10 completed. 10 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 10 |
| Phase 1 | 2 | Completed 2 |
Follow Heart Failure With Reduced Ejection Fraction: new trials by email Literature Review of Heart Failure With Reduced Ejection Fraction trials Research Report on Heart Failure With Reduced Ejection Fraction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketones in Heart Failure With Reduced Ejection Fraction ketone ester, placebo - Heart Failure With Reduced Ejection Fraction | Phase 2 | Completed | Duke University | 25 | 2024-03-06 | 2026-09-03 |
| Heart Failure Polypill at a Safety Net Hospital Heart failure polypill, Control Rx - Heart Failure With Reduced Ejection Fraction, HIV Infections | Phase 2 | Completed | University of California, San Francisco | 35 | 2024-02-27 | 2025-12-31 |
| A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF) Tovinontrine (CRD-750), Placebo - Heart Failure, Heart Failure With Reduced Ejection Fraction | Phase 2 | Completed | Cardurion Pharmaceuticals, Inc. | 557 | 2024-02-13 | 2026-09-01 |
| Phase Ib/IIa Trial With AC01 in Patients With HFrEF AC01, Placebo Minitablets - Heart Failure With Reduced Ejection Fraction | Phase 1 / Phase 2 | Completed | AnaCardio AB | 58 | 2023-02-23 | 2026-05-07 |
| EVOlocumab in Stable Heart Failure With Reduced Ejection Fraction of Ischemic Etiology: EVO-HF Pilot Evolocumab - Heart Failure With Reduced Ejection Fraction | Phase 2 | Completed | Fundació Institut Germans Trias i Pujol | 46 | 2018-12-03 | 2023-02-15 |
| v4 Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-491 MYK-491, Placebo - Heart Failure With Reduced Ejection Fraction, Dilated Cardiomyopathy | Phase 1 / Phase 2 | Completed | Bristol-Myers Squibb | 52 | 2018-02-06 | 2023-02-02 |
| Empagliflozin in Heart Failure Patients With Reduced Ejection Fraction Empagliflozin 10 MG, Placebo - Heart Failure With Reduced Ejection Fraction | Phase 2 | Completed | Morten Schou | 190 | 2017-06-29 | 2020-02-05 |
| Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection Fraction 25 mg Omecamtiv Mecarbil, Placebo, 37.5 mg Omecamtiv Mecarbil - Heart Failure With Reduced Ejection Fraction | Phase 2 | Completed | Cytokinetics | 81 | 2016-04-14 | 2021-07-27 |
| VAgal Nerve Stimulation: safeGUARDing Heart Failure Patients Equilia® Vagal Nerve Stimulation - Heart Failure With Reduced Ejection Fraction | Phase 2 | Completed | LivaNova | 15 | 2014-10-07 | 2018-03-13 |
| Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients LCZ696 - Heart Failure With Reduced Ejection Fraction | Phase 2 | Completed | Novartis Pharmaceuticals | 498 | 2013-11-01 | 2015-10-15 |
Heart Failure (4) · Cardiomyopathy, Dilated (1) · Cardiovascular Diseases (1) · HIV Infections (1) · Heart Diseases (1) · Ketosis (1) · Medication Adherence (1) · Motor Activity (1)
Cardiovascular Diseases (4) · Heart Diseases (4) · Behavior (2) · Acid-Base Imbalance (1) · Acidosis (1) · Blood-Borne Infections (1) · Cardiomegaly (1) · Cardiomyopathies (1) · Communicable Diseases (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Genetic Diseases, Inborn (1) · Genital Diseases (1) · Health Behavior (1) · Immune System Diseases (1) · Immunologic Deficiency Syndromes (1)
Tin Fluorides (1) · empagliflozin (1) · evolocumab (1) · formic acid 4-(3-oxobutyl)phenyl ester (1) · omecamtiv mecarbil (1) · sacubitril and valsartan sodium hydrate drug combination (1)
AnaCardio AB (1) · Bristol-Myers Squibb (1) · Cardurion Pharmaceuticals, Inc. (1) · Cytokinetics (1) · Duke University (1) · Fundació Institut Germans Trias i Pujol (1) · LivaNova (1) · Morten Schou (1) · Novartis Pharmaceuticals (1) · University of California, San Francisco (1)
United States (5) · United Kingdom (4) · Germany (3) · Italy (3) · Netherlands (3) · Spain (3) · Belgium (2) · Bulgaria (2) · France (2) · Hungary (2) · Poland (2) · Slovakia (2) · Sweden (2) · Australia (1) · Canada (1)
Albert Hagege, MD, PhD (1) · Colette DeJong, MD (1) · Gail Berman (1) · Jacob E Moller, MD (1) · Lars H Lund, MD PhD (1) · Morten Schou, MD (1) · Priscilla Hsue, MD (1) · Senthil Selvaraj, MD (1)
PMID 27170530, PMID 29164797, PMID 31227014, PMID 33357505, PMID 33404637, PMID 34061581, PMID 34509409, PMID 34743533, PMID 35219331, PMID 35973031, PMID 39843293, PMID 40118491, PMID 40502611, PMID 41711194, PMID 42341796
2017 (2), 2023 (1), K23HL161348 (1)