21 completed, 8 terminated, 2 unknown. 18 Phase 3, 8 Phase 2, 4 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 18 | Completed 10, Terminated 6, Unknown 2 |
| Phase 2 | 8 | Completed 6, Terminated 2 |
| Phase 4 | 4 | Completed 4 |
Follow Diabetes Mellitus, Lipoatrophic: new trials by email Literature Review of Diabetes Mellitus, Lipoatrophic trials Research Report on Diabetes Mellitus, Lipoatrophic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Extension Study of Empagliflozin in Patients With Refractory Diabetes Mellitus With Insulin Resistance ( EMPIRE-02 ) Empagliflozin Tablets - Insulin Resistance - Type A, Insulin Resistance - Type B | Phase 3 | Unknown | Kobe University | 8 | 2020-02-01 | 2021-06-03 |
| A Study of Empagliflozin in Patients With Refractory Diabetes Mellitus With Insulin Resistance Empagliflozin Tablets - Insulin Resistance - Type A, Insulin Resistance - Type B | Phase 3 | Unknown | Kobe University | 8 | 2019-09-01 | 2021-03-03 |
| Study of AKCEA-ANGPTL3-LRx (ISIS 703802) in Participants With Familial Partial Lipodystrophy (FPL) AKCEA-ANGPTL3-LRx - Familial Partial Lipodystrophy | Phase 2 | Completed | Akcea Therapeutics | 4 | 2018-06-15 | 2021-02-16 |
| Efficacy and Safety of Pioglitazone in Treating Subjects With Vascular Complications Associated With Type 2 Diabetes Mellitus. Pioglitazone and Metformin, Glibenclamide and Metformin - Diabetes Mellitus | Phase 4 | Completed | Takeda | 39 | 2009-03-01 | 2011-07-12 |
| Efficacy of Pioglitazone and Insulin in Treating Subjects With Type 2 Diabetes Mellitus and Renal Failure. Pioglitazone and insulin, Insulin - Diabetes Mellitus | Phase 2 | Completed | Takeda | 40 | 2008-08-01 | 2010-09-01 |
| Efficacy and Safety of TAK-379 in Adult Subjects With Type 2 Diabetes Mellitus TAK-379, Pioglitazone, Placebo - Diabetes Mellitus | Phase 2 | Terminated | Takeda | 323 | 2008-07-01 | 2016-06-22 |
| Efficacy of Pioglitazone and Metformin on Cardiovascular Risk in Subjects With Insulin-Treated Type 2 Diabetes Mellitus. Pioglitazone and insulin, Pioglitazone and metformin and insulin, Metformin and insulin - Diabetes Mellitus | Phase 4 | Completed | Takeda | 121 | 2008-05-01 | 2010-08-18 |
| Efficacy and Safety of Pioglitazone and Metformin Combination Therapy in Treating Type 2 Diabetes Mellitus. Pioglitazone and metformin, Pioglitazone, Metformin - Diabetes Mellitus | Phase 3 | Completed | Takeda | 600 | 2007-06-01 | 2011-07-29 |
| Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus SYR-472, Placebo - Diabetes Mellitus | Phase 2 | Completed | Takeda | 369 | 2007-05-01 | 2016-06-22 |
| Efficacy of Pioglitazone/Metformin Combination Therapy in Subjects With Type 2 Diabetes Mellitus and Dyslipidemia. Pioglitazone and Metformin, Glimepiride and Metformin - Diabetes Mellitus, Dyslipidemias | Phase 3 | Completed | Takeda | 305 | 2007-04-01 | 2010-10-06 |
| Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus SYR-472, Placebo, Sitagliptin - Diabetes Mellitus | Phase 2 | Completed | Takeda | 386 | 2007-03-01 | 2016-06-22 |
| Efficacy of Alogliptin and Pioglitazone in Subjects With Type 2 Diabetes Mellitus Alogliptin, Pioglitazone, Metformin - Diabetes Mellitus | Phase 3 | Completed | Takeda | 803 | 2007-01-01 | 2013-04-04 |
| Efficacy and Safety Study of Pioglitazone Combined With Metformin on Metabolic Syndrome in Subjects With Type 2 Diabetes Pioglitazone and Metformin, Metformin - Diabetes Mellitus | Phase 3 | Completed | Takeda | 418 | 2007-01-01 | 2010-07-05 |
