15 completed, 6 unknown, 3 terminated, 2 recruiting. 16 Not applicable, 5 Phase 2, 3 Phase 3, 2 Phase 1, 2 Phase 4.
Follow Chronic Kidney Disease stage4: new trials by email Literature Review of Chronic Kidney Disease stage4 trials Research Report on Chronic Kidney Disease stage4
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Feasibility, Safety and Efficacy of a Predominantly Plant-based Diet in an Asian Population With Chronic Kidney Disease Predominantly Plant-Based CKD Diet, Standard CKD Diet - Chronic Kidney Disease stage3, Chronic Kidney Disease stage4 | Not applicable | Recruiting | Changi General Hospital | 40 | 2026-04-01 | 2026-04-22 |
| Effects of Brazil Nut Supplementation in Patients With Chronic Kidney Disease Undergoing Conservative Treatment Brazil Nut - Chronic Kidney Diseases, Chronic Kidney Disease stage3 | Not applicable | Active not recruiting | Universidade Federal Fluminense | 50 | 2025-03-30 | 2026-05-18 |
| Evaluation of the Safety and Tolerability of Gemini in Subjects With Stage 3-4 Chronic Kidney Disease. Intravenous Gemini, Intravenous placebo - Renal Insufficiency, Chronic, Chronic Kidney Disease stage3 | Phase 1 / Phase 2 | Completed | Revelation Biosciences, Inc | 40 | 2025-01-20 | 2025-10-29 |
| Treatment Optimization for Patients With Type 2 Diabetes Using Empagliflozin and Finerenone in a Remote Clinical Trial Empagliflozin 10 MG, Finerenone, Withings BPM Connect - Diabetes Mellitus Type 2 With Proteinuria, Diabetes Mellitus, Type 2 | Phase 4 | Completed | University Medical Center Groningen | 12 | 2024-07-29 | 2026-02-13 |
| Evaluation of a Multidisciplinary Care Pathway on the Evolution of Renal Function in Patients With Advanced Chronic Kidney Disease Evolution of renal function, Measurement of haemoglobin levels, Measurement of biological parameters - Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5 | Unknown | Centre Hospitalier Universitaire de Saint Etienne | 535 | 2024-04-09 | 2024-07-10 | |
| Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD GLP-1 receptor agonist, SGLT2 inhibitor, Tirzepatide - Chronic Kidney Disease stage3, Chronic Kidney Disease stage4 | Recruiting | Cardenal Herrera University | 250 | 2023-09-15 | 2025-12-30 | |
| Validation and Evaluation of a Newly Developed Mobile Diet App Counseling, Renal Diet App, Printed Nutrition Pamphlet - Chronic Kidney Diseases, Chronic Kidney Disease stage3 | Not applicable | Unknown | Universiti Putra Malaysia | 90 | 2023-02-15 | 2023-01-27 |
| A Pragmatic Approach to CKD Patient Education CKD "What You Need To Know" Workbook System, CKD Action Plan, CKD Web-based Resource List - Chronic Kidney Disease stage3, Chronic Kidney Disease stage4 | Not applicable | Terminated | University of Arkansas | 1 | 2023-02-13 | 2026-01-07 |
| Phase 3 Safety and Efficacy Study of CTAP101 Extended-release Capsules in Children With Secondary Hyperparathyroidism CTAP101, Placebo - Chronic Kidney Disease stage3, Chronic Kidney Disease stage4 | Phase 3 | Terminated | OPKO Health, Inc. | 2 | 2023-01-31 | 2025-07-25 |
| Safety and Clinical and Virologic Outcomes in CKD Patients Treated With Nirmatrelvir-ritonavir Nirmatrelvir/ritonavir - COVID-19, Chronic Kidney Disease stage4 | Completed | Chinese University of Hong Kong | 85 | 2022-11-07 | 2024-02-07 | |
| Low-Protein Diet With Low-Protein Foods Versus a LPD Without LP Foods in Patients With Chronic Kidney Disease (CKD) Consumption of FLAVIS - Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4 | Not applicable | Completed | Dr. Schär AG / SPA | 210 | 2022-11-06 | 2026-08-17 |
| Study of Sulphoraphane in Chronic Kidney Disease Sulforaphane - Chronic Kidney Disease stage3, Chronic Kidney Disease stage4 | Phase 1 | Completed | University of Rochester | 18 | 2022-05-02 | 2024-08-12 |
| Rollover Extension Clinical Trial To Evaluate The Long-Term Safety And Efficacy Of KT-301 (Formerly US-APR2020) In Subjects With CKD IV Completing The US-APR2020-01 Study KT-301 (formerly US-APR2020) - Chronic Kidney Disease stage4 | Phase 2 / Phase 3 | Suspended | Kibow Pharma | 600 | 2022-04-21 | 2024-09-19 |
