15 unknown, 12 completed, 3 recruiting, 2 withdrawn. 11 Phase 3, 8 Phase 2, 6 Phase 1, 5 Not applicable, 1 Phase 4.
Follow Corneal Ectasia: new trials by email Literature Review of Corneal Ectasia trials Research Report on Corneal Ectasia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Outcomes of CTAK Surgery Questionnaire and Physical Exam - Keratoconus, Corneal Ectasia | Phase 4 | Not yet recruiting | Stanford University | 100 | 2026-05-01 | 2026-04-24 |
| Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light - Keratoconus, Corneal Ectasia | Phase 2 / Phase 3 | Recruiting | Price Vision Group | 500 | 2025-10-01 | 2026-09-25 |
| KeratoConus Data Acquisition With Topography and Aberrometry Ocular Topography and Wavefront Aberrometry - Corneal Ectasia, Keratoconus | Not applicable | Completed | Azalea Vision | 52 | 2025-06-16 | 2026-01-09 |
| Corneal Topographic Changes in Different Grades of OSA Pentacam (corneal topographic changes detection), Polysymnography - Corneal Ectasia | Completed | Sohag University | 60 | 2024-01-01 | 2025-05-02 | |
| Refractive and Corneal Topographic Characteristics in Upper Egypt Children With High Cylinder Pentacam and autorefractometry - Corneal Ectasia | Completed | Sohag University | 4000 | 2023-01-01 | 2024-04-09 | |
| Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light riboflavin ophthalmic solution - Keratoconus, Corneal Ectasia | Phase 3 | Unknown | Cornea and Laser Eye Institute | 170 | 2021-07-30 | 2023-01-04 |
| Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia Riboflavin - Keratoconus, Corneal Ectasia | Phase 3 | Unknown | Cornea and Laser Eye Institute | 160 | 2021-06-02 | 2023-01-04 |
| Development of a Keratoconus Detection Algorithm by Deep Learning Analysis and Its Validation on Eyestar Images Corneal tomography with Eyestar 900, Corneal tomography with Pentacam, Biometry with IOL-Master - Keratoconus, Eye Diseases | Unknown | Insel Gruppe AG, University Hospital Bern | 4800 | 2021-05-11 | 2021-09-30 | |
| Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose Riboflavin - Keratoconus, Corneal Ectasia | Phase 3 | Unknown | Cornea and Laser Eye Institute | 170 | 2021-04-16 | 2023-01-04 |
| Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution PXL-330 Platinum device for crosslinking with Peschke riboflavin solution - Keratoconus, Pellucid Marginal Corneal Degeneration | Phase 1 | Completed | Cornea Associates of Texas | 249 | 2021-02-01 | 2025-02-11 |
| Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism Wavefront Guided Scleral Lenses, Traditional Scleral Lenses - Keratoconus, Irregular Astigmatism | Not applicable | Unknown | Cornea and Laser Eye Institute | 100 | 2021-01-15 | 2024-05-03 |
| Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics Corneal biomechanics (Corvis ST, Oculus, Wetzlar, Germany), Corneal topography and tomography (Pentacam, Oculus, Wetzlar, Germany), Optic nerve head measurement - Corneal Ectasia, Corneal Disease | Completed | Technische Universität Dresden | 372 | 2020-07-09 | 2022-08-11 | |
| Safety and Effectiveness of the PXL-Platinum 330 System PXL-330 Platinum device for crosslinking with Peschke riboflavin solution - Corneal Ectasia, Keratoconus | Phase 1 / Phase 2 | Unknown | Colorado Eye Consultants/Cornea Consultants of Colorado | 300 | 2020-06-01 | 2022-01-25 |
| Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution PXL-330 Platinum device for crosslinking with Peschke riboflavin solution - Keratoconus, Pellucid Marginal Corneal Degeneration | Phase 1 | Completed | Cornea Associates of Texas | 200 | 2020-01-10 | 2022-10-19 |
| Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia PXL-330 Platinum device for crosslinking with Peschke riboflavin solution - Keratoconus, Pellucid Marginal Corneal Degeneration | Phase 2 | Recruiting | Goodman Eye Center | 500 | 2019-10-19 | 2025-10-20 |
| Cornea Ectasia Excimer Laser Treatment topographic guided trans epithelial excimer laser - Corneal Ectasia | Completed | Bambino Gesù Hospital and Research Institute | 8 | 2019-10-01 | 2020-05-28 | |
| Safety and Preliminary Efficacy of IVMED-80 Eye Drops in Keratoconus Patients IVMED-80, Placebo - Keratoconus, Corneal Ectasia | Phase 1 / Phase 2 | Completed | iVeena Delivery Systems, Inc. | 38 | 2019-02-08 | 2022-02-15 |
| Evaluating Risk Factors of Post-LASIK Ectasia Corneal Ectasia | Unknown | Assiut University | 25 | 2018-12-10 | 2018-10-17 | |
| Three Different Cross-linking Protocols for Treatment of Pediatric Keratoconus Standard CXL, Accelerated CXL, Transepithelial CXL - Corneal Ectasia | Not applicable | Completed | Sohag University | 97 | 2018-06-01 | 2023-03-31 |
| Dresden Corneal Disease and Treatment Study corneal cross-linking, corneal topography and tomography - Corneal Ectasia, Corneal Disease | Recruiting | Technische Universität Dresden | 700 | 2018-03-12 | 2023-02-28 |
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Keratoconus (26) · Corneal Diseases (7) · Dilatation, Pathologic (6) · Astigmatism (3) · Eye Diseases (2) · Cataract (1) · Corneal Wavefront Aberration (1) · Glaucoma (1) · Glaucoma, Open-Angle (1) · Graves Ophthalmopathy (1) · Low Tension Glaucoma (1) · Myopia (1)
Eye Diseases (25) · Corneal Diseases (19) · Pathological Conditions, Anatomical (6) · Pathological Conditions, Signs and Symptoms (6) · Refractive Errors (4) · Autoimmune Diseases (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Endocrine System Diseases (1) · Exophthalmos (1) · Eye Diseases, Hereditary (1) · Genetic Diseases, Inborn (1) · Goiter (1) · Graves Disease (1) · Hyperthyroidism (1) · Immune System Diseases (1)
Riboflavin (11) · Corneal Cross-Linking (6) · Corneal Topography (2) · Dextrans (2) · Ophthalmic Solutions (2) · Tomography (2) · Biometry (1) · Chromatin Immunoprecipitation Sequencing (1) · Hypromellose Derivatives (1) · Keratomileusis, Laser In Situ (1) · Radiation (1) · Radiotherapy (1) · Restraint, Physical (1) · Surveys and Questionnaires (1) · Vision, Ocular (1)
Cornea and Laser Eye Institute (7) · Sohag University (3) · Cornea Associates of Texas (2) · Glaukos Corporation (2) · Technische Universität Dresden (2) · Ameera Gamal Abdelhameed (1) · American-European Congress of Ophthalmic Surgery (1) · Assiut University (1) · Azalea Vision (1) · Bambino Gesù Hospital and Research Institute (1) · Colorado Eye Consultants/Cornea Consultants of Colorado (1) · Emory University (1) · Goodman Eye Center (1) · Insel Gruppe AG, University Hospital Bern (1) · Mercy Center for Corrective Eye Surgery (1)
United States (19) · Egypt (4) · Germany (3) · Belgium (1) · Italy (1) · Mexico (1) · Netherlands (1) · Puerto Rico (1) · Singapore (1) · Switzerland (1)
Peter S Hersh, MD (3) · Elshimaa A.Mateen (2) · Peter Hersh, MD (2) · Steven A Greenstein, MD (2) · Arturo Chayet, MD (1) · Balamurali K. Ambati, MD, PhD (1) · Francis Price, MD (1) · Frederik Raiskup, MD, PhD (1) · John D Gelles, OD (1) · John Vukich, MD (1) · Kerry Stephens (1) · Khaled A. Mohamed, Lecturer (1) · Li Lim (1)
PMID 16765803, PMID 16952090, PMID 18471635, PMID 18811118, PMID 20138607, PMID 20164744, PMID 25365551, PMID 32557558, PMID 34059127, PMID 35606839