106 completed, 47 recruiting, 30 terminated, 25 active not recruiting. 77 Phase 2, 66 Not applicable, 66 Phase 1, 16 Phase 3, 4 Phase 4.
Follow Colorectal Carcinoma: new trials by email Literature Review of Colorectal Carcinoma trials Research Report on Colorectal Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Effects of Exercise on Colorectal Cancer Development After Treatment With Pelvic Radiation Therapy for Prostate Cancer Aerobic Exercise, Biopsy Procedure, Biospecimen Collection - Colon Polyp, Colorectal Carcinoma | Not applicable | Recruiting | City of Hope Medical Center | 30 | 2026-12-16 | 2026-08-28 |
| Smart Symptom Tracking ALEX Application for Tracking and Monitoring Gastrointestinal Health, Smart Horizons Pilot Trial Artificial Intelligence-based Intervention, Best Practice, Communication Intervention - Colorectal Carcinoma | Not applicable | Recruiting | Mayo Clinic | 50 | 2026-04-20 | 2026-06-05 |
| Culturally Adapting an Intervention to Increase Genetic Testing in African American Cancer Survivors Culturally adapted Online Genetic Counseling and Testing Information - Female Breast Cancer, Prostate Cancer | Not applicable | Recruiting | Barbara Ann Karmanos Cancer Institute | 85 | 2026-04-18 | 2026-06-23 |
| Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment Zanidatamab, Resection, Patient Observation - Colon Carcinoma, Colorectal Carcinoma | Phase 2 | Recruiting | Emory University | 38 | 2026-04-07 | 2026-04-17 |
| An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis Biopsy Procedure, Biospecimen Collection, EP2/EP4 Antagonist TPST-1495 - Colorectal Carcinoma, Familial Adenomatous Polyposis | Phase 2 | Recruiting | National Cancer Institute (NCI) | 38 | 2026-03-31 | 2026-09-14 |
| The Association Between Deep Endometriosis and the Occurrence of Colorectal Carcinoma Endometriosis, Deep Endometriosis | Not yet recruiting | University Medical Centre Ljubljana | 30 | 2026-02-01 | 2026-02-06 | |
| A Self-Monitoring Platform for Tracking Medication Safety and Concerns in Cancer Patients Educational Intervention, Electronic Health Record Review, Follow-Up - Breast Carcinoma, Colorectal Carcinoma | Not applicable | Recruiting | University of Michigan Rogel Cancer Center | 80 | 2026-01-09 | 2026-01-21 |
| The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas Cancer Therapeutic Procedure, Questionnaire Administration - Amyloidosis, Basal Cell Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 27 | 2025-12-18 | 2026-09-30 |
| A Multilevel Intervention to Increase Colorectal Cancer Screening Tests in Patients With Abnormal Fecal Immunochemical Test Results, PROACT Trial Best Practice, Educational Intervention, Electronic Health Record Review - Colorectal Carcinoma | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 682 | 2025-12-16 | 2026-06-22 |
| Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene. Zanidatamab - Non-Small Cell Lung Cancer, Sarcoma | Phase 2 | Recruiting | UNICANCER | 105 | 2025-10-30 | 2025-12-19 |
| Testing for Safety and Colorectal Cancer Preventive Effects of ONC201 Biopsy Procedure, Biospecimen Collection, Colonoscopy - Colorectal Adenomatous Polyp, Colorectal Carcinoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 36 | 2025-10-06 | 2026-10-15 |
| 5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemotherapy With Advanced Unresectab Administration of experimental treatment association (sotorasib, panitumumab 5FU) - Colorectal Carcinoma, KRAS G12C Mutation | Phase 2 | Not yet recruiting | Federation Francophone de Cancerologie Digestive | 300 | 2025-08-31 | 2025-08-15 |
| Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors CP-383 - Solid Tumor Malignancies, Colorectal Carcinoma | Phase 1 / Phase 2 | Recruiting | Tasca Therapeutics | 150 | 2025-08-27 | 2026-02-18 |
| Efficacy Study of Digoxin Combined With Serplulimab and Chemotherapy in First-Line Treatment of MSS Advanced Colorectal Cancer Digoxin, Fuquinitinib, Tislelizumab - Colorectal Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Fudan University | 20 | 2025-08-01 | 2025-08-01 |
| Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers Computed Tomography, Fludeoxyglucose F-18, Gallium Ga 68 FAPi-46 - Anal Carcinoma, Bladder Carcinoma | Phase 1 | Active not recruiting | Jonsson Comprehensive Cancer Center | 30 | 2025-08-01 | 2026-10-20 |
