15 completed, 2 terminated, 2 unknown. 7 Phase 2, 5 Not applicable, 3 Phase 1, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 7 |
| Not applicable | 5 | Completed 3, Terminated 1, Unknown 1 |
| Phase 1 | 3 | Completed 2, Terminated 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
| Phase 4 | 1 | Completed 1 |
Follow Leptin: new trials by email Literature Review of Leptin trials Research Report on Leptin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Salivary and Serum Leptin Levels in Oral Lichen Planus Patients: A Case-control Study. Leptin - Oral Lichen Planus, Leptin Levels | Completed | Cairo University | 78 | 2023-12-30 | 2025-03-30 | |
| Nutrition and Growth in Very Preterm Infants Oral nutritional intake - Premature, Growth | Completed | Children's Hospital of Fudan University | 180 | 2019-08-01 | 2023-02-08 | |
| Serotonin, Leptin and Adiponectin Level in Patients With Postpartum Depression: Controlled Study leptin, serotonin and adiponectin level, leptin,serotonin, adiponectin level - Postpartum Depression | Completed | Zeynep Kamil Maternity and Pediatric Research and Training Hospital | 400 | 2016-02-01 | 2022-03-15 | |
| Hypercortisolism and Epicardial Adipose Tissue Blood samples for measuring adiponectin, leptin and omentin plasma, MRI at 3 Tesla - Hypercortisolism | Not applicable | Completed | Assistance Publique Hopitaux De Marseille | 43 | 2014-12-08 | 2023-05-26 |
| Mother-caregivers of Children With Duchenne Muscular Dystrophy sleep parameters, Hormonal profile, Inflammatory profile - Other Diseases or Conditions | Not applicable | Completed | Monica Levy Andersen | 60 | 2013-08-01 | 2016-02-03 |
| Effects of Metreleptin in Type 1 Diabetes Mellitus Leptin - Type 1 Diabetes | Phase 1 | Terminated | University of Texas Southwestern Medical Center | 8 | 2010-09-01 | 2019-08-28 |
| Leptin in the Maintenance of Reduced Body Weight Leptin, Placebo - Obesity | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 24 | 2008-07-01 | 2017-04-07 |
| Trial of Leptin Administration After Roux-en-Y Gastric Bypass Leptin, Placebo - Overweight | Phase 1 / Phase 2 | Completed | Columbia University | 31 | 2008-04-01 | 2015-11-16 |
| Combination of Insulin Sensitizer and Leptin as Treatment for the HAART -Induced Metabolic Syndrome Leptin, Pioglitazone or metformin, Placebo - HIV Lipodystrophy | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 9 | 2006-08-01 | 2017-03-23 |
| Trial of Leptin Replacement Therapy in Patients With Lipodystrophy Leptin, Placebo - Hypoleptinemia, Generalized Lipodystrophy | Phase 2 / Phase 3 | Completed | University of Texas Southwestern Medical Center | 25 | 2006-04-01 | 2024-03-27 |
| A Study of the Functional Magnetic Resonance Imaging Response to Leptin and Pramlintide Pramlintide (Amylin), Placebo (Normal Saline), 2 Metreleptin - Obesity | Not applicable | Unknown | Oregon Health and Science University | 10 | 2006-01-01 | 2022-12-16 |
| Leptin and Endothelial Function leptin - Healthy | Phase 4 | Completed | University of Michigan | 15 | 2004-09-01 | 2006-06-27 |
| Therapeutic Approaches to HAART-Induced Lipodystrophy Leptin, Placebo - HIV Infections, Lipodystrophy | Phase 2 | Completed | University of Texas Southwestern Medical Center | 23 | 2003-01-01 | 2019-05-09 |
| Leptin in Human Energy and Neuroendocrine Homeostasis Subcutaneous Placebo, Leptin - Obesity, Weight Loss | Not applicable | Terminated | Columbia University | 22 | 2002-07-01 | 2019-09-18 |
| In Vivo Leptin Signaling in Humans After Acute Leptin Administration leptin - Lean, Obese | Phase 1 | Completed | Beth Israel Deaconess Medical Center | 12 | 2002-07-01 | 2017-10-17 |
| Leptin to Treat Lipodystrophy Metreleptin - Lipodystrophy | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 103 | 2001-10-01 | 2016-08-16 |
| Effects of Leptin Treatment on Weight Loss Leptin, Very Low Calorie Diet - Obesity | Phase 2 | Completed | Rockefeller University | 40 | 2001-03-01 | 2010-10-19 |
| Low-Dose Leptin and the Formerly-Obese Leptin, Dietary modification, T3 repletion - Obesity | Phase 3 | Unknown | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 25 | 2000-07-01 | 2015-06-04 |
| Recombinant Human Leptin Therapy Effects on Insulin Action placebo, low-dose leptin, high-dose leptin - Type Two Diabetes Mellitus | Not applicable | Completed | Washington University School of Medicine | 18 | 1998-08-01 | 2015-07-09 |
Obesity (7) · Lipodystrophy (3) · Diabetes Mellitus (2) · Insulin Resistance (2) · Overweight (2) · Weight Loss (2) · Cushing Syndrome (1) · Depression, Postpartum (1) · Diabetes Mellitus, Lipoatrophic (1) · Diabetes Mellitus, Type 1 (1) · HIV Infections (1) · HIV-Associated Lipodystrophy Syndrome (1) · Hypertriglyceridemia (1) · Lichen Planus, Oral (1) · Lipodystrophy, Congenital Generalized (1)
Beth Israel Deaconess Medical Center (3) · University of Texas Southwestern Medical Center (3) · Columbia University (2) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Assistance Publique Hopitaux De Marseille (1) · Cairo University (1) · Children's Hospital of Fudan University (1) · Monica Levy Andersen (1) · Oregon Health and Science University (1) · Rockefeller University (1) · University of Michigan (1) · Washington University School of Medicine (1) · Zeynep Kamil Maternity and Pediatric Research and Training Hospital (1)
United States (13) · Brazil (1) · China (1) · Egypt (1) · France (1) · Turkey (Türkiye) (1)
Abhimanyu Garg, M.D. (2) · Abhimanyu Garg, MD (1) · Christos Mantzoros, MD (1) · Christos S Mantzoros, MD (1) · Jeffrey Friedman, MD, PHD (1) · Jonathan Q. Purnell, M.D. (1) · Judith Korner, MD,PhD (1) · Michael Rosenbaum, MD (1) · Olfat Ga Shaker, PHD (1) · Phillip Gorden, M.D. (1) · Weam Ah Rashwan, PHD (1) · Weili Yan, MD, PhD (1)
PMID 19427131, PMID 19727665, PMID 21411512, PMID 22068254, PMID 22965160, PMID 23382191, PMID 24926953, PMID 25070319, PMID 25469244, PMID 25734254, PMID 26589105, PMID 26748249, PMID 26900642, PMID 28324110, PMID 29920214, PMID 31194872, PMID 34223895, PMID 34677608, PMID 37595266
R01DK064773 (1), R01DK079929 (1), R21DK081050 (1), UL1RR024156 (1)