13 completed. 13 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 13 |
| Phase 1 | 4 | Completed 4 |
Follow Desmoid Tumors: new trials by email Literature Review of Desmoid Tumors trials Research Report on Desmoid Tumors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor vactosertib/imatinib combination - Desmoid Tumor | Phase 1 / Phase 2 | Completed | Hyo Song Kim | 24 | 2019-04-15 | 2024-05-13 |
| Doxorubicin Eluting Intra-arterial Embolization for Aggressive Desmoid Fibromatosis Drug Eluting Bead Embolization (DEB) for Desmoid Fibromatosis - Desmoid, Desmoid Fibromatosis of Skin | Phase 2 | Completed | Rabin Medical Center | 8 | 2018-10-11 | 2022-03-25 |
| Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers Nab-Rapamycin, Nivolumab - Ewing Sarcoma, PEComa | Phase 1 / Phase 2 | Completed | Sarcoma Oncology Research Center, LLC | 34 | 2017-08-24 | 2025-02-17 |
| Trial of Nab-paclitaxel in Patients With Desmoid Tumors and Multiply Relapsed/Refractory Desmoplastic Small Round Cell Tumors and Ewing Sarcoma nab paclitaxel - Tumor, Desmoplastic Small Round Cell, Adult, Tumor, Desmoplastic Small Round Cell, Childhood | Phase 2 | Completed | Grupo Espanol de Investigacion en Sarcomas | 69 | 2017-05-09 | 2022-06-07 |
| A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis Sirolimus - Desmoid Tumor | Phase 1 / Phase 2 | Completed | MaineHealth | 9 | 2014-02-01 | 2023-06-26 |
| Phase II Trial of the Gamma-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors/Aggressive Fibromatosis PF-03084014 - Desmoid Tumors, Aggressive Fibromatosis | Phase 2 | Completed | National Cancer Institute (NCI) | 17 | 2013-10-31 | 2024-02-06 |
| Study to Evaluate Imatinib in Desmoid Tumors Imatinib - Aggressive Fibromatosis, Desmoid Tumor | Phase 2 | Completed | Heidelberg University | 39 | 2010-06-01 | 2017-05-03 |
| Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas sunitinib malate - Adult Malignant Fibrous Histiocytoma of Bone, Desmoid Tumor | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 53 | 2007-04-01 | 2016-01-20 |
| Imatinib Mesylate in Treating Patients With Recurrent or Refractory Fibromatosis imatinib mesylate - Desmoid Tumor | Phase 1 / Phase 2 | Completed | UNICANCER | 40 | 2004-09-01 | 2016-08-30 |
| Sulindac and Tamoxifen in Treating Patients With Desmoid Tumor tamoxifen citrate, sulindac, laboratory biomarker analysis - Desmoid Tumor | Phase 2 | Completed | Children's Oncology Group | 70 | 2004-02-01 | 2020-02-19 |
| Radiation Therapy in Treating Patients With Aggressive Fibromatoses radiation therapy - Desmoid Tumor | Phase 2 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 44 | 2001-11-01 | 2013-08-27 |
| Vinblastine and Methotrexate in Treating Children With Desmoid Tumors methotrexate, vinblastine sulfate - Desmoid Tumor | Phase 2 | Completed | Children's Oncology Group | 28 | 1997-08-01 | 2014-07-25 |
| Toremifene in Treating Patients With Desmoid Tumors toremifene, conventional surgery - Desmoid Tumor | Phase 2 | Completed | Advocate Lutheran General Hospital | 72 | 1991-07-01 | 2013-07-10 |
Sarcoma (3) · Desmoplastic Small Round Cell Tumor (2) · Sarcoma, Ewing (2) · AIDS-related Kaposi sarcoma (1) · Bone Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Renal Cell (1) · Carcinoma, Squamous Cell (1) · Carcinoma, Transitional Cell (1) · Chondrosarcoma (1) · Chondrosarcoma, Extraskeletal Myxoid (1) · Chordoma (1) · Colorectal Neoplasms (1)
Fibroma (13) · Neoplasms by Histologic Type (13) · Neoplasms, Connective Tissue (13) · Neoplasms, Connective and Soft Tissue (13) · Neoplasms, Fibrous Tissue (13) · Neoplasms (12) · Neoplasms, Bone Tissue (3) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Neoplasms by Site (2) · Neoplasms, Germ Cell and Embryonal (2) · Neoplasms, Glandular and Epithelial (2) · Neoplasms, Nerve Tissue (2) · Neuroectodermal Tumors (2) · Osteosarcoma (2)
Imatinib Mesylate (2) · Albumin-Bound Paclitaxel (1) · Methotrexate (1) · Nivolumab (1) · Radiotherapy (1) · Sirolimus (1) · Sulindac (1) · Sunitinib (1) · Tamoxifen (1) · Taxes (1) · Toremifene (1) · Vinblastine (1) · nirogacestat (1) · vactosertib (1)
Children's Oncology Group (2) · Advocate Lutheran General Hospital (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Grupo Espanol de Investigacion en Sarcomas (1) · Heidelberg University (1) · Hyo Song Kim (1) · MaineHealth (1) · Memorial Sloan Kettering Cancer Center (1) · National Cancer Institute (NCI) (1) · Rabin Medical Center (1) · Sarcoma Oncology Research Center, LLC (1) · UNICANCER (1)
United States (7) · France (2) · Germany (2) · Australia (1) · Belgium (1) · Canada (1) · Israel (1) · Netherlands (1) · Poland (1) · South Korea (1) · Spain (1) · Switzerland (1) · United Kingdom (1)
Aaron R Weiss, DO (1) · Bernd Kasper, PD Dr. med. (1) · Brian L. Samuels, MD (1) · Bruce Himelstein, MD (1) · Erlinda M Gordon, MD (1) · Francisco Bautista, MD (1) · Geraldine H O'Sullivan Coyne, M.D. (1) · Jaume Mora, MD (1) · Javier Martin Broto, MD (1) · Jean-Yves Blay, MD, PhD (1) · Mary L. Keohan, MD (1) · R. B. Keus, MD (1)
PMID 17290057, PMID 19451429, PMID 20622000, PMID 24089446, PMID 26861905, PMID 28282612, PMID 28350521, PMID 31401903
2016 (1), P30CA008748 (1), U10CA098543 (1)