8 not yet recruiting, 3 recruiting, 2 completed, 1 active not recruiting. 9 Not applicable, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Not yet recruiting 5, Recruiting 2, Active not recruiting 1, Completed 1 |
| Phase 1 | 1 | Not yet recruiting 1 |
| Phase 2 | 1 | Not yet recruiting 1 |
Follow Frailty in Older Adults: new trials by email Literature Review of Frailty in Older Adults trials Research Report on Frailty in Older Adults
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ENRICH Study: A Mixed-methods Feasibility Study of a Nurse-led Model of Care for Social Frailty in Philippine Primary Care Group activities (i.e., low impact exercise), peer counseling, volunteering, Social Frailty Care Bundle (SFCB) - Frailty, Frailty in Older Adults | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 30 | 2027-01-01 | 2026-10-06 |
| Safety and Tolerability Study of Mesenchymal Stem Cells, HeXell-2020, in Elderly Subjects With Mild to Moderate Frailty Syndrome HeXell-2020 - Frailty in Older Adults | Phase 1 | Not yet recruiting | Hexun Biosciences Co., LTD. | 12 | 2026-12-31 | 2026-09-25 |
| Effects of a Community-based Multicomponent Physical Exercise Program on Physical Function, Frailty, and Sarcopenia in Older Adults From the Municipality of Santoña: a Quasi-experimental Study. Multicomponent Exercise Program (Vivifrail-based) - Frailty/Sarcopenia, Frailty in Older Adults | Not applicable | Not yet recruiting | Universidad de Granada | 300 | 2026-10-01 | 2026-07-30 |
| A Pilot Study to Explore the Feasibility of Navigator and Coach Support for Community Participation by Older People Navigation support, Coaching support - Frailty, Social Isolation in Older Adults | Not applicable | Not yet recruiting | Bastiaan Van Grootven | 45 | 2026-10-01 | 2026-09-23 |
| Multi-Component Delirium Prevention Bundle in Older Cardiac Intensive Care Unit Patients Multicomponent Delirium Prevention Bundle, Control Group - Delirium in Old Age, Delirium in the Intensive Care Unit | Not applicable | Active not recruiting | Tel Aviv Medical Center | 200 | 2026-06-02 | 2026-08-21 |
| Prevalence of Anticholinergics in Geriatric Patients With Acute Functional Deterioration No intervention as the study is observational - Frailty in Older Adults, Functional Decline | Not yet recruiting | Aalborg University Hospital | 100 | 2025-09-01 | 2025-09-10 | |
| Safety and Efficacy of Isomyosamine in Reducing Inflammation and Treating Muscle Loss in Older Adults After Hip or Thigh Bone Fractures Isomyosamine 250mg, Placebo 250 mg - Sarcopenia in Elderly, Frailty | Phase 2 | Not yet recruiting | TNF Pharmaceuticals, Inc. | 60 | 2025-05-01 | 2025-04-24 |
| The Effects of Intelligent Intervention Programs on Hospitalized Elderly People With Frailty. Intelligent intervention programs - Frailty in Older Adults | Not applicable | Not yet recruiting | National Taipei University of Nursing and Health Sciences | 156 | 2025-04-15 | 2025-04-03 |
| Comparison of Preoperative Frailty Assessment Tools Assessment of frailty using multiple tools - Frailty, Frailty in Older Adults | Recruiting | Universitätsklinikum Hamburg-Eppendorf | 584 | 2025-04-15 | 2026-07-22 | |
| Chair-bound Exergaming in Pre-frail/ Frail Older Adults in Nursing Home Exergaming - Frailty in Older Adults | Not applicable | Recruiting | Hong Kong Metropolitan University | 30 | 2025-04-07 | 2025-05-14 |
| Allogeneic Human Mesenchymal Stem Cell Infusion for Frailty Patient Daewoong Biologics Indonesia Umbilical Cord-derived Mesenchymal Stem Cell (DBI UC-MSC) - Frailty in Older Adults | Not applicable | Completed | Daewoong Group Indonesia | 10 | 2025-03-24 | 2026-03-04 |
| A Biopsychosocial Approach to Improving Multidimensional Frailty Status in Community-Dwelling Older Adults Exercise, Psychosocial, Nutritional - Frailty in Older Adults | Not applicable | Not yet recruiting | Hong Kong Baptist University | 308 | 2025-01-01 | 2024-12-19 |
| Optimizing INtrinsic Capacity for Functional INdependence and to Impede FrailTY in Older Adults: Adaptation of the WHO-ICOPE for Healthy Ageing in Singapore INFINITY-ICOPE programme - Frailty in Older Adults, Intrinsic Capacity | Not applicable | Recruiting | Sengkang General Hospital | 600 | 2023-07-17 | 2026-04-17 |
| Postoperative Frailty Trajectories and One-Year Mortality in Older Surgical Patients Frailty in Older Adults, All Cause Mortality | Completed | Chinese PLA General Hospital | 4417 | 2020-04-01 | 2026-01-09 |
Frailty (9) · Sarcopenia (3) · Acute Coronary Syndrome (1) · Anticholinergic Syndrome (1) · Confusion (1) · Delirium (1) · Femoral Fractures (1) · Hip Fractures (1)
Pathologic Processes (9) · Pathological Conditions, Signs and Symptoms (9) · Nervous System Diseases (4) · Neurologic Manifestations (4) · Signs and Symptoms (4) · Atrophy (3) · Muscular Atrophy (3) · Neuromuscular Manifestations (3) · Pathological Conditions, Anatomical (3) · Cardiovascular Diseases (1) · Chemically-Induced Disorders (1) · Drug-Related Side Effects and Adverse Reactions (1) · Fractures, Bone (1) · Heart Diseases (1) · Hip Injuries (1)
Control Groups (1) · Exercise (1) · Exergaming (1)
Aalborg University Hospital (1) · Bastiaan Van Grootven (1) · Chinese PLA General Hospital (1) · Daewoong Group Indonesia (1) · Hexun Biosciences Co., LTD. (1) · Hong Kong Baptist University (1) · Hong Kong Metropolitan University (1) · National Taipei University of Nursing and Health Sciences (1) · Sengkang General Hospital (1) · TNF Pharmaceuticals, Inc. (1) · Tel Aviv Medical Center (1) · The Hong Kong Polytechnic University (1) · Universidad de Granada (1) · Universitätsklinikum Hamburg-Eppendorf (1)
China (1) · Denmark (1) · Germany (1) · Hong Kong (1) · Indonesia (1) · Israel (1) · Philippines (1) · Singapore (1) · Spain (1) · Switzerland (1) · Taiwan (1)
Bastiaan Van Grootven (1) · Dr. Cynthia Olotu, MD (1) · Jed G Montayre, PhD, RN (1) · Keren Lee Rozenfeld, MD (1) · Laura Bee Gek Tay (1) · Yishay Szekely, MD (1) · dr. Jonny Sp.PD-KEGH, MM, M.Kes, Post-doc (1)
PMID 11253156, PMID 15817019, PMID 16155782, PMID 2748771, PMID 28848332, PMID 32063457, PMID 32648471, PMID 32915990, PMID 33051948, PMID 33858827, PMID 34878637, PMID 35820405, PMID 35851589, PMID 38014479, PMID 38156422, PMID 40665217