4 completed. 4 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 4 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Common Variable Immunodeficiency: new trials by email Literature Review of Common Variable Immunodeficiency trials Research Report on Common Variable Immunodeficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Leniolisib for Immune Dysregulation in CVID Leniolisib - Common Variable Immunodeficiency (CVID) | Phase 2 | Completed | Pharming Technologies B.V. | 27 | 2025-02-12 | 2026-09-18 |
| Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation Thiotepa--single daily dose, Thiotepa--escalated dose - Bone Marrow Failure Syndrome, Thalassemia | Phase 1 / Phase 2 | Completed | University of Florida | 6 | 2018-06-15 | 2023-09-15 |
| Study of Efficacy of CDZ173 in Patients With APDS/PASLI CDZ173, Placebo - Common Variable Immunodeficiency (CVID), APDS / PASLI | Phase 2 / Phase 3 | Completed | Novartis Pharmaceuticals | 37 | 2015-08-24 | 2022-08-10 |
| Immune Disorder HSCT Protocol Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan - Immune Deficiency Disorders, Severe Combined Immunodeficiency | Phase 2 | Completed | Washington University School of Medicine | 28 | 2013-04-29 | 2026-10-27 |
Granulomatous Disease, Chronic (2) · Lymphohistiocytosis, Hemophagocytic (2) · Lymphoproliferative Disorders (2) · Severe Combined Immunodeficiency (2) · Wiskott-Aldrich Syndrome (2) · Activated PI3K-delta Syndrome (1) · Adrenoleukodystrophy (1) · Anemia, Diamond-Blackfan (1) · Anemia, Hemolytic (1) · Anemia, Sickle Cell (1) · Autoimmune Lymphoproliferative Syndrome (1) · Bone Marrow Failure Disorders (1) · Bruton type agammaglobulinemia (1) · Chediak-Higashi Syndrome (1)
Immune System Diseases (3) · Immunologic Deficiency Syndromes (3) · Blood Coagulation Disorders (2) · Blood Coagulation Disorders, Inherited (2) · Chronic Disease (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Cytopenia (2) · DNA Repair-Deficiency Disorders (2) · Disease Attributes (2) · Endocrine System Diseases (2) · Genetic Diseases, Inborn (2) · Genetic Diseases, X-Linked (2) · Hematologic Diseases (2) · Hemic and Lymphatic Diseases (2) · Hemorrhagic Disorders (2)
leniolisib (2) · Melphalan (1) · Thiotepa (1) · fludarabine (1)
Novartis Pharmaceuticals (1) · Pharming Technologies B.V. (1) · University of Florida (1) · Washington University School of Medicine (1)
United States (4) · United Kingdom (2) · Belarus (1) · Czechia (1) · Germany (1) · Ireland (1) · Italy (1) · Netherlands (1) · Russia (1) · Spain (1)
Biljana Horn, MD (1) · Koneti V Rao, MD (1) · Virgil Dalm, MD (1)
PMID 28972011, PMID 31599480, PMID 36399712, PMID 41091701
2014 (1)