145 completed. 145 Phase 1, 26 Phase 2.
By phase and status
Follow Hepatitis B: new trials by email Literature Review of Hepatitis B trials Research Report on Hepatitis B
Trials (filtered) newest first · largest first
All 145 trials
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix .
Trial Phase Status Sponsor Enrollment Start Updated
Single Dose Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Pevifoscorvir Sodium (ALG-000184) in Participants With Renal Impairment and in Healthy Participants With Normal Renal Function Pevifoscorvir Sodium (ALG-000184) - Chronic Hepatitis B Infection Phase 1 Completed 12 2026-03-10 2026-08-21 A Study to Evaluate the Safety and Immunogenicity of an Investigational Vaccine for Chronic Hepatitis B Virus Infection, in Healthy Adults AVX70371, Placebo - Chronic Hepatitis b Phase 1 Completed 16 2025-05-06 2026-10-08 A Clinical Study of HH-006 in Untreated Chronic Hepatitis B Virus Infected Patients HH-006, 0.9% normal saline - Chronic Hepatitis B Virus Infection Phase 1 Completed 36 2024-12-20 2026-04-07 Study to Evaluate the Effect of Bepirovirsen on Cardiac Conduction as Assessed by 12-lead Electrocardiogram in Healthy Volunteers Bepirovirsen, Placebo - Hepatitis B Phase 1 Completed 46 2024-07-18 2026-07-10 A Study of BW-20507 in Chinese Healthy Subjects and Subjects With Chronic Hepatitis B Placebo, BW-20507 - Chronic Hepatitis B Phase 1 Completed 32 2024-06-24 2026-07-31 A Study to Assess the Safety, Pharmacokinetics, and Antiviral Activity of ABI-4334 in Subjects With Chronic Hepatitis B Virus Infection ABI-4334, Placebo - Chronic Hepatitis B Phase 1 Completed 20 2024-06-04 2025-07-23 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CB06-036 in Subjects With Chronic Hepatitis B CB06-036, Placebo - Chronic Hepatitis b Phase 1 Completed 30 2024-04-22 2025-05-21 The Effects of IL-1 Blockade on Inotrope Sensitivity in Patients With Heart Failure (AID-HEART) Anakinra - Heart Failure Phase 1 Completed 4 2024-02-05 2026-09-04 A Heterologous Protein Prime/MVA Boost Therapeutic Hepatitis B Vaccine Candidate HEPLISAV B; TherVacB, TherVacB - Chronic Hepatitis B Phase 1 Completed 26 2024-01-23 2026-06-04 A Clinical Trial of TQ-A3334 Tablet After Multiple Administration in Adult Subjects TQ-A3334 tablets, TQ-A3334 placebo tablets - Hepatitis B Phase 1 Completed 40 2023-12-26 2024-10-30 A Study to Evaluate the Relative Bioavailability of Subcutaneous Bepirovirsen When Delivered From a Vial or Prefilled Syringe Fitted With a Safety Syringe Device in Healthy Adult Participants Bepirovirsen - Hepatitis B Phase 1 Completed 160 2023-10-04 2025-07-18 Dose-Escalation Prime/Boost Therapeutic Vaccination Study Of 2 Chimp Adenoviral Vectors in Adults With Chronic HBV On Nucleos(t)Ide Therapy VRON-0200-AdC6, VRON-0200-AdC7, VIR-2218 - Chronic Hepatitis B Phase 1 Completed 35 2023-09-26 2026-08-19 Safety, Tolerability, PK & PD of AB-101 Following Oral Administration in Healthy and CHB Subjects. AB-101, Placebo, Nucleos(t)ide Analogue - Chronic Hepatitis b Phase 1 Completed 128 2023-08-30 2026-04-13 A Study to Evaluate the Safety and Efficacy of AHB-137 in Healthy Participants and HBeAg-negative Chronic Hepatitis B (CHB) Patients AHB-137 injection, Placebo - Hepatitis B, Chronic Phase 1 / Phase 2 Completed 129 2023-08-03 2026-05-07 Phase 1 Study of HT-102 Administered Subcustaneously in Healthy Participants and Patients With Chronic Hepatitis B for Safety, Tolerability, Pharmacokinetics (PK), and Antiviral Activity HT-102, Placebo - Chronic Hepatitis B Phase 1 Completed 56 2023-06-12 2026-11-02 A Platform Study to Evaluate Investigational Therapies in Chronic Hepatitis B Infection VIR-3434, VIR-2218, TDF - Hepatitis B, Chronic Phase 1 / Phase 2 Completed 33 2023-05-10 2026-02-09 Study of HBV Therapeutic Vaccines GS-2829 and GS-6779 in Healthy Participants and Participants With Chronic Hepatitis B GS-2829, GS-6779, Placebo - Chronic Hepatitis B Phase 1 Completed 83 2023-04-03 2026-01-23 A Study Evaluating AHB-137 in Healthy Participants and Participants with Chronic Hepatitis B AHB-137 injection, Placebo - Chronic Hepatitis B Phase 1 Completed 64 2023-02-28 2025-02-14 This is a Phase 1 Study in Which Healthy Volunteers and Participants With Chronic HBV Infection Will be Assessed for Safety, Tolerability, Pharmacokinetics (PK), and Antiviral Activity HT-101, Placebo - Chronic Hepatitis b Phase 1 Completed 82 2022-11-22 2026-11-02 A First in Human Study to Assess Safety, Tolerability, Pharmacokinetics of ABI-4334 in Healthy Subjects ABI-4334 Tablet, ABI-4334 Placebo - Chronic Hepatitis B Phase 1 Completed 54 2022-11-11 2023-09-13
Showing 20 of 145. Sign in to see all of them.
