6 completed, 5 recruiting, 3 unknown, 1 terminated. 3 Not applicable, 3 Phase 1, 3 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Completed 2, Unknown 1 |
| Phase 1 | 3 | Completed 1, Recruiting 1, Unknown 1 |
| Phase 2 | 3 | Completed 1, Recruiting 1, Unknown 1 |
| Phase 3 | 1 | Recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow Fuchs Dystrophy: new trials by email Literature Review of Fuchs Dystrophy trials Research Report on Fuchs Dystrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction 150K cells, 500K cells, Placebo - Corneal Edema, Fuchs | Phase 2 | Recruiting | Emmecell | 121 | 2026-10-01 | 2026-10-09 |
| FECD-TRACE: Fuchs' Endothelial Corneal Dystrophy TRAjectory and Correlation With Genotype in the United Kingdom Clinical phenotyping, CTG18.1 Expansion Status Genotyping - Fuchs Dystrophy, Fuchs' Endothelial Dystrophy | Recruiting | University College, London | 500 | 2024-02-01 | 2025-03-18 | |
| The Evaluation of Balanced Salt Solution During Cataract Surgery BSS Plus, BSS - Fuchs Dystrophy, Cataract | Phase 4 | Completed | Adam Fedyk, MD, FACS | 26 | 2023-04-17 | 2025-07-03 |
| Descemet Endothelial Thickness Comparison Trial II Ripasudil, Placebo - Fuchs, Fuchs Dystrophy | Phase 3 | Recruiting | Stanford University | 60 | 2023-01-23 | 2026-08-17 |
| Study to Assess Safety and Tolerability of Multiple Doses of EO2002 EO2002, Ripasudil - Corneal Edema, Corneal Endothelial Dystrophy | Phase 1 | Recruiting | Asociación para Evitar la Ceguera en México | 12 | 2022-11-08 | 2025-12-08 |
| Study of Safety and Tolerability of EO2002 in the Treatment of Corneal Edema EO2002, EO2002 low dose, EO2002 mid dose - Corneal Edema, Corneal Endothelial Dysfunction | Phase 1 | Completed | Emmecell | 42 | 2021-06-22 | 2025-03-05 |
| TTHX1114(NM141) in Combination With DWEK/DSO TTHX1114(NM141) - Fuchs' Endothelial Dystrophy, Fuchs Dystrophy | Phase 2 | Completed | Trefoil Therapeutics, Inc. | 49 | 2021-02-01 | 2023-11-07 |
| Descemet Membrane Endothelial Keratoplasty vs. Descemet's Stripping With Endothelial Keratoplasty vs. Descemet Stripping Only Optical Coherence Tomography - Cystoid Macular Edema, Fuchs Dystrophy | Terminated | Wake Forest University Health Sciences | 4 | 2020-11-21 | 2023-01-13 | |
| OCT in Fuchs' Dystrophy Fuchs Dystrophy, Pseudophakic Bullous Keratopathy | Recruiting | Oregon Health and Science University | 60 | 2020-06-26 | 2025-09-09 | |
| Femtolaser Assisted Keratoplasty Versus Conventional Keratoplasty Femtosecond Laser, Trephine blade - Keratoconus, Fuchs Dystrophy | Not applicable | Unknown | University of Southampton | 30 | 2019-02-01 | 2020-12-22 |
| The ADVISE Study: Advanced Visualization In Corneal Surgery Evaluation intraoperative optical coherence tomography (iOCT) - Fuchs Dystrophy, Endothelial Corneal Dystrophy | Not applicable | Completed | UMC Utrecht | 65 | 2018-11-13 | 2022-11-15 |
| Ripasudil 0.4% Eye Drops in Fuchs Endothelial Corneal Dystrophy Ripasudil eye drops, Optive eye drops, Descemetorhexis - Fuchs' Endothelial Dystrophy, Fuchs Dystrophy | Phase 2 | Unknown | University of Erlangen-Nürnberg Medical School | 21 | 2018-06-05 | 2018-07-12 |
| Association Between Fuchs' Endothelial Corneal Dystrophy Severity and Estrogen Exposure This is an observational study. There is no therapeutic intervention. - Fuchs Dystrophy | Completed | State University of New York at Buffalo | 43 | 2018-01-17 | 2024-10-01 | |
| Phase 1 Study to Evaluate the Safety and Tolerability of EO1404 in the Treatment of Corneal Edema EO1404, Endothelial brushing or Descemet stripping - Corneal Edema, Fuchs Dystrophy | Phase 1 | Unknown | Valeria Sanchez-Huerta | 35 | 2016-05-04 | 2019-12-10 |
| A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema Corneal transplantation - Fuchs Dystrophy, Corneal Edema | Not applicable | Completed | Mayo Clinic | 29 | 2005-06-01 | 2010-01-15 |
Fuchs' Endothelial Dystrophy (15) · Corneal Dystrophy, Posterior Polymorphous, 1 (5) · Corneal Edema (5) · Corneal Endothelial Cell Loss (2) · Corneal endothelial dystrophy type 2 (2) · Cataract (1) · Corneal Diseases (1) · Corneal Dystrophies, Hereditary (1) · Corneal Endothelial Dystrophy 1 (1) · Keratoconus (1) · Macular Edema (1) · Vision Disorders (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (15) · Eye Diseases (15) · Eye Diseases, Hereditary (15) · Genetic Diseases, Inborn (15) · Corneal Diseases (14) · Corneal Dystrophies, Hereditary (14) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Eye Manifestations (2) · Pathologic Processes (2) · Postoperative Complications (2) · Lens Diseases (1) · Macular Degeneration (1) · Nervous System Diseases (1) · Neurologic Manifestations (1)
K-115 (2) · Corneal Transplantation (1) · Tomography, Optical Coherence (1) · glutathione-bicarbonate-Ringer solution (1)
Emmecell (2) · Adam Fedyk, MD, FACS (1) · Asociación para Evitar la Ceguera en México (1) · Mayo Clinic (1) · Oregon Health and Science University (1) · Stanford University (1) · State University of New York at Buffalo (1) · Trefoil Therapeutics, Inc. (1) · UMC Utrecht (1) · University College, London (1) · University of Erlangen-Nürnberg Medical School (1) · University of Southampton (1) · Valeria Sanchez-Huerta (1) · Wake Forest University Health Sciences (1)
United States (9) · Mexico (2) · United Kingdom (2) · Belgium (1) · Germany (1) · Netherlands (1)
Alice Davidson, PhD (1) · Jennifer Rose-Nussbaumer, MD (1) · Matthew Giegengack (1) · Noelia Kunzevitzky (1) · Noelia Kunzevitzky, PhD (1) · Parwez Hossain, B ChB, PhD (1) · Sagita Patel (1) · Thomas Tremblay (1) · Valeria Sanchez Huerta, MD (1) · Valeria Sanchez-Huerta, MD (1) · Winston Chamberlain, MD, PhD (1)
PMID 17996211, PMID 19298950, PMID 22357383, PMID 25015214, PMID 35184123, PMID 36730371, PMID 38983542, PMID 39353677, PMID 39509248, PMID 40374208, PMID 40789362
2017 (1), R01EY029023 (1)