| A Long-Term Follow-Up Study of Participants Treated With A2 Biotherapeutics (A2 Bio) Gene Therapy (GT) Products No additional intervention administered in this long term follow-up study - Solid Tumor Cancer, Solid Tumor, Unspecified, Adult | Enrolling by invitation | A2 Biotherapeutics Inc. | 400 | 2025-07-31 | 2026-05-20 | |
| Evaluating the Effects of an Exercise Intervention on the Gut Microbiota in Stage II-III Colorectal Cancer Survivors Biospecimen Collection, Exercise Intervention, Health Education - Stage II Colorectal Cancer AJCC v8, Stage III Colorectal Cancer AJCC v8 | Not applicable | Terminated | Fred Hutchinson Cancer Center | 10 | 2025-07-08 | 2026-09-02 |
| Rectus Sheath Catheters Following Midline Laparotomy Ropivacaine 0.2%, Saline 0.9% - Acute Abdomen, Ileus | Not applicable | Not yet recruiting | Asklepios Kliniken Hamburg GmbH | 40 | 2025-07-01 | 2025-08-01 |
| New bioMarkers tO straTIfy cOlorectal caNcer Referrals Colorectal Carcinoma, Polyp | Recruiting | Queen Mary University of London | 582 | 2025-06-30 | 2026-09-08 | |
| The Vanguard Study: Testing a New Way to Screen for Cancer Biospecimen Collection, Device Usage, Electronic Health Record Review - Bladder Carcinoma, Breast Carcinoma | Not applicable | Recruiting | National Cancer Institute (NCI) | 24000 | 2025-06-18 | 2026-10-06 |
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Colorectal Neoplasms (242) · Breast Neoplasms (28) · Colonic Neoplasms (26) · Carcinoma, Non-Small-Cell Lung (24) · Ovarian Neoplasms (21) · Pancreatic Neoplasms (21) · Prostatic Neoplasms (20) · Carcinoma, Renal Cell (17) · Stomach Neoplasms (17) · Melanoma (16) · Lung Neoplasms (15) · Rectal Neoplasms (14) · Squamous Cell Carcinoma of Head and Neck (14) · Carcinoma, Hepatocellular (13) · Neoplasm Metastasis (13)
Digestive System Neoplasms (242) · Gastrointestinal Diseases (242) · Intestinal Diseases (242) · Intestinal Neoplasms (242) · Neoplasms by Site (242) · Colonic Diseases (241) · Digestive System Diseases (241) · Rectal Diseases (241) · Gastrointestinal Neoplasms (239) · Neoplasms (229) · Neoplasms by Histologic Type (55) · Neoplasms, Glandular and Epithelial (48) · Urogenital Diseases (46) · Urogenital Neoplasms (45) · Genital Diseases (40)
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National Cancer Institute (NCI) (19) · Fred Hutchinson Cancer Center (7) · Eli Lilly and Company (6) · Ohio State University Comprehensive Cancer Center (6) · City of Hope Medical Center (5) · Fudan University (5) · M.D. Anderson Cancer Center (5) · Emory University (4) · Jonsson Comprehensive Cancer Center (4) · Mayo Clinic (4) · Memorial Sloan Kettering Cancer Center (4) · University of Southern California (4) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (3) · H. Lee Moffitt Cancer Center and Research Institute (3) · Merck Sharp & Dohme LLC (3)
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Tim F Greten, M.D. (4) · Andrea Cercek, MD (2) · Clement Gwede, Ph.D. (2) · Eduardo Vilar-Sanchez (2) · Electra D Paskett, PhD (2) · Lin Yang, Ph.D. (2) · Linda Ko (2) · Michael Sawyer, MD (2) · Neil Kopek, M.D. (2) · Peter Klare, MD (2) · Adriana M Coletta, PhD (1)
PMID 36064325, PMID 30679026, PMID 31378656, PMID 36606664, PMID 12229948, PMID 15383798, PMID 15496622, PMID 15623449, PMID 15640382, PMID 15868235, PMID 15914748, PMID 16177017, PMID 16813588, PMID 16822842, PMID 16822843, PMID 16822844, PMID 16971718, PMID 16983741, PMID 17008704, PMID 17175450, PMID 17785709, PMID 17968156, PMID 18452860, PMID 18836202, PMID 19269519, PMID 20395841, PMID 20500867, PMID 20525328, PMID 20632311, PMID 20692872, PMID 20818844, PMID 21596621, PMID 21831177, PMID 21861071, PMID 22067400, PMID 22256804, PMID 22539154, PMID 23114473, PMID 24013470, PMID 24495589, PMID 25487708, PMID 25980594, PMID 26123286, PMID 26156652, PMID 26460303, PMID 26586415, PMID 26903575, PMID 27194579, PMID 27282451, PMID 27448051
P30CA014089 (4), P30CA015704 (4), P30CA060553 (4), 2015 (3), 2017 (3), P30CA033572 (3), UG1CA242609 (3), 2008 (2), 2014 (2), 2016 (2), 2023 (2), 2025 (2), N01CN00042 (2), P30CA015083 (2), P30CA016672 (2)