeister, Prof.Dr.med. (1) · Anthony El-Khoueiry (1) · Ardaman Shergill (1) · Bo Zhang (1) · Cristiano Spada, Professor (1) · Enrico Gringeri, MD (1) · Enrico Gringeri, Prof. (1) · Felix Krenzien (1) · G. M. van Dam, MD, PhD (1)
PMID 28420720, PMID 12838220, PMID 1294807, PMID 15824939, PMID 15849514, PMID 16632990, PMID 18161934, PMID 19393505, PMID 20375404, PMID 20700608, PMID 22207929, PMID 22595446, PMID 22895398, PMID 24769639, PMID 24852116, PMID 26179201, PMID 26598942, PMID 27095655, PMID 27234522, PMID 27806234, PMID 28405328, PMID 28479493, PMID 28818953, PMID 28991876, PMID 29341833, PMID 29433850, PMID 29882997, PMID 30327398, PMID 30515783, PMID 30642373, PMID 30646854, PMID 30755690, PMID 30811474, PMID 30902342, PMID 31081949, PMID 31403867, PMID 31407173, PMID 31501784, PMID 32010755, PMID 33198671, PMID 33259690, PMID 33430020, PMID 34439146, PMID 35081535, PMID 36372281, PMID 37138243, PMID 37684688, PMID 37713527, PMID 38477985, PMID 39090600
U10CA032102 (2), 2023 (1), P30CA015083 (1), P30CA036727 (1), P30CA168524 (1), P50CA127297 (1), U10CA180821 (1), U10CA180888 (1)