6 completed, 3 not yet recruiting, 3 unknown, 1 active not recruiting. 10 Not applicable, 3 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 4, Not yet recruiting 3, Unknown 2, Active not recruiting 1 |
| Phase 4 | 3 | Completed 2, Recruiting 1 |
Follow Caloric Restriction: new trials by email Literature Review of Caloric Restriction trials Research Report on Caloric Restriction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Long-Term Effects of Semaglutide on Body Composition and Performance in Running Semaglutide (SEMA), Placebo - Caloric Restriction, Body Composition | Not applicable | Not yet recruiting | Morten Hostrup, PhD | 41 | 2026-10-14 | 2026-10-15 |
| Short Term Effects of Semaglutide on Body Composition and Performance Semaglutide (SEMA), Placebo - Caloric Restriction, Body Composition | Not applicable | Not yet recruiting | Morten Hostrup, PhD | 41 | 2026-10-14 | 2026-10-15 |
| BRAHMS: Bed Rest And HypoMetabolism Study head down bedrest and caloric restriction - Microgravity, Caloric Restriction | Not applicable | Active not recruiting | Centre National d'Etudes Spatiales | 10 | 2026-03-10 | 2026-07-10 |
| The Effect of Ketogenic-caloric Restricted Diet on Metabolic Endotoxemia in Prediabetic Obese Adults Ketogenic diet with caloric restriction, Normal diet with caloric restriction, Normal diet without caloric restriction - Insulin Resistance, Metabolic Endotoxemia | Not applicable | Completed | University of Jordan | 90 | 2025-05-05 | 2026-05-05 |
| The Effect of Time Restricted Eating on Glycemic and Proinflammatory Biomarkers Among Prediabetic Obese Jordanian Adults Aged 18-40 Years Old time restricted eating with caloric restriction, time restricted eating without caloric restriction, Caloric restriction without Time restricted eating - Insulin Resistance, Inflammation Biomarkers | Not applicable | Not yet recruiting | University of Jordan | 120 | 2025-04-05 | 2025-04-04 |
| The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes semaglutide, caloric restriction - Type 2 Diabetes Mellitus (T2DM), Semaglutide | Phase 4 | Recruiting | Second Affiliated Hospital of Nanchang University | 100 | 2023-02-10 | 2026-04-02 |
| Intermittent Fasting (IF) Has Gained Recognition as a Promising Weight Loss Approach That Improves Body Weight, Insulin Resistance, and Metabolism. While Standard Diets Are Common in PCOS Management, IF May Address the Underlying Causes of Weight Gain and Offer Additional Metabolic Benefits Intermittent Fasting, Standart Diet Therapy - Polycystic Ovary Syndrome, Weight Loss | Not applicable | Completed | Bahçeşehir University | 33 | 2022-11-30 | 2025-01-31 |
| Calorie Restriction in Multiple Sclerosis Caloric restriction, Caloric restriction without cow's milk and gluten - Multiple Sclerosis, Relapsing-Remitting, Caloric Restriction | Not applicable | Unknown | Federico II University | 93 | 2020-07-14 | 2024-08-20 |
| Trial of Testosterone Undecanoate for Optimizing Performance During Military Operations Testosterone Undecanoate, Sesame Oil - Caloric Restriction, Exercise | Phase 4 | Completed | Pennington Biomedical Research Center | 34 | 2019-09-23 | 2022-10-07 |
| Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females Ketone supplementation, Increased protein intake - Muscle Wasting, Protein Intake | Not applicable | Completed | KU Leuven | 44 | 2018-01-01 | 2021-02-08 |
| Short-Term Endogenous Hydrogen Sulfide Upregulation ScandiShake - Carotid Stenosis, Caloric Restriction | Not applicable | Completed | Brigham and Women's Hospital | 9 | 2017-09-14 | 2018-06-28 |
| Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery Sesame Oil, testosterone enanthate - Caloric Restriction, Exercise | Phase 4 | Completed | Pennington Biomedical Research Center | 53 | 2016-04-01 | 2019-01-16 |
| An Early-customized Low Glycaemic-index (GI) Diet Prevents LGA Babies in Overweight/Obese Pregnant Women Low-glycemic index group, Standard Care Group - Maternal Obesity Complicating Pregnancy, Birth,or Puerperium, Gestational Diabetes Mellitus | Not applicable | Unknown | University of Modena and Reggio Emilia | 100 | 2015-12-01 | 2016-04-26 |
| A New Method for Self-assessment of Daily Calorie Intake Diet Records, Caloric Restriction | Unknown | Assuta Hospital Systems | 135 | 2011-07-01 | 2012-05-01 |
Inflammation (3) · Obesity (3) · Insulin Resistance (2) · Intermittent Fasting (2) · Motor Activity (2) · Weight Loss (2) · Birth Weight (1) · Carotid Stenosis (1) · Diabetes Mellitus, Type 2 (1) · Diabetes, Gestational (1) · Ketosis (1) · Multiple Sclerosis (1) · Multiple Sclerosis, Relapsing-Remitting (1) · Muscular Atrophy (1) · Overweight (1)
Pathological Conditions, Signs and Symptoms (8) · Nutritional and Metabolic Diseases (6) · Signs and Symptoms (6) · Body Weight (5) · Metabolic Diseases (5) · Behavior (4) · Endocrine System Diseases (4) · Glucose Metabolism Disorders (4) · Diabetes Mellitus (3) · Nervous System Diseases (3) · Nutrition Disorders (3) · Overnutrition (3) · Pathologic Processes (3) · Body Weight Changes (2) · Fasting (2)
Caloric Restriction (5) · semaglutide (3) · Sesame Oil (2) · Diet, Ketogenic (1) · Glutens (1) · Milk (1) · Testosterone Propionate (1) · testosterone enanthate (1) · testosterone undecanoate (1)
Morten Hostrup, PhD (2) · Pennington Biomedical Research Center (2) · University of Jordan (2) · Assuta Hospital Systems (1) · Bahçeşehir University (1) · Brigham and Women's Hospital (1) · Centre National d'Etudes Spatiales (1) · Federico II University (1) · KU Leuven (1) · Second Affiliated Hospital of Nanchang University (1) · University of Modena and Reggio Emilia (1)
United States (3) · Denmark (2) · Italy (2) · Jordan (2) · Belgium (1) · China (1) · France (1) · Israel (1) · Turkey (Türkiye) (1)
C. Keith Ozaki, M.D. (1) · Jennifer C Rood, Ph.D. (1) · Jennifer C Rood, PhD (1) · Katrien Koppo, PhD (1) · Orit Klinger, MD (1)
PMID 12531880, PMID 15788534, PMID 16410832, PMID 28479217, PMID 29044230, PMID 31894236, PMID 32258956, PMID 34278044, PMID 35532889, PMID 36481265, PMID 36563086, PMID 36796647, PMID 36949577, PMID 40279652, PMID 41747400