10 recruiting. 10 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 10 | Recruiting 10 |
| Phase 2 | 5 | Recruiting 5 |
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ATR 1072 in Participants With PRKAG2 Syndrome ATR 1072 - Cardiac Glycogenosis, Cardiomyopathy | Phase 1 / Phase 2 | Recruiting | Atrium Therapeutics | 37 | 2026-09-14 | 2026-09-18 |
| Harmony-HHT: ATV-1601 in Participants With Hereditary Hemorrhagic Telangiectasia (HHT) ATV-1601, Placebo - Hereditary Hemorrhagic Telangiectasia (HHT), Osler Weber Rendu Disease | Phase 1 / Phase 2 | Recruiting | Atavistik Bio, Inc | 100 | 2026-07-27 | 2026-10-26 |
| DIAG723 in Adults With Hereditary Hemorrhagic Telangiectasia DIAG723, Placebo - Hereditary Hemorrhagic Telangiectasia, Pulmonary Arterial Hypertension | Phase 1 / Phase 2 | Recruiting | Diagonal Therapeutics, Inc. | 93 | 2026-06-04 | 2026-09-08 |
| A Multiple Baseline Feasibility Trial of Social Management Training for People With Sex Chromosome Aneuploidies Social Management Training - Sex Chromosome Disorders | Phase 1 | Recruiting | University of Oslo | 30 | 2026-06-01 | 2026-07-22 |
| Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Recruiting | Charite University, Berlin, Germany | 80 | 2025-12-05 | 2026-10-15 |
| Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC TN-401 - Arrhythmogenic Right Ventricular Cardiomyopathy | Phase 1 | Recruiting | Tenaya Therapeutics | 15 | 2024-03-26 | 2025-02-06 |
| A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM) RP-A601 - PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM) | Phase 1 | Recruiting | Rocket Pharmaceuticals Inc. | 9 | 2023-08-29 | 2026-04-16 |
| Autologous Induced Pluripotent Stem Cells of Cardiac Lineage for Congenital Heart Disease iPSC-CL - Univentricular Heart, Congenital Heart Disease | Phase 1 | Recruiting | HeartWorks, Inc. | 50 | 2023-02-03 | 2026-03-13 |
| Beta-blocker Administration for Cardiomyocyte Division N-thymidine, Urine Collection, Echocardiogram - Tetralogy of Fallot, Double Outlet Right Ventricle | Phase 1 | Recruiting | Weill Medical College of Cornell University | 40 | 2022-12-16 | 2026-10-26 |
| Clinical Application of Al18F-NOTA-FAPI-04 PET/CT or PET/MRI Imaging in Malignant Tumor,Cardiovascular or Immune Disease Al18F-NOTA-FAPI PET/CT(or PET/MRI) - Hyperthyroidism, Autoimmune, Cardiovascular Abnormalities | Phase 1 / Phase 2 | Recruiting | Peking Union Medical College Hospital | 600 | 2022-05-10 | 2026-02-10 |
Arrhythmogenic Right Ventricular Dysplasia (2) · Heart Defects, Congenital (2) · Telangiectasia, Hereditary Hemorrhagic (2) · 47, XYY syndrome (1) · Arteriovenous Malformations (1) · Cardiomyopathies (1) · Cardiovascular Diseases (1) · Death, Sudden, Cardiac (1) · Disease (1) · Double Outlet Right Ventricle (1) · Glycogen Storage Disease (1) · Graves Disease (1) · Heart Arrest (1) · Heart Diseases (1)
Congenital Abnormalities (10) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10) · Cardiovascular Diseases (9) · Heart Diseases (6) · Heart Defects, Congenital (5) · Pathological Conditions, Signs and Symptoms (3) · Cardiomyopathies (2) · Endocrine System Diseases (2) · Genetic Diseases, Inborn (2) · Hemic and Lymphatic Diseases (2) · Pathologic Processes (2) · Arrhythmias, Cardiac (1) · Autoimmune Diseases (1) · Carbohydrate Metabolism, Inborn Errors (1)
Capsules (1) · Propranolol (1) · Restraint, Physical (1) · Specimen Handling (1) · Standard of Care (1) · Thymidine (1) · Urine Specimen Collection (1)
Atavistik Bio, Inc (1) · Atrium Therapeutics (1) · Charite University, Berlin, Germany (1) · Diagonal Therapeutics, Inc. (1) · HeartWorks, Inc. (1) · Peking Union Medical College Hospital (1) · Rocket Pharmaceuticals Inc. (1) · Tenaya Therapeutics (1) · University of Oslo (1) · Weill Medical College of Cornell University (1)
United States (6) · Australia (1) · Canada (1) · China (1) · Germany (1) · New Zealand (1) · Norway (1)
Barry Greenberg, MD (1) · Bernhard Kuhn, MD (1) · Timothy J Nelson, M.D., Ph.D. (1)
PMID 34265312, PMID 37979797, PMID 42660999
R01HL155597 (1)