5 completed, 1 active not recruiting, 1 not yet recruiting, 1 recruiting. 2 Not applicable, 2 Phase 1, 2 Phase 2, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 2 | Completed 2 |
| Phase 1 | 2 | Completed 2 |
| Phase 2 | 2 | Active not recruiting 1, Withdrawn 1 |
| Early Phase 1 | 1 | Not yet recruiting 1 |
Follow Cancer, Advanced: new trials by email Literature Review of Cancer, Advanced trials Research Report on Cancer, Advanced
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Azoles Targeting Recurrent High Grade Gliomas Ketoconazole (KCZ), Posaconazole (PCZ) - Brain Tumor, Recurrent, Cancer, Advanced | Early Phase 1 | Not yet recruiting | University Health Network, Toronto | 30 | 2024-06-01 | 2024-03-08 |
| Study of a Behavioral Intervention for Older Advanced Cancer Patients and Their Caregivers Dyadic Life Review (DLR) - Cancer, Advanced, Cognitive Impairment, Mild | Not applicable | Completed | University of Rochester | 38 | 2022-03-28 | 2025-11-25 |
| The Registry of Oncology Outcomes Associated With Testing and Treatment Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P) - Adenocarcinoma, Adenocystic Carcinoma | Completed | Taproot Health | 167 | 2021-05-05 | 2024-12-18 | |
| The Integrated Support and Palliative in Cancer Day-care Hospital for Patients With Advanced Cancers: Impact on Quality of Life, Care Pathways and Support for Caregivers (HDJ-SPI) Hospital day care follow-up - Cancer, Advanced | Not applicable | Completed | Institut Curie | 144 | 2020-09-28 | 2025-09-19 |
| The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology) Cancer, All Types, Cancer of Liver | Unknown | SpeciCare | 1000 | 2019-03-21 | 2020-12-04 | |
| Histology-Independent Study of Palbociclib in Patients With Advanced Cancer Palbociclib 125mg - Cancer, Advanced | Phase 2 | Withdrawn | Razelle Kurzrock, MD | 2018-07-01 | 2018-06-21 | |
| Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer Pembrolizumab, Radiation therapy, Cisplatin - Head and Neck Squamous Cell Carcinoma, Cancer | Phase 2 | Active not recruiting | Loren Mell, MD | 126 | 2018-03-15 | 2025-10-07 |
| SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry Clinical Trial Matching - Cancer, Metastatic, Cancer | Recruiting | Massive Bio, Inc. | 50000 | 2018-01-01 | 2025-10-28 | |
| Pharmacokinetics of Ridaforolimus (MK-8669) in Chinese Participants (MK-8669-059) ridaforolimus - Cancer, Advanced | Phase 1 | Completed | Merck Sharp & Dohme LLC | 15 | 2011-07-05 | 2019-04-19 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MK0683 in Patients With Advanced Cancer (0683-008) vorinostat (MK0683 ) - Cancer, Advanced | Phase 1 | Completed | Merck Sharp & Dohme LLC | 30 | 2004-11-01 | 2017-04-07 |
Neoplasms (10) · Head and Neck Neoplasms (4) · Brain Neoplasms (3) · Breast Neoplasms (3) · Cholangiocarcinoma (3) · Colonic Neoplasms (3) · Esophageal Neoplasms (3) · Glioblastoma (3) · Kidney Neoplasms (3) · Laryngeal Neoplasms (3) · Liver Neoplasms (3) · Lung Neoplasms (3) · Melanoma (3) · Neoplasm Metastasis (3) · Pancreatic Neoplasms (3)
Neoplasms by Histologic Type (5) · Neoplasms by Site (5) · Neoplasms, Glandular and Epithelial (5) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Neoplasms, Germ Cell and Embryonal (4) · Neoplasms, Nerve Tissue (4) · Neoplasms, Neuroepithelial (4) · Neoplastic Processes (4) · Nervous System Diseases (4) · Nervous System Neoplasms (4) · Neuroectodermal Tumors (4) · Otorhinolaryngologic Diseases (4) · Otorhinolaryngologic Neoplasms (4) · Brain Diseases (3)
Drug Therapy (2) · Immunotherapy (2) · Biological Therapy (1) · Cisplatin (1) · Ketoconazole (1) · Molecular Diagnostic Techniques (1) · Patient Reported Outcome Measures (1) · Quality of Life (1) · Radiotherapy (1) · Vorinostat (1) · palbociclib (1) · pembrolizumab (1) · posaconazole (1) · ridaforolimus (1)
Merck Sharp & Dohme LLC (2) · Institut Curie (1) · Loren Mell, MD (1) · Massive Bio, Inc. (1) · Razelle Kurzrock, MD (1) · SpeciCare (1) · Taproot Health (1) · University Health Network, Toronto (1) · University of Rochester (1)
United States (6) · Canada (1) · France (1) · Puerto Rico (1)
Gelareh Zadeh, MD, PhD (1) · Jennifer Johnson, MD, PhD (1) · Ken Dixon, MD (1) · Loren Mell, MD (1) · Raymond Bergan, MD (1) · Razelle Kurzrock, MD (1) · Scott Lippman, MD (1) · Selin Kurnaz, PhD (1) · Vivek Subbiah, MD (1)
PMID 17145826, PMID 23829943, PMID 29149611, PMID 33865379
P30AG064103 (1), T32CA102618 (1)