14 completed, 1 not yet recruiting, 1 terminated. 9 Phase 3, 2 Phase 2, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Completed 8, Not yet recruiting 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Dupuytren's Contracture: new trials by email Literature Review of Dupuytren's Contracture trials Research Report on Dupuytren's Contracture
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DEPART Study at Yale Radiation Therapy - Dupuytren's Contracture | Phase 3 | Not yet recruiting | Yale University | 158 | 2026-11-01 | 2026-10-13 |
| Real-World Data Study to Understand Participant Treatment Outcomes for Dupuytren's Contracture Dupuytren's Contracture | Terminated | Endo USA Inc., a Keenova Therapeutics Company | 130 | 2023-06-14 | 2024-04-16 | |
| Safety and Efficacy of Two Concurrent Injections of AA4500 in Adult Subjects With Multiple Dupuytren's Contractures XIAFLEX / XIAPEX - Dupuytren's Contracture | Phase 3 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 715 | 2012-09-01 | 2017-10-05 |
| CORRECT: COmmunity RegistRy Study Evaluating Dupuytren's Contracture Treatment Dupuytren's Contracture | Completed | Endo USA Inc., a Keenova Therapeutics Company | 162 | 2012-09-01 | 2015-06-16 | |
| Collagenase Option for Reduction of Dupuytren's Contracture in Japan Collagenase Clostridium Histolyticum - Dupuytren's Contracture | Phase 3 | Completed | Asahi Kasei Therapeutics Corporation | 104 | 2012-05-01 | 2017-03-21 |
| Post Approval Commitment Study Xiapex, surgery - Dupuytren's Contracture | Completed | Endo USA Inc., a Keenova Therapeutics Company | 305 | 2012-03-01 | 2017-10-26 | |
| Administration of Two Injections for Multiple Dupuytren's Contractures AA4500 collagenase clostridium histolyticum - Dupuytren's Contracture | Phase 3 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 60 | 2011-09-01 | 2017-10-05 |
| Treatment Of Dupuytren's Contracture With Collagenase Clostridium Histolyticum Injection (Xiapex) Xiapex - Dupuytren's Contracture | Phase 3 | Completed | Pfizer | 254 | 2010-12-01 | 2014-03-17 |
| Efficacy and Safety of Xiaflex Injection for Treatment of Dupuytren's Contracture of the Thumb Injectable clostridial collagenase - Dupuytren's Contracture | Phase 4 | Completed | Indiana Hand to Shoulder Center | 7 | 2010-12-01 | 2015-04-30 |
| Effects of Steroid Injection With Percutaneous Needle Aponeurotomy in Dupuytren's Contracture Triamcinolone Acetonide - Dupuytren's Contracture | Phase 3 | Completed | Sunnybrook Health Sciences Centre | 51 | 2007-11-01 | 2013-12-13 |
| A Pharmacokinetic Study of AA4500 (XIAFLEX™, Proposed Name) in Subjects With Dupuytren's Contracture collagenase clostridium histolyticum - Dupuytren's Contracture | Phase 1 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 16 | 2007-09-01 | 2017-10-05 |
| Evaluation of the Efficiency of Autologous Platelet Gel (Platelet Rich Fibrin) Obtained From Own Patients' Blood Versus Vaselitulle in Dupuytren's Disease Postoperative Wound Healing Autologous platelets gel, Vaselitulle - Dupuytren's Contracture | Phase 2 / Phase 3 | Completed | Centre Hospitalier Universitaire de Nice | 80 | 2007-08-01 | 2012-03-20 |
| AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Dupuytren's Contracture collagenase clostridium histolyticum, Placebo - Dupuytren's Contracture | Phase 3 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 308 | 2007-08-01 | 2017-12-02 |
| Health-Related Quality of Life in Patients With Dupuytren's Disease Dupuytren's Contracture | Completed | Hamilton Health Sciences Corporation | 51 | 2007-05-01 | 2011-07-28 | |
| Phase II Randomized Study of Collagenase in Patients With Residual Type Dupuytren's Disease collagenase - Dupuytren's Contracture | Phase 2 | Completed | State University of New York | 36 | 1995-08-01 | 2015-03-25 |
| Phase III Randomized Study of Collagenase in Patients With Residual Stage Dupuytren's Disease collagenase - Dupuytren's Contracture | Phase 3 | Completed | State University of New York | 72 | 2015-03-25 |
Dupuytren Contracture (16) · Arthritis (2) · Connective Tissue Diseases (2) · Contracture (2) · Rare Diseases (2)
Fibroma (16) · Muscular Diseases (16) · Musculoskeletal Diseases (16) · Neoplasms (16) · Neoplasms by Histologic Type (16) · Neoplasms, Connective Tissue (16) · Neoplasms, Connective and Soft Tissue (16) · Neoplasms, Fibrous Tissue (16) · Skin and Connective Tissue Diseases (16) · Connective Tissue Diseases (14) · Contracture (14) · Joint Diseases (4) · Disease Attributes (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2)
Microbial Collagenase (6) · xiapex (5) · Collagenases (2) · Radiotherapy (1) · Surgical Procedures, Operative (1) · Triamcinolone Acetonide (1)
Endo USA Inc., a Keenova Therapeutics Company (7) · State University of New York (2) · Asahi Kasei Therapeutics Corporation (1) · Centre Hospitalier Universitaire de Nice (1) · Hamilton Health Sciences Corporation (1) · Indiana Hand to Shoulder Center (1) · Pfizer (1) · Sunnybrook Health Sciences Centre (1) · Yale University (1)
United States (9) · Canada (2) · France (2) · Spain (2) · Australia (1) · Denmark (1) · Germany (1) · Hungary (1) · Italy (1) · Japan (1) · Norway (1) · Sweden (1) · United Kingdom (1)
Lawrence C. Hurst (2) · Veronica Urdaneta, MD (2) · Veronica Urdaneta, MD, MPPH (2) · Achilleas Thoma, MD MSC (1) · Bruce McGibbon, MD (1) · Frank D Buono, PhD (1) · Paul A. Binhammer, MD,MSc (1) · Urdaneta Veronica, MD (1) · Veronica Urdaneta (1)
PMID 19726771, PMID 21967070, PMID 23190833, PMID 24470559, PMID 24569424, PMID 27313184