10 completed, 9 recruiting, 5 unknown, 4 not yet recruiting. 11 Not applicable, 4 Phase 1, 4 Phase 2, 2 Phase 3, 1 Early Phase 1.
Follow Brain Tumor, Primary: new trials by email Literature Review of Brain Tumor, Primary trials Research Report on Brain Tumor, Primary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating Biomarkers of Cognitive Dysfunction in Patients With Cancer Blood sample, Brain magnetic resonance imaging (MRI), Brain Health Assessment - Brain Tumor Adult, Brain Metastases From Solid Tumors | Not yet recruiting | University of California, San Francisco | 40 | 2026-12-15 | 2026-10-29 | |
| Correlation Between Nutritional Status of Childhood Neurological Tumors and Quality of Life Nutritional Status, Quality of Life | Not yet recruiting | Nanfang Hospital, Southern Medical University | 93 | 2025-12-15 | 2025-12-16 | |
| Neurofeedback and Cognitive Training for PBTS neurofeedback, Cognitive Training, Sham feedback - Brain Tumor, Primary | Not applicable | Enrolling by invitation | The University of Hong Kong | 50 | 2025-08-01 | 2026-01-27 |
| 3D Decision Support Tool for Brain Tumour Surgery Development and Validation: Observational Study Brain (Nervous System) Cancers, Brain Tumor, Primary | Not yet recruiting | Fundación Canaria Instituto de Investigación Sanitaria de Canarias | 320 | 2025-07-01 | 2025-06-25 | |
| Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy Focused Ultrasound Next Generation Dome Helmet, Definity® Vial for (Perflutren Lipid Microsphere) Injectable Suspension - GBM, Glioblastoma Multiforme (GBM) | Phase 1 | Recruiting | Sunnybrook Health Sciences Centre | 10 | 2025-06-04 | 2025-09-17 |
| Research on the Safety and Efficacy of Intraoperative Radiation Therapy in Malignant Cerebral Tumor Intraoperative Radiation Therapy in Malignant Cerebral Tumor - Glioblastoma, Brain Tumor, Primary | Not applicable | Not yet recruiting | First Affiliated Hospital, Sun Yat-Sen University | 200 | 2025-06-01 | 2025-04-16 |
| Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent RVP-001 - Central Nervous System (CNS) Lesions, Brain Metastases | Phase 2 | Completed | Reveal Pharmaceuticals Inc. | 18 | 2024-08-15 | 2025-12-26 |
| Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients Cognitive testing, Resting State MRI/Precision functional mapping - Brain Tumor, Primary | Recruiting | Washington University School of Medicine | 16 | 2024-07-10 | 2026-07-17 | |
| Clinical Feasibility of Brain Radiotherapy Using Synthetic CTs in an MRI-only Workflow brain radiotherapy - Brain Tumor, Primary, Brain Tumor - Metastatic | Not applicable | Unknown | University of Erlangen-Nürnberg Medical School | 54 | 2024-01-01 | 2023-10-30 |
| FeelFit: High-intensity Interval Training to Improve Self-reported Physical Fitness in Brain Tumor Patients High-Intensity Interval Training (HIIT) - Brain Tumor, Primary, Exercise | Not applicable | Recruiting | Amsterdam UMC, location VUmc | 36 | 2024-01-01 | 2025-04-06 |
| Performance of Elucirem in DSC-MRI Perfusion of Brain Gliomas Elucirem, Dotarem - Brain Tumor, Primary, Brain Tumor, Recurrent | Phase 3 | Completed | Guerbet | 138 | 2023-09-07 | 2026-01-29 |
| Circulating Biomarkers Repository in Adults Diagnosed With Primary and Metastatic Brain Tumors Brain Tumor, Primary, Brain Metastases, Adult | Recruiting | Duke University | 300 | 2022-12-01 | 2026-10-20 | |
| Characterization of Circulating and Tumor-infiltrating Immune Cells in Malignant Brain Tumors Circulating leukocytes immunophenotype, Tumor sampling - Brain Tumor, Primary, Brain Tumor - Metastatic | Recruiting | Pietro Mortini, MD, Prof. | 200 | 2022-08-01 | 2025-06-11 | |
| Multimodality MRI and Liquid Biopsy in GBM Post Feraheme Infusion MRI - Glioblastoma Multiforme, Brain Tumor, Adult: Glioblastoma | Early Phase 1 | Withdrawn | Abramson Cancer Center at Penn Medicine | 2022-06-01 | 2022-09-16 | |
