23 recruiting, 11 completed, 9 active not recruiting, 7 unknown. 22 Phase 2, 16 Not applicable, 7 Phase 1, 1 Early Phase 1, 1 Phase 3.
Follow Brain Metastases, Adult: new trials by email Literature Review of Brain Metastases, Adult trials Research Report on Brain Metastases, Adult
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study Comparing Neoadjuvant Versus Adjuvant Stereotactic Radiotherapy of Brain Metastases stereotactic radiotherapy, Excision surgery - Brain Metastases, Adult | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 68 | 2026-09-01 | 2026-08-25 |
| Tarlatamab for SCLC Brain Metastases Tarlatamab - Small Cell Lung Cancer, Brain Metastases, Adult | Phase 2 | Recruiting | Maastricht University Medical Center | 35 | 2026-08-01 | 2026-07-31 |
| BEAT-Breast: Trial of DE-iPTV in Patients With Primary Breast Cancer With Brain Metastases Who Are Not Suitable for Stereotactic Radiotherapy. DE-iPTV - Brain Metastases, Adult, Breast Cancer | Not applicable | Recruiting | Imperial College London | 42 | 2026-06-01 | 2026-10-08 |
| Local Treatment Strategies for Brain Metastases of Colorectal Cancer Neurosurgical Resection (NRS): En-bloc (EBR), Total piecemeal (TPR), Subtotal (SPR) or Partial (PPR), Radiotherapy (RT): Stereotactic Radiosurgery/Radiotherapy (SRS/SRT), Whole-Brain Radiotherapy (WBRT), Combined Local Treatment Modalities - Colorectal Cancer, Brain Metastases, Adult | Active not recruiting | Blokhin's Russian Cancer Research Center | 700 | 2026-02-01 | 2026-03-04 | |
| Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction Linear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV - Brain Metastases, Adult, Brain Tumor - Metastatic | Phase 2 | Recruiting | Ayal A. Aizer, MD | 60 | 2025-12-30 | 2026-09-08 |
| Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases Levetiracetam (Keppra) - Seizures, Primary Motor Cortex | Phase 2 | Recruiting | Ayal A. Aizer, MD | 150 | 2025-12-23 | 2026-09-08 |
| Ex Vivo Drug Response Evaluation for Next Generation Care of Brain Metastases Pharmacoscopy 1.0, Control - Brain Metastases, Brain Metastases, Adult | Phase 2 | Recruiting | University of Zurich | 102 | 2025-09-12 | 2026-06-29 |
| AI-assisted Diagnosis of Malignant Brain Tumors Gliomas, Brain Metastases, Adult | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 3000 | 2025-09-01 | 2025-09-30 | |
| A Window of Opportunity Study of Patritumab Deruxtecan in Patients With Brain Metastases Patritumab deruxtecan - Brain Metastases, Adult | Phase 2 | Withdrawn | Mustafa Khasraw, MBChB, MD, FRCP, FRACP | 2025-07-01 | 2025-06-15 | |
| Avoiding Radiation Therapy Due to Intracranial Response to Chemotherapy, Targeted Therapy and/or Immuno-ONcology Therapy for Brain Metastases: Pilot Pragmatic Trial Active Surveillance - Brain Metastases, Adult, Brain Metastases From Non-small Cell Lung Cancer (NSCLC) | Phase 2 | Recruiting | University of Vermont Medical Center | 45 | 2025-06-05 | 2026-05-26 |
| Sacituzumab Govitecan and Bevacizumab for NSCLC Brain Metastases Sacituzumab Govitecan-Hziy 180 MG plus bevacizumab - NSCLC Stage IV, Brain Metastases, Adult | Phase 2 | Recruiting | Maastricht University Medical Center | 25 | 2025-04-24 | 2025-05-06 |
| JDQ443 for KRAS G12C NSCLC Brain Metastases JDQ443 - Non Small Cell Lung Cancer Metastatic, Brain Metastases, Adult | Phase 2 | Withdrawn | Maastricht University Medical Center | 2024-04-15 | 2024-05-29 | |
| 18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery 18F fluciclovine - Brain Metastases, Brain Metastases, Adult | Phase 1 | Recruiting | Baptist Health South Florida | 46 | 2024-04-11 | 2026-05-20 |
| Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer Tumor samples will be tested for mutation status of KRAS, NRAS, BRAF, HER2 and MSI - Colorectal Cancer Metastatic, Brain Metastases, Adult | Recruiting | Blokhin's Russian Cancer Research Center | 30 | 2024-04-01 | 2026-10-05 | |