| PR-0164 First in Human Clinical Trial of the PAVmed PortIO Intraosseous Infusion System PAVmed PortIO™ Intraosseous Infusion System - Chronic Kidney Disease stage3, Chronic Kidney Disease stage4 | Not applicable | Completed | PAVmed Inc. | 15 | 2022-01-20 | 2025-06-27 |
| Effect of Broccoli Sprout Extract in Patients With Chronic Kidney Disease With Diabetes Type 2 Sulforaphane, administered as Broccoli sprout extract - Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4 | Not applicable | Completed | Karolinska Institutet | 100 | 2021-10-10 | 2024-03-04 |
| Living With CKD: An E-Learning Platform for Adolescents With CKD About the Disease and Its Management My Kidney Guru - Chronic Kidney Diseases, Chronic Kidney Disease stage3 | Not applicable | Completed | 3-C Institute for Social Development | 67 | 2021-09-01 | 2022-11-30 |
| Clinical Trial To Evaluate Safety And Efficacy Of KT-301 (Formerly US-APR2020) In Subjects With Chronic Kidney Disease Stage IV US-APR2020, Placebo - Chronic Kidney Disease stage4 | Phase 2 | Suspended | Kibow Pharma | 630 | 2021-06-24 | 2024-09-19 |
| Effect of a CKD Dashboard on Patient Activation and Shared Decision Making CKD dashboard - Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4 | Not applicable | Completed | St. Antonius Hospital | 150 | 2021-01-04 | 2023-07-06 |
| Healthy Diet Rich in Potassium to Chronic Kidney Disease With Sodium Zirconium Cyclosilicate: A Feasibility Study sodium zirconium cyclosilicate and healthy diet - Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5 | Not applicable | Completed | Karolinska Institutet | 26 | 2020-11-03 | 2023-05-23 |
| Physiopathology of Neuromuscular Function Related to Fatigue in Chronic Renal Disease Handgrip fatigability test, Questionnaires - Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4 | Not applicable | Terminated | Centre Hospitalier le Mans | 161 | 2020-06-22 | 2026-07-01 |
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Renal Insufficiency, Chronic (16) · Diabetes Mellitus, Type 2 (4) · Inflammation (2) · Patient Participation (2) · Albuminuria (1) · COVID-19 (1) · Coronary Artery Disease (1) · Diabetes Complications (1) · Diabetes Mellitus (1) · Diabetic Nephropathies (1) · Fatigue (1) · Feeding Behavior (1) · Glomerulonephritis (1) · Hyperkalemia (1) · Hyperparathyroidism, Secondary (1)
Female Urogenital Diseases (18) · Female Urogenital Diseases and Pregnancy Complications (18) · Male Urogenital Diseases (18) · Urogenital Diseases (18) · Urologic Diseases (18) · Kidney Diseases (17) · Chronic Disease (16) · Disease Attributes (16) · Pathologic Processes (16) · Pathological Conditions, Signs and Symptoms (16) · Renal Insufficiency (16) · Nutritional and Metabolic Diseases (6) · Behavior (5) · Endocrine System Diseases (5) · Metabolic Diseases (5)
empagliflozin (3) · Counseling (2) · sulforaphane (2) · 2S albumin, brazil nut (1) · Angiotensin-Converting Enzyme Inhibitors (1) · Canagliflozin (1) · Diet, Healthy (1) · Digital Technology (1) · Exenatide (1) · Liraglutide (1) · Metformin (1) · Renal Dialysis (1) · Sodium-Glucose Transporter 2 Inhibitors (1) · Surveys and Questionnaires (1) · Tirzepatide (1)
Karolinska Institutet (2) · Kibow Pharma (2) · 3-C Institute for Social Development (1) · Calydial (1) · Cardenal Herrera University (1) · Centre Hospitalier Universitaire de Besancon (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Centre Hospitalier le Mans (1) · Changi General Hospital (1) · Chinese University of Hong Kong (1) · Dr. Schär AG / SPA (1) · Erasmus Medical Center (1) · Imam Khomeini Hospital (1) · Jemincare (1) · Medical University of Vienna (1)
United States (9) · France (5) · Netherlands (3) · Sweden (2) · Austria (1) · Brazil (1) · Colombia (1) · Hong Kong (1) · Iran (1) · Malaysia (1) · Singapore (1) · Spain (1) · Taiwan (1)
Akhtar Ashfaq, MD (1) · Ana Checa-Ros, MD, PhD (1) · Carla Avesani, PhD (1) · Debra Childress, PHD (1) · Gisella Lopez (1) · Hiddo Lambers Heerspink (1) · Khosro Barkhordari, MD (1) · Laetitia Koppe, Dr (1) · Lim Jun Hao, Dietitian (1) · Luis D'Marco, MD, PhD (1) · Manfred Hecking, MD (1)
PMID 22870215, PMID 25959301, PMID 32711479, PMID 33320101, PMID 37531093, PMID 38770818, PMID 39032787, PMID 42054883, PMID 42530392, PMID 42865317
R01DK128677 (1)