22 completed, 20 unknown, 10 recruiting, 7 active not recruiting. 20 Phase 2, 11 Phase 1, 6 Not applicable, 2 Phase 3, 1 Phase 4.
Follow Genomic Instability: new trials by email Literature Review of Genomic Instability trials Research Report on Genomic Instability
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Zanzalintinib Alone or in Combination With Pembrolizumab and Berahyaluronidase Alfa in Participants With Colorectal Cancer With Molecular Residual Disease Zanzalintinib, Pembrolizumab (+) Berahyaluronidase alfa, Placebo - Colorectal Cancer | Phase 3 | Recruiting | Exelixis | 600 | 2026-12-18 | 2026-11-12 |
| Neoadjuvant Pembrolizumab With a Watch-and-wait Strategy for dMMR/MSI-H Localized Colon Cancer: PREMICES Study. Pembrolizumab Injection [Keytruda], Watch-and-wait approach, Surgery - Colon Cancer | Phase 2 | Not yet recruiting | GERCOR - Multidisciplinary Oncology Cooperative Group | 60 | 2025-09-01 | 2025-06-13 |
| A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors. NDI-219216 - Advanced Solid Tumors Cancer, MSI-H Cancer | Phase 1 / Phase 2 | Recruiting | Nimbus Wadjet, Inc. | 134 | 2025-03-31 | 2026-05-06 |
| Routine Shallow-coverage Whole Genome Sequencing Testing of Liquid-based Cervical Smears for the Early Diagnosis of Ovarian Cancer High Grade Serous Ovarian Cancer, Cervical Cancer Screening | Recruiting | Institut Claudius Regaud | 50 | 2025-01-05 | 2026-09-16 | |
| First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or Metastatic Solid Tumors, and Molecularly Defined Cancers ATX-559 - Advanced Solid Tumors, Breast Cancer Recurrent | Phase 1 | Terminated | Accent Therapeutics | 17 | 2024-10-11 | 2026-02-24 |
| Translational Study of MSS, TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma Endometrial Neoplasms, TP53 Gene Mutation | Unknown | Peking Union Medical College Hospital | 110 | 2024-09-01 | 2024-07-26 | |
| A Study of Sovilnesib in Subjects With Ovarian Cancer Sovilnesib - High Grade Serous Adenocarcinoma of Ovary, Fallopian Tube Cancer | Phase 1 | Recruiting | Volastra Therapeutics, Inc. | 150 | 2024-04-04 | 2026-10-13 |
| A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors VVD-133214, Pembrolizumab, Bevacizumab - Advanced Solid Tumors, Colorectal Cancer | Phase 1 | Recruiting | Vividion Therapeutics, Inc. | 280 | 2024-01-25 | 2026-11-12 |
| Analyzing the Urine During BCG Instillation in Bladder Cancer Patients for Disease Followup urine sample collection - Bladder Cancer | Unknown | Changhai Hospital | 100 | 2023-12-01 | 2023-12-01 | |
| A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer VLS-1488 - Advanced Solid Tumor, High Grade Serous Adenocarcinoma of Ovary | Phase 1 / Phase 2 | Recruiting | Volastra Therapeutics, Inc. | 200 | 2023-10-18 | 2025-11-04 |
| MMR/MSI Phenotypes in Prediction of Tumor Vaccine Benefit for Gliomas DC vaccine - Glioma | Unknown | Huashan Hospital | 360 | 2023-09-01 | 2023-09-21 | |
| Liquid Biopsy Biomarkers for Endoscopic Surveillance in Lynch Syndrome Study procedures - Lynch Syndrome, Hereditary Nonpolyposis Colorectal Cancer | Completed | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 109 | 2023-06-20 | 2026-09-24 | |
| Bladder Cancer and Neoadjuvant Chemotherapy Efficiency Before Cystectomy neoadjuvant chemotherapy with cisplatine - Bladder Cancer, Genomic Instability | Unknown | University Hospital, Rouen | 707 | 2023-04-01 | 2024-03-06 | |
| Application of Chromosomal Instability in Early Diagnosis of Biliary Tract Carcinoma The extracted DNA from bile samples will be analyzed by BileCAD to determine the level of CIN. - Biliary Tract Carcinoma | Unknown | Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University | 300 | 2023-03-30 | 2023-12-18 | |
| Non-Invasive Diagnosis of Endometrial Cancer cervical cytology during surgery. - Endometrial Cancer | Not applicable | Unknown | Assistance Publique - Hôpitaux de Paris | 100 | 2023-03-03 | 2024-02-22 |
| Epidemiology and Overtime Genomic Evolution of Klebsiella Pneumoniae and Enterobacter Cloacae Complex (ECC) in Stools of ICU's Patients Longitudinal, Genomic Stability | Recruiting | University Hospital, Caen | 20 | 2023-01-20 | 2026-08-04 | |
