Diagnostic Efficacy and Prognostic Value of 18F-FDG PET/CT (MR) in Pediatric Solid Blastoma

NCT06190574 — Completed, 50 participants, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

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Registry	NCT06190574
Status	Completed
Study type	Observational
Enrollment	50 (Actual)
Sponsor	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (Other)
Conditions	18F-FDG, Neuroblastoma, Hepatoblastoma, Wilms Tumor
Interventions	Telephone follow-up (Other)
Dates	start 2021-07-30, primary completion 2023-09-30, completion 2023-11-30, first posted 2024-01-05, last updated 2024-03-19
Locations	1 site in China

-Summary

the primary histologic origin of extracranial solid tumors in children is malignant embryonic cells, including Neuroblastoma (NB) , Hepatoblastoma(HB), and kidney, wilms' tumor(WT). Their main clinical symptoms are large abdominal masses, the most common lymph node metastasis . NB accounts for 15% of childhood cancer deaths, but some low-risk NB can disappear on its own. The International Neuroblastoma Risk Group Staging System (INRGSS) was used to determine Risk before NB treatment, whereas the INRGSS was entirely based on the Neuroblastoma diagnosis, illustrating the importance of imaging in the assessment of NB.18F-FDG is the most commonly used agent in PET imaging of tumor. It can reflect the glucose metabolism of tumor and is widely used in the diagnosis, staging, evaluation of curative effect and prognosis prediction of tumor In this study, the investigators retrospectively analyzed 18F-FDG PET/CT or PET/MRI images from patients with NB, HB, and WT. The investigators sought to assess whether these images provide useful information for diagnosis and prognosis.

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+Arms and interventions

Telephone follow-up (Other): Telephone follow-up

+Outcome measures

Primary outcomes

Region of Interest (ROI) [up to 2 years]: The presence of non-physiological uptake or uptake in a tissue structure can be considered pathological. The lesion intake is higher than the health organization and is classified as clearly positive. The lesion and the surrounding normal tissue ROI, measure the SUV, TLG and MTV.
Sensitivity and specificity of diagnosis and staging [up to 2 years]: Comparison of the high uptake portion of a pet image suspected to be a histiocytoma for consistency with pathological findings, using the pathological section as the gold standard to calculate the sensitivity and specificity of the diagnostic.

+Eligibility

Sex: All, ages: any to 18 Years

Inclusion Criteria:

1. age < 18 years,
2. have pathological results or definite clinical diagnosis as the gold standard.

Exclusion Criteria：

1. had surgery or chemotherapy before imaging,
2. accompanying other tumors,
3. diabetic patients or patients with fasting blood glucose ≥ 200 mg/dL.

+Locations (1)

Facility	City	Country	Status
China, Hubei Province	Wuhan, Hubei	China

+Publications

Results publication: Hu W, Qu B, Song Y, Li M, Qin C, Lan X. Characteristics and prognostic value of pre-treatment 18F-FDG PET in neuroblastoma. Eur J Nucl Med Mol Imaging. 2026 Jun 5. doi: 10.1007/s00259-026-07977-1. Online ahead of print. PMID 42246993

+Investigators

Xiaoli Lan, PhD, Principal investigator, Study Principal Investigator Wuhan Union Hospital, China