6 active not recruiting. 6 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Active not recruiting 6 |
| Phase 2 | 4 | Active not recruiting 4 |
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trametinib Treatment for Complicated Vascular Anomalies Trametinib tablet - Vascular Anomalies | Phase 1 / Phase 2 | Active not recruiting | West China Hospital | 20 | 2025-07-07 | 2025-07-22 |
| A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT) ALN-6400, Placebo - Hereditary Hemorrhagic Telangiectasia | Phase 1 / Phase 2 | Active not recruiting | Alnylam Pharmaceuticals | 89 | 2024-11-07 | 2026-10-15 |
| Gene Therapy for ACM Due to a PKP2 Pathogenic Variant LX2020 - Arrhythmogenic Cardiomyopathy, PKP2-ACM | Phase 1 / Phase 2 | Active not recruiting | Lexeo Therapeutics | 10 | 2024-02-29 | 2025-11-12 |
| Assess Safety and Efficacy of VAD044 in HHT Patients VAD044 Part I, VAD044 Part II - Hereditary Hemorrhagic Telangiectasia (HHT) | Phase 1 / Phase 2 | Active not recruiting | Vaderis Therapeutics AG | 75 | 2022-07-18 | 2026-03-17 |
| Intramyocardial Injection of Autologous UCB-MNC During Fontan Surgery for SRV Dependent CHD Autologous mononuclear cells - Congenital Heart Disease, SRV Dependent | Phase 1 | Active not recruiting | Timothy J Nelson, MD, PhD | 30 | 2021-06-01 | 2025-06-27 |
| Mesenchymal Stromal Cells for Infants With Congenital Heart Disease (MedCaP) BM-MSC - Congenital Heart Disease (CHD) | Phase 1 | Active not recruiting | Catherine Bollard | 17 | 2020-07-29 | 2026-06-02 |
Heart Defects, Congenital (2) · Telangiectasia, Hereditary Hemorrhagic (2) · Arrhythmogenic Right Ventricular Dysplasia (1) · Arteriovenous Malformations (1) · Cardiomyopathies (1) · Death, Sudden, Cardiac (1) · Epistaxis (1) · Heart Arrest (1) · Hypoplastic Left Heart Syndrome (1) · Vascular Malformations (1)
Cardiovascular Diseases (6) · Congenital Abnormalities (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Heart Diseases (3) · Hematologic Diseases (2) · Hemic and Lymphatic Diseases (2) · Hemorrhagic Disorders (2) · Hemostatic Disorders (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Telangiectasis (2) · Vascular Diseases (2) · Vascular Malformations (2) · Death (1)
trametinib (1)
Alnylam Pharmaceuticals (1) · Catherine Bollard (1) · Lexeo Therapeutics (1) · Timothy J Nelson, MD, PhD (1) · Vaderis Therapeutics AG (1) · West China Hospital (1)
United States (5) · France (2) · Spain (2) · Australia (1) · Belgium (1) · Canada (1) · China (1) · Germany (1) · Italy (1) · Netherlands (1)
Benjamin Peeler, MD (1) · Damien Picard (1) · David M Overman (1) · Harold M Burkhart (1) · James Jaggers, MD (1) · James Tweddell, M.D. (1) · Jason Maynes, MD (1) · John D Cleveland, MD (1) · Joseph Dearani (1) · Richard Jonas, MD (1) · Waldemer Carlo, M.D. (1) · Yi Ji (1)
PMID 24252784, PMID 30542204, PMID 32894644, PMID 37264205, PMID 40102890, PMID 41297007
2025 (1)