| Efficacy of Pioglitazone and Glimepiride Combination Therapy in Treating Subjects With Type 2 Diabetes Mellitus. Pioglitazone and Glimepiride, Glimepiride - Diabetes Mellitus | Phase 3 | Completed | Takeda | 91 | 2006-12-01 | 2010-07-05 |
| Efficacy and Safety Study of SYR-619 in Treating Subjects With Type 2 Diabetes Mellitus SYR-619, Placebo, Alogliptin - Diabetes Mellitus | Phase 2 | Terminated | Takeda | 82 | 2006-11-01 | 2012-05-21 |
| Efficacy of Alogliptin With Pioglitazone (Actos®) in Subjects With Type 2 Diabetes Mellitus Alogliptin, Pioglitazone, Placebo - Diabetes Mellitus | Phase 3 | Completed | Takeda | 655 | 2006-11-01 | 2013-03-27 |
| Efficacy of Pioglitazone and Fortamet Combination Therapy in Subjects With Type 2 Diabetes Pioglitazone and metformin, Metformin - Diabetes Mellitus | Phase 4 | Completed | Takeda | 312 | 2005-07-01 | 2010-07-05 |
| Efficacy and Safety Study of TAK-559 in Treating Subjects With Type 2 Diabetes Mellitus TAK-559, Placebo - Diabetes Mellitus | Phase 3 | Terminated | Takeda | 8 | 2004-11-01 | 2012-11-12 |
| Safety and Efficacy of TAK-559 in Combination With Metformin in Patients With Type 2 Diabetes Mellitus. TAK-559 and metformin, Metformin - Diabetes Mellitus | Phase 3 | Terminated | Takeda | 15 | 2004-11-01 | 2012-02-28 |
| Efficacy and Safety of Pioglitazone and Azilsartan in Treating Subjects With Type 2 Diabetes Mellitus Pioglitazone and azilsartan, Pioglitazone - Diabetes Mellitus | Phase 2 | Completed | Takeda | 704 | 2004-07-01 | 2012-02-28 |
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Diabetes Mellitus (30) · Dyslipidemias (28) · Diabetes Mellitus, Type 2 (27) · Glucose Metabolism Disorders (27) · Diabetes Mellitus, Insulin-Resistant, with Acanthosis Nigricans (2) · Hyperglycemia (2) · Insulin Resistance (2) · Lipodystrophy (2) · Metabolic Syndrome (2) · Atherosclerosis (1) · Hyperlipidemias (1) · Hypertriglyceridemia (1) · Lipid Metabolism Disorders (1) · Lipodystrophy, Familial Partial (1)
Endocrine System Diseases (31) · Metabolic Diseases (31) · Nutritional and Metabolic Diseases (31) · Lipid Metabolism Disorders (28) · Diabetes Mellitus, Type 2 (4) · Glucose Metabolism Disorders (4) · Hyperinsulinism (2) · Skin Diseases (2) · Skin Diseases, Metabolic (2) · Skin and Connective Tissue Diseases (2) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Cardiovascular Diseases (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Diabetes Mellitus (1)
Pioglitazone (18) · Metformin (9) · (E)-4-(4-((5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy)benzyloxyimino)-4-phenylbutyric acid (6) · Glyburide (4) · glimepiride (4) · Insulin (3) · alogliptin (3) · empagliflozin (2) · trelagliptin (2) · Leptin (1) · Sitagliptin Phosphate (1) · Sulfonylurea Compounds (1) · azilsartan (1) · metreleptin (1)
Takeda (27) · Kobe University (2) · Akcea Therapeutics (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1)
United States (12) · Chile (5) · Germany (4) · Mexico (4) · Argentina (3) · Puerto Rico (3) · Guatemala (2) · Hungary (2) · Japan (2) · Latvia (2) · Lithuania (2) · Romania (2) · Russia (2) · Slovakia (2) · Ukraine (2)
Wataru Ogawa (2) · Phillip Gorden, M.D. (1)
PMID 19744248, PMID 17101640, PMID 17327456, PMID 18378631, PMID 18413496, PMID 18469202, PMID 18672190, PMID 19228869, PMID 19727665, PMID 20557330, PMID 20724648, PMID 21122063, PMID 21211686, PMID 21457065, PMID 21733058, PMID 22068254, PMID 22965160, PMID 24926953, PMID 25070319, PMID 25734254, PMID 26589105, PMID 26900642, PMID 28324110, PMID 31194872, PMID 34223895, PMID 34677608, PMID 37595266, PMID 38216831