5 completed, 4 terminated, 3 recruiting, 1 active not recruiting. 14 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 14 | Completed 5, Terminated 4, Recruiting 3, Active not recruiting 1, Not yet recruiting 1 |
Follow Brain Tumor: new trials by email Literature Review of Brain Tumor trials Research Report on Brain Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Asciminib With or Without Sildenafil for Brain Tumors Asciminib, Sildenafil, Surgical resection or biopsy - Brain Tumor | Early Phase 1 | Not yet recruiting | Washington University School of Medicine | 12 | 2026-10-31 | 2026-09-11 |
| A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma Troriluzole - Glioblastoma, Recurrent Glioblastoma | Early Phase 1 | Recruiting | Ugonma Chukwueke | 27 | 2025-02-19 | 2025-09-11 |
| 68Ga-RM26-RGD PET/CT Imaging in the GRPR and αvβ3 Positive Tumor Patients 68Ga-RM26-RGD, 18F-FDG, 68Ga-RM26 - Breast Cancer, Prostate Cancer | Early Phase 1 | Recruiting | Peking Union Medical College Hospital | 90 | 2022-08-16 | 2024-07-05 |
| Tolerability and Activity of Brivaracetam (BRV) in Patients With Diffuse Gliomas Brivaracetam - Brain Tumor | Early Phase 1 | Terminated | University of Rochester | 3 | 2022-05-17 | 2026-06-03 |
| Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MR 18F-FTX - Brain Tumor, Cervical Cancer | Early Phase 1 | Active not recruiting | M.D. Anderson Cancer Center | 20 | 2021-09-20 | 2026-10-08 |
| Abemaciclib w/Bevacizumab in Recurrent GBM Pts w/Loss of CDKN2A/B or Gain or Amplification of CDK4/6 Abemaciclib, Bevacizumab - GBM, Glioblastoma | Early Phase 1 | Terminated | University of Texas Southwestern Medical Center | 10 | 2019-12-13 | 2025-08-17 |
| PET and MRI Imaging of Brain Tumors Using [18F]PARPi PET/MR with [18F]PARPi, [18F]PARPi - Brain Tumor, Brain Cancer | Early Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 5 | 2019-11-01 | 2026-02-09 |
| Study of Letrozole in Recurrent Gliomas Letrozole Oral Tablet, Temozolomide - Brain Tumor | Early Phase 1 | Recruiting | University of Cincinnati | 39 | 2017-05-16 | 2026-08-18 |
| Feasibility Trial of the Modified Atkins Diet and Bevacizumab for Recurrent Glioblastoma Bevacizumab, Modified Atkins Diet - Glioblastoma, Brain Tumor | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 18 | 2016-09-06 | 2019-03-15 |
| Topotecan in Glioma Undergoing A Clinically-Indicated Surgical Resection topotecan, Cleveland Multiport Catheter - Brain Tumor, High Grade Glioma | Early Phase 1 | Terminated | Michael Vogelbaum, MD, PhD | 9 | 2015-07-06 | 2019-03-01 |
| Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study Ommaya Reservoir, Methotrexate, Leucovorin - Brain Tumor, Malignant Neoplasm of Fourth Ventricle of Brain | Early Phase 1 | Completed | M.D. Anderson Cancer Center | 7 | 2012-12-27 | 2018-01-19 |
| Radiosurgery Plus Bevacizumab in Glioblastoma radiosurgery, bevacizumab, irinotecan hydrochloride - Glioblastoma, Gliosarcoma | Early Phase 1 | Terminated | Case Comprehensive Cancer Center | 9 | 2010-02-01 | 2018-07-03 |
| Sunitinib Tumor Levels in Patients Not on Enzyme-Inducing Anti-Epileptic Drugs Undergoing Debulking Surgery for Recurrent Glioblastoma Sunitinib - Glioblastoma, Brain Tumor | Early Phase 1 | Completed | Massachusetts General Hospital | 8 | 2007-05-01 | 2016-07-07 |
| A Study of Therapeutic Amplitude-modulated Electromagnetic Fields in Advanced Tumors Low levels of amplitude-modulated electromagnetic fields, Emitter of low levels of amplitude-modulated electromagnetic fields - Cancer, Brain Tumor | Early Phase 1 | Completed | Pasche, Boris, M.D. | 2 | 2004-10-01 | 2011-06-29 |
Brain Neoplasms (14) · Glioblastoma (5) · Neoplasms (2) · Breast Neoplasms (1) · Ependymoma (1) · Epilepsy (1) · Glioma (1) · Gliosarcoma (1) · Medulloblastoma (1) · Prostatic Neoplasms (1) · Rhabdoid Tumor (1) · Uterine Cervical Neoplasms (1)
Brain Diseases (14) · Central Nervous System Diseases (14) · Central Nervous System Neoplasms (14) · Neoplasms by Site (14) · Nervous System Diseases (14) · Nervous System Neoplasms (14) · Neoplasms (12) · Neoplasms by Histologic Type (7) · Neoplasms, Germ Cell and Embryonal (7) · Neoplasms, Glandular and Epithelial (7) · Neoplasms, Nerve Tissue (7) · Neoplasms, Neuroepithelial (7) · Neuroectodermal Tumors (7) · Glioma (6) · Astrocytoma (5)
Bevacizumab (3) · 68Ga-NOTA-RM26 (1) · Biopsy (1) · Fluorodeoxyglucose F18 (1) · Irinotecan (1) · Letrozole (1) · Leucovorin (1) · Methotrexate (1) · Radiosurgery (1) · Sildenafil Citrate (1) · Sunitinib (1) · Temozolomide (1) · Topotecan (1) · abemaciclib (1) · asciminib (1)
Case Comprehensive Cancer Center (2) · M.D. Anderson Cancer Center (2) · Massachusetts General Hospital (1) · Memorial Sloan Kettering Cancer Center (1) · Michael Vogelbaum, MD, PhD (1) · Pasche, Boris, M.D. (1) · Peking Union Medical College Hospital (1) · Ugonma Chukwueke (1) · University of Cincinnati (1) · University of Rochester (1) · University of Texas Southwestern Medical Center (1) · Washington University School of Medicine (1)
United States (12) · China (1) · Switzerland (1)
Boris C Pasche, MD, PhD (1) · Caroline Chung (1) · David Sandberg, MD (1) · Eric Thompson, M.D. (1) · Lalanthica Yogendran, MD (1) · Lisa Rogers, DO (1) · Michael A Vogelbaum, MD, PhD (1) · Michael Vogelbaum, MD (1) · Robert Young, MD (1) · Scott Plotkin, MD, PhD (1) · Soumen Khatua, MD (1) · Ugonma Chukwueke, MD (1) · Zhaohui Zhu, MD,PHD (1)