| a Feasibility Study of iHD-SRT for BM iHD-SRT - Brain Metastases, Adult, Stereotactic Radiotherapy | Not applicable | Recruiting | Ruijin Hospital | 35 | 2024-03-15 | 2024-04-10 |
| A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors 68Ga-PSMA-11 PET Scans - High-grade Glioma, Brain Metastases | Early Phase 1 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 11 | 2024-01-05 | 2025-12-03 |
| Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases Azeliragon, Stereotactic radiosurgery, Corticosteroid - Cancer, Metastasis | Phase 1 / Phase 2 | Suspended | Baptist Health South Florida | 46 | 2023-11-17 | 2026-06-16 |
| Multi-disciplinary Care for Brain Metastases health services intervention - Brain Metastases, Adult | Not applicable | Recruiting | University of Vermont Medical Center | 40 | 2023-11-16 | 2026-01-29 |
| Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis NEO212 Oral Capsule, Ipilimumab, Pembrolizumab - Diffuse Astrocytoma, IDH-Mutant, Glioblastoma, IDH-wildtype | Phase 1 / Phase 2 | Recruiting | Neonc Technologies, Inc. | 134 | 2023-11-01 | 2026-09-24 |
| SILibinin in NSCLC and BC Patients With Single Brain METastasis (SILMET) Silibinin, Placebo - Brain Metastases, Adult, Non Small Cell Lung Cancer | Not applicable | Recruiting | A.O.U. Città della Salute e della Scienza | 70 | 2023-09-01 | 2023-12-15 |
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Brain Neoplasms (60) · Carcinoma, Non-Small-Cell Lung (8) · Small Cell Lung Carcinoma (6) · Breast Neoplasms (5) · Melanoma (5) · Carcinoma, Renal Cell (4) · Neoplasms (4) · Carcinoma, Transitional Cell (3) · Glioma (3) · Lung Neoplasms (3) · Carcinoma, Merkel Cell (2) · Colorectal Neoplasms (2) · Esophageal Neoplasms (2) · Neoplasm Metastasis (2) · Stomach Neoplasms (2)
Brain Diseases (60) · Central Nervous System Diseases (60) · Neoplasms by Site (60) · Nervous System Diseases (60) · Nervous System Neoplasms (60) · Central Nervous System Neoplasms (59) · Neoplasms (56) · Respiratory Tract Diseases (12) · Respiratory Tract Neoplasms (12) · Thoracic Neoplasms (12) · Bronchial Neoplasms (11) · Carcinoma, Bronchogenic (11) · Lung Diseases (11) · Lung Neoplasms (9) · Neoplasms by Histologic Type (9)
Radiosurgery (9) · Nivolumab (4) · Carboplatin (3) · Ipilimumab (3) · Paclitaxel (3) · Bevacizumab (2) · Cisplatin (2) · Silybin (2) · fluciclovine F-18 (2) · pembrolizumab (2) · 130-nm albumin-bound paclitaxel (1) · AGuIX (1) · Adrenal Cortex Hormones (1) · Blood Specimen Collection (1) · Capecitabine (1)
Duke University (4) · Baptist Health South Florida (3) · Maastricht University Medical Center (3) · Memorial Sloan Kettering Cancer Center (3) · Ayal A. Aizer, MD (2) · Blokhin's Russian Cancer Research Center (2) · Istituto Clinico Humanitas (2) · University of Vermont Medical Center (2) · A.O.U. Città della Salute e della Scienza (1) · AC Camargo Cancer Center (1) · AHS Cancer Control Alberta (1) · Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) (1) · British Columbia Cancer Agency (1) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (1) · Centre de recherche du Centre hospitalier universitaire de Sherbrooke (1)
United States (25) · Canada (5) · Italy (4) · Netherlands (4) · China (3) · France (3) · Switzerland (3) · Austria (2) · Germany (2) · Russia (2) · Belarus (1) · Belgium (1) · Brazil (1) · Denmark (1) · India (1)
Alexey Tryakin, MD, professor (2) · Ali Bekyashev, MD, professor (2) · Ayal A Aizer, MD, MHS (2) · Lizza Hendriks, MD, PhD (2) · Alan Nichol, MD (1) · An Nulens (1) · Anna Stroganova, MD (1) · Anton Nosov, MD (1) · Ashlee Loughan, PhD (1) · Budhi Singh Yadav, MD (1) · Catherine Coolens, Ph. D (1) · Colette Shen, M.D., Ph.D (1) · David Khalafyan, MD (1) · Deborah Allen, PhD (1)
PMID 29528419, PMID 31852497, PMID 34081125, PMID 34934856, PMID 40110068, PMID 40720079, PMID 40983872
2023 (1), 2025 (1), 5UG1CA189824-08 (1), R01CA238783 (1)