| A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors STAR0602, Irinotecan (Camptosar), Docetaxel (Taxotere) - Advanced Solid Tumors, Genital Neoplasm, Female | Phase 1 / Phase 2 | Recruiting | Marengo Therapeutics, Inc. | 366 | 2023-01-04 | 2026-08-11 |
| Effect of a Fruit- and Chaya-Based Diet on Genomic Instability and Biochemical Markers in Women With Breast Cancer Receiving Chemotherapy Fruits and chaya infusion, Conventional diet - Breast Cancer | Not applicable | Completed | Anahuac Mayab University | 13 | 2022-08-01 | 2025-06-11 |
| Dynamics of MSI and Genomic Profile of Colorectal Cancer In the Course of Immune Checkpoint Inhibitor Therapy Colorectal Cancer, Colorectal Cancer Metastatic | Completed | OncoAtlas LLC | 30 | 2022-06-01 | 2025-06-27 | |
| Neoadjuvant Prolgolimab Monotherapy in Locally Advanced MMR-deficient Colorectal Cancer Prolgolimab - Colorectal Cancer | Phase 2 | Completed | Blokhin's Russian Cancer Research Center | 30 | 2022-03-31 | 2026-04-27 |
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Microsatellite Instability (49) · Colorectal Neoplasms (24) · Stomach Neoplasms (10) · Chromosomal Instability (9) · Endometrial Neoplasms (9) · Turcot syndrome (7) · Uterine Cervical Neoplasms (7) · Carcinoma, Merkel Cell (6) · Carcinoma, Renal Cell (6) · Colonic Neoplasms (6) · Melanoma (6) · Small Cell Lung Carcinoma (6) · Carcinoma, Hepatocellular (5) · Colorectal Neoplasms, Hereditary Nonpolyposis (5)
Pathologic Processes (66) · Pathological Conditions, Signs and Symptoms (66) · Neoplasms (51) · Neoplasms by Site (49) · Digestive System Diseases (37) · Digestive System Neoplasms (37) · Gastrointestinal Diseases (37) · Gastrointestinal Neoplasms (36) · Intestinal Diseases (32) · Intestinal Neoplasms (32) · Colonic Diseases (31) · Rectal Diseases (26) · Urogenital Diseases (21) · Female Urogenital Diseases (20)
pembrolizumab (8) · Nivolumab (6) · atezolizumab (3) · durvalumab (3) · Cyclophosphamide (2) · Docetaxel (2) · Injections (2) · Ipilimumab (2) · Neoadjuvant Therapy (2) · Surgical Procedures, Operative (2) · avelumab (2) · fludarabine (2) · ALT-803 (1) · Ado-Trastuzumab Emtansine (1) · Bevacizumab (1)
Lei Li (4) · GERCOR - Multidisciplinary Oncology Cooperative Group (3) · Assistance Publique - Hôpitaux de Paris (2) · Fate Therapeutics (2) · National Taiwan University Hospital (2) · Radboud University Medical Center (2) · The First Affiliated Hospital with Nanjing Medical University (2) · Volastra Therapeutics, Inc. (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Accent Therapeutics (1) · Affiliated Hospital of Qinghai University (1) · Anahuac Mayab University (1) · Apollomics (Australia) Pty. Ltd. (1) · Blokhin's Russian Cancer Research Center (1) · Changhai Hospital (1)
United States (18) · France (14) · China (13) · Italy (5) · Netherlands (4) · United Kingdom (4) · Australia (3) · Canada (3) · Spain (3) · Russia (2) · Taiwan (2) · Belgium (1) · Denmark (1) · India (1) · Ireland (1)
Lei Li, M.D. (3) · Jin-Tung Liang, M.D., Ph.D. (2) · Anita Scheuber, MD, PhD (1) · Bernard Hirschel (1) · Charles Swanton (1) · David Tougeron, MD PHD (1) · Dung Le, MD (1) · Eav Lim, DO (1) · Filippo Pietrantonio, MD (1)
PMID 10517999, PMID 12213959, PMID 15306730, PMID 16765182, PMID 16973674, PMID 18023252, PMID 18540930, PMID 20379742, PMID 21944903, PMID 23410167, PMID 23525098, PMID 23652021, PMID 24184488, PMID 25386035, PMID 25446328, PMID 26718401, PMID 29357859, PMID 30943124, PMID 31682550, PMID 31980466, PMID 32079623, PMID 32359091, PMID 32919526, PMID 33109741, PMID 33148693, PMID 33836153, PMID 33992635, PMID 34990208, PMID 35114169, PMID 35361487, PMID 35522273, PMID 35588692, PMID 35680043, PMID 35777186, PMID 35791694, PMID 35835611, PMID 35969830, PMID 36748723, PMID 37269904, PMID 39374480, PMID 39594133, PMID 39637944, PMID 39979665, PMID 40121391, PMID 40340830, PMID 40389373, PMID 40885102, PMID 40907210, PMID 41370727, PMID 41920388
2023 (2), 2015 (1), 2016 (1), 2018 (1), P30CA014089 (1), P30CA015704 (1), P50CA062924 (1)