| The Efficacy of HLX208 (BRAF V600E Inhibitor) for Refractory Primary Brain Tumors With BRAF Mutation After First-line Treatment HLX208 - Brain Tumor, Primary | Phase 2 | Unknown | Shanghai Henlius Biotech | 40 | 2021-12-23 | 2022-05-03 |
| Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors PBI-200 - Solid Tumor, Adult, Brain Tumor, Primary | Phase 1 | Terminated | Pyramid Biosciences | 29 | 2021-07-20 | 2024-03-28 |
| A Tailored Exercise Oncology Program for Neuro-Oncology Patients Tailored Exercise Intervention - Cancer, Brain Tumor, Primary | Not applicable | Unknown | University of Calgary | 70 | 2021-04-15 | 2023-01-18 |
| Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles) GammaTile - Brain Tumor, Recurrent, Brain Tumor | Recruiting | GT Medical Technologies, Inc. | 600 | 2020-09-11 | 2026-07-22 | |
| Glutamate Excitotoxicity and Its Role in Glioblastoma Biology Blood, CSF and tumor samples - Brain Tumor, Primary | Recruiting | IRCCS San Raffaele | 50 | 2020-06-01 | 2025-06-11 | |
| Ultrasound Elastography and Ultrasentive Doppler for Surgery of Brain Tumors brain tumor resection - Brain Tumor, Primary | Not applicable | Completed | University Hospital, Tours | 20 | 2019-04-15 | 2023-12-05 |
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Brain Neoplasms (33) · Glioblastoma (6) · Glioma (6) · Neoplasms (4) · Meningioma (3) · Motor Activity (2) · Neurilemmoma (2) · Central Nervous System Neoplasms (1) · Cognitive Dysfunction (1) · Desmoplastic Small Round Cell Tumor (1) · Lymphoma, Follicular (1) · Multiple Sclerosis (1) · Neurofibroma (1) · Neuroinflammatory Diseases (1) · Neurologic Manifestations (1)
Brain Diseases (33) · Central Nervous System Diseases (33) · Neoplasms by Site (33) · Nervous System Diseases (33) · Nervous System Neoplasms (33) · Central Nervous System Neoplasms (32) · Neoplasms (29) · Neoplasms by Histologic Type (12) · Neoplasms, Nerve Tissue (11) · Neoplasms, Germ Cell and Embryonal (10) · Neuroectodermal Tumors (10) · Neoplasms, Glandular and Epithelial (9) · Neoplasms, Neuroepithelial (9) · Astrocytoma (6) · Glioma (3)
Aminolevulinic Acid (2) · Blood Specimen Collection (2) · Capecitabine (1) · Cognitive Training (1) · Diffusion Tensor Imaging (1) · HES 130-0.4 (1) · High-Intensity Interval Training (1) · Indocyanine Green (1) · Mn-PyC3A (1) · Neurofeedback (1) · Neuropsychological Tests (1) · Quality of Life (1) · Surveys and Questionnaires (1) · Temozolomide (1) · gadopiclenol (1)
Duke University (2) · Abramson Cancer Center at Penn Medicine (1) · Amsterdam UMC, location VUmc (1) · Constantinos Hadjipanayis (1) · Elisabeth-TweeSteden Ziekenhuis (1) · First Affiliated Hospital, Sun Yat-Sen University (1) · Fundación Canaria Instituto de Investigación Sanitaria de Canarias (1) · GT Medical Technologies, Inc. (1) · Guerbet (1) · IRCCS San Raffaele (1) · Nanfang Hospital, Southern Medical University (1) · National Cancer Institute (NCI) (1) · National Taiwan University Hospital (1) · Northwell Health (1) · Pietro Mortini, MD, Prof. (1)
United States (13) · Italy (4) · Canada (2) · France (2) · Germany (2) · Hong Kong (2) · Netherlands (2) · South Korea (2) · United Kingdom (2) · Australia (1) · China (1) · Denmark (1) · Hungary (1) · India (1) · Poland (1)
Pietro Mortini, MD, Prof. (2) · Abdul R Bhat, MCh (1) · Alfonso Lagares, MD, PhD (1) · Ashlee Loughan, PhD (1) · Carl Koschmann, M.D. (1) · Christoph Bert, Prof. Dr. rer. nat (1) · Chul-Kee Park, MD PhD (1) · Chun-Yu Wu, MD (1) · Costas Hadjipanayis, MD, PhD (1) · Eugene Vaios, MD MBA (1) · Florian Putz, PD Dr. med. (1) · Frantz Hebert (1) · Gloria Roldan Urgoiti, MD (1)
PMID 16648043, PMID 25304271, PMID 25876221, PMID 26516822, PMID 26815631, PMID 27178235, PMID 27585837, PMID 28161011, PMID 28981592, PMID 30215565, PMID 31482242, PMID 31832214, PMID 33068429, PMID 34491526, PMID 38459584, PMID 39917754, PMID 41702662, PMID 42684658
R01CA176659 (1), R21CA186169 (1), R44CA261240 (1)