The Association Between Deep Endometriosis and the Occurrence of Colorectal Carcinoma

NCT07386431 — Not yet recruiting, 30 participants, University Medical Centre Ljubljana

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Registry	NCT07386431
Status	Not yet recruiting
Study type	Observational
Enrollment	30 (Estimated)
Sponsor	University Medical Centre Ljubljana (Other)
Conditions	Endometriosis, Deep Endometriosis, Bowel Endometriosis, Colorectal Carcinoma, Colon Resection, Endometriosis Pelvic, Endometriosis Rectum, Carcinogenesis, Genetic Change, Infertility
Dates	start 2026-02-01 (estimated), primary completion 2028-10-01 (estimated), completion 2029-05-01 (estimated), first posted 2026-02-04, last updated 2026-02-06

-Summary

The goal of this study is to identify the molecular or genetic mechanisms that may predispose patients with bowel endometriosis to an increased risk of colorectal carcinoma. The study will include patients for whom surgical treatment of bowel endometriosis is clinically indicated.

This research would represent a significant advancement in evaluating the necessity of surgical intervention in asymptomatic patients or those with mild symptoms. Furthermore, it would provide a broader insight into the systemic impact of endometriosis on other organ systems, ultimately improving risk assessment and preventive measures.

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+Outcome measures

Primary outcomes

Comparison of gene expression in healthy and with endometriosis affected bowel. [3 years]

+Eligibility

Sex: Female, ages: 18 Years to any

Inclusion Criteria:

Female patients aged 18 and over, treated at the Department of Reproduction for diagnosed deep endometriosis, including bowel endometriosis, for whom surgical treatment is indicated.

Exclusion Criteria:

* Patients with known inflammatory bowel disease (IBD), patients with a personal history of gynecological or gastrointestinal malignancy