12 completed, 1 terminated, 1 withdrawn. 9 Phase 1, 2 Phase 2, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 8, Terminated 1 |
| Phase 2 | 2 | Completed 2 |
| Not applicable | 1 | Withdrawn 1 |
Follow Childhood Supratentorial Ependymoma: new trials by email Literature Review of Childhood Supratentorial Ependymoma trials Research Report on Childhood Supratentorial Ependymoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors gallium Ga 68-edotreotide, positron emission tomography, computed tomography - Acoustic Schwannoma, Adult Anaplastic Astrocytoma | Not applicable | Withdrawn | Sue O'Dorisio | 2013-09-01 | 2017-04-28 | |
| Study of Tumor Samples From Patients With Ependymoma Treated on the Children's Oncology Group ACNS0121 Trial laboratory biomarker analysis - Childhood Infratentorial Ependymoma, Childhood Supratentorial Ependymoma | Completed | Children's Oncology Group | 80 | 2012-03-01 | 2016-05-18 | |
| Sunitinib Malate in Treating Younger Patients With Recurrent, Refractory, or Progressive Malignant Glioma or Ependymoma Diagnostic Laboratory Biomarker Analysis, Pharmacological Study, Sunitinib Malate - Childhood Cerebellar Anaplastic Astrocytoma, Childhood Cerebral Anaplastic Astrocytoma | Phase 2 | Completed | National Cancer Institute (NCI) | 30 | 2012-01-01 | 2015-08-27 |
| Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia gamma-secretase/Notch signalling pathway inhibitor RO4929097, diagnostic laboratory biomarker analysis, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 129 | 2010-03-01 | 2014-11-05 |
| Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors vorinostat, temozolomide, diagnostic laboratory biomarker analysis - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 27 | 2010-02-01 | 2013-05-03 |
| ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors veliparib, temozolomide, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 31 | 2009-07-01 | 2014-07-09 |
| Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma ispinesib, laboratory biomarker analysis, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2006-06-01 | 2013-01-16 |
| AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Cediranib Maleate - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 55 | 2006-03-01 | 2016-03-07 |
| Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors lenalidomide, perfusion-weighted magnetic resonance imaging, diffusion-weighted magnetic resonance imaging - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2004-11-01 | 2013-09-30 |
| Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Cytology Specimen Collection Procedure - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Completed | Children's Oncology Group | 1258 | 2004-02-16 | 2018-07-16 | |
| Cilengitide in Treating Children With Refractory Primary Brain Tumors cilengitide, laboratory biomarker analysis - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2003-07-01 | 2013-09-30 |
| Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors O6-benzylguanine, temozolomide, filgrastim - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 72 | 2002-10-01 | 2013-09-30 |
| FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia romidepsin - Blastic Phase Chronic Myelogenous Leukemia, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2002-09-01 | 2013-01-16 |
| Irinotecan in Treating Children With Refractory Solid Tumors irinotecan hydrochloride - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 2 | Completed | Children's Oncology Group | 181 | 1999-10-01 | 2013-06-14 |
Astrocytoma (13) · Familial ependymoma (13) · Medulloblastoma (12) · Optic Nerve Glioma (12) · Choroid Plexus Neoplasms (11) · Oligodendroglioma (11) · Rhabdoid Tumor (6) · Spinal Cord Neoplasms (6) · Burkitt Lymphoma (2) · Dendritic Cell Sarcoma, Interdigitating (2) · Ependymoma (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Adenoma, Acidophil (1) · Adenoma, Basophil (1) · Adenoma, Chromophobe (1)
Neoplasms (13) · Neoplasms by Histologic Type (13) · Neoplasms, Germ Cell and Embryonal (13) · Neoplasms, Glandular and Epithelial (13) · Neoplasms, Nerve Tissue (13) · Neuroectodermal Tumors (13) · Central Nervous System Diseases (12) · Central Nervous System Neoplasms (12) · Cranial Nerve Diseases (12) · Cranial Nerve Neoplasms (12) · Eye Diseases (12) · Glioma (12) · Neoplasms by Site (12) · Neoplasms, Neuroepithelial (12) · Nervous System Diseases (12)
Temozolomide (3) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · CK0238273 (1) · Calcium Dobesilate (1) · Cilengitide (1) · Dexamethasone (1) · Filgrastim (1) · Granulocyte Colony-Stimulating Factor (1) · Irinotecan (1) · Lenalidomide (1) · Magnetic Resonance Spectroscopy (1) · O(6)-benzylguanine (1) · Sunitinib (1) · Vorinostat (1)
National Cancer Institute (NCI) (10) · Children's Oncology Group (3) · Sue O'Dorisio (1)
United States (14) · Canada (4) · Australia (2) · New Zealand (1) · Puerto Rico (1) · Switzerland (1)
Amar Gajjar (1) · Cynthia Wetmore (1) · Jack Su (1) · Katherine Warren (1) · Lisa Bomgaars (1) · M. Sue O'Dorisio, MD, PhD (1) · Mark Kieran (1) · Maryam Fouladi (1) · Najat Daw (1) · Richard Sills (1) · Scott Pomeroy (1) · Tobey MacDonald (1) · Trent Hummel (1) · Uri Tabori, MD (1)
PMID 23554030, PMID 27109549, PMID 32623479, PMID 33852135
U01CA081457 (5), U01CA097452 (4), U10CA098543 (4), P30CA086862 (1), UG1CA189958 (1)