Narrower conditions Hepatitis B, Chronic (87) · Hepatitis (8) · Hepatitis C (5) · Liver Diseases (5) · Virus Diseases (4) · Carcinoma, Hepatocellular (2) · Communicable Diseases (2) · DNA Virus Infections (2) · Fibrosis (2) · HIV Infections (2) · Infections (2) · Kidney Failure, Chronic (2) · Acquired Immunodeficiency Syndrome (1) · Acquired angioedema (1)
Broader conditions Blood-Borne Infections (145) · Digestive System Diseases (145) · Hepadnaviridae Infections (145) · Hepatitis, Viral, Human (145) · Communicable Diseases (143) · DNA Virus Infections (143) · Infections (143) · Virus Diseases (141) · Liver Diseases (140) · Hepatitis (137) · Pathologic Processes (94) · Pathological Conditions, Signs and Symptoms (94) · Disease Attributes (91) · Chronic Disease (88) · Hepatitis, Chronic (86)
Interventions entecavir (14) · Tenofovir (10) · peginterferon alfa-2a (10) · Hepatitis B Vaccines (5) · tenofovir alafenamide (4) · Engerix-B (3) · Heplisav-B (3) · Midazolam (3) · adefovir dipivoxil (3) · Aluminum Hydroxide (2) · Drug and Narcotic Control (2) · Itraconazole (2) · NVR 3-778 (2) · Nivolumab (2) · Ritonavir (2)
Sponsors Assembly Biosciences (10) · GlaxoSmithKline (9) · Gilead Sciences (6) · Hoffmann-La Roche (6) · Dynavax Technologies Corporation (4) · Bristol-Myers Squibb (3) · Enanta Pharmaceuticals, Inc (3) · Enyo Pharma (3) · Sunshine Lake Pharma Co., Ltd. (3) · Vir Biotechnology, Inc. (3) · Aligos Therapeutics (2) · Alios Biopharma Inc. (2) · Aribio Lab Co., Ltd. (2) · Barinthus Biotherapeutics (2) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (2)
Countries China (36) · United States (36) · New Zealand (30) · South Korea (27) · Hong Kong (19) · Australia (17) · Taiwan (17) · United Kingdom (16) · Belgium (11) · Singapore (10) · Thailand (10) · Germany (9) · Canada (8) · France (7) · Moldova (7)
Top investigators Benedetta Massetto, M.D. (2) · Junqi Niu (2) · Mamun Al-Mahtab, MD (2) · Yanhua Ding (2) · Yanhua Ding, Doctor (2) · Angela Molga, M.D. FRACP (1) · Anna Lok, M.D. (1)
Results publications PMID 27257978 , PMID 30625297 , PMID 42550463 , PMID 1538192 , PMID 15577929 , PMID 16310901 , PMID 16375711 , PMID 20090916 , PMID 20091678 , PMID 22981147 , PMID 23774433 , PMID 24148552 , PMID 24394187 , PMID 24555998 , PMID 25406369 , PMID 25426834 , PMID 29660190 , PMID 30088198 , PMID 31323705 , PMID 31711752 , PMID 32049318 , PMID 32839221 , PMID 32912268 , PMID 32928858 , PMID 34037271 , PMID 34237271 , PMID 34280012 , PMID 34562067 , PMID 34741731 , PMID 35040959 , PMID 35485346 , PMID 35605429 , PMID 35695169 , PMID 35870702 , PMID 36201354 , PMID 36509100 , PMID 36927420 , PMID 37290591 , PMID 37353450 , PMID 37524230 , PMID 37791379 , PMID 39119977 , PMID 39389081 , PMID 39673713 , PMID 39707469 , PMID 39815989 , PMID 40882923 , PMID 40932107 , PMID 41085094 , PMID 41268712
NIH funding 2017 (3) , 2009 (2) , 2014 (2) , 2016 (2) , 2015 (1) , 2019 (1) , 2025 (1) , P01AI055793 (1) , UM1CA186686 (1)