11 completed, 3 terminated, 2 unknown, 2 withdrawn. 7 Phase 2, 5 Not applicable, 4 Phase 4, 3 Phase 3, 2 Phase 1.
Follow Silybin: new trials by email Literature Review of Silybin trials Research Report on Silybin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Silibinin in Association With Concomitant Chemoradiotherapy and Maintenance Temozolomide in STAT3 Positive IDH Wild-type, Newly Diagnosed Glioblastoma Patients Silibinin as STAT3 inhibitor, Placebo - Glioblastoma, IDH Wild-type and STAT3-positive Glioblastoma | Not applicable | Withdrawn | Istituto Oncologico Veneto IRCCS | 2025-11-12 | 2026-10-02 | |
| SILibinin in NSCLC and BC Patients With Single Brain METastasis (SILMET) Silibinin, Placebo - Brain Metastases, Adult, Non Small Cell Lung Cancer | Not applicable | Recruiting | A.O.U. Città della Salute e della Scienza | 70 | 2023-09-01 | 2023-12-15 |
| Prospective Double Arm Randomized Trial: WBRT Alone and WBRT Plus Silibinin Silibinin - Brain Metastases, Adult | Not applicable | Active not recruiting | Istituto Clinico Humanitas | 44 | 2023-03-06 | 2025-04-24 |
| Effect of L-ornithine-L-aspertate (LOLA) on the Gut Microbiome L-ornithine L-aspartate - Cirrhosis | Phase 4 | Completed | Medical University of Graz | 52 | 2023-02-06 | 2026-10-09 |
| Effect of Silibinin(A) as a Potential Anti-obesity Agent Silibinin A - Overweight and Obesity, Hypercholesterolemia | Not applicable | Unknown | Universidad Católica San Antonio de Murcia | 60 | 2023-01-12 | 2023-06-23 |
| An Intervention Study of Compound Silymarin in Patients With Non-alcoholic Fatty Liver Disease Silibinin extract, mixed power of pueraria, schisandra and salvia miltiorrhiza, Silibinin extract, Placebo - Nonalcoholic Fatty Liver Disease | Not applicable | Completed | Guangzhou Medical University | 94 | 2022-08-01 | 2024-02-28 |
| Silymarin Cream Versus Salicylic Acid in Treatment of Acne Vulgaris Silymarin, Salicylic acid - Acne Vulgaris | Phase 4 | Unknown | Assiut University | 30 | 2021-04-01 | 2021-03-12 |
| Silymarin in COVID-19 Patients Admitted to Hospital With Elevated Liver Enzymes Silymarin - Covid19, Liver Diseases | Phase 4 | Completed | F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica | 30 | 2021-03-17 | 2022-08-03 |
| Trial of Indole-3-Carbinol and Silibinin Indole-3-Carbinol, Silibinin, Silibin - Smoking | Phase 1 | Completed | Masonic Cancer Center, University of Minnesota | 21 | 2018-11-29 | 2021-08-11 |
| Effects of Silybin in Hypertensive Patients Silybin - Hypertension | Phase 4 | Completed | University Magna Graecia | 50 | 2013-10-01 | 2018-05-29 |
| Randomized Study for the Assessment of Silibinin (Legalon® SIL) in the Treatment of naïve Genotype 4 Patients With Chronic Hepatitis C Legalon® SIL (Silibinin), Pegylated interferon alfa2b, Ribavirin - Hepatitis C, Chronic | Phase 2 / Phase 3 | Withdrawn | Rottapharm | 2013-08-01 | 2015-03-05 | |
| Effect of LEGALON SIL on Hepatitis C Virus Recurrence in Stable Liver Transplanted Patients Silibinin (Legalon-SIL), Saline - Hepatitis C Virus Recurrence | Phase 2 | Terminated | Rottapharm | 20 | 2011-08-01 | 2015-03-05 |
| Legalon SIL for the Treatment of HCV Recurrence in Liver Transplanted Patients Silibinin, Placebo - HCV Recurrence After Liver Transplantation | Phase 2 | Terminated | Rottapharm | 14 | 2010-09-01 | 2012-02-17 |
| Silybin - Vitamin E- Phospholipids Complex Reduces Liver Fibrosis in Patients With Chronic Hepatitis C Treated With Peg-IFN-a and RBV Silybin 94 mg + vitamin E 90 mg + phospholipids 194 mg complex, Placebo - Liver Fibrosis | Phase 3 | Completed | University of Catania | 64 | 2010-06-01 | 2013-09-05 |
| Silybin Supplementation During HCV Therapy With Pegylated Interferon-α2b Plus Ribavirin Reduces Depression and Increases Work Ability Silybin 94 mg + vitamin E 90 mg + phospholipids 194 mg, sugar pill - Work Ability, Depression | Phase 3 | Completed | University of Catania | 72 | 2010-02-01 | 2013-10-08 |
| Siliphos in Advanced Hepatocellular Carcinoma Silybin - Advanced Hepatocellular Carcinoma | Phase 1 | Completed | Abby Siegel | 3 | 2010-02-01 | 2013-11-25 |
| Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom Poisoning Silibinin - Amatoxin Poisoning, Amanita Poisoning | Phase 2 | Terminated | Mylan Specialty, LP | 148 | 2009-11-10 | 2022-04-07 |
| N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy N-acetylcysteine, silibin, high-dose silibin - Diabetic Nephropathies, Proteinuria | Phase 2 | Completed | The University of Texas Health Science Center at San Antonio | 114 | 2009-10-01 | 2016-06-27 |
| Intravenous Silibinin in Combination With Peg-interferon and Ribavirin in Nonresponders Silibinin - Hepatitis C | Phase 2 | Completed | Medical University of Vienna | 70 | 2007-10-01 | 2017-03-27 |
| The Effect of High-dose Silybin-phytosome in Men With Prostate Cancer Silibin-Phytosome - Prostate Cancer | Phase 2 | Completed | University of Colorado, Denver | 12 | 2006-08-01 | 2014-03-31 |
Brain Neoplasms (2) · Hepatitis C (2) · Hepatitis C, Chronic (2) · Inflammation (2) · Acne Vulgaris (1) · Breast Neoplasms (1) · COVID-19 (1) · Carcinoma, Non-Small-Cell Lung (1) · Depression (1) · Diabetic Nephropathies (1) · Essential Hypertension (1) · Fibrosis (1) · Glioblastoma (1) · Hypercholesterolemia (1) · Hypertension (1)
Rottapharm (3) · University of Catania (2) · A.O.U. Città della Salute e della Scienza (1) · Abby Siegel (1) · Assiut University (1) · F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica (1) · Guangzhou Medical University (1) · Istituto Clinico Humanitas (1) · Istituto Oncologico Veneto IRCCS (1) · Masonic Cancer Center, University of Minnesota (1) · Medical University of Graz (1) · Medical University of Vienna (1) · Mylan Specialty, LP (1) · The University of Texas Health Science Center at San Antonio (1) · Universidad Católica San Antonio de Murcia (1)
Italy (6) · United States (5) · Austria (2) · China (1) · Egypt (1) · Slovakia (1) · Spain (1)
Abby Siegel, MD, MS (1) · Alfredo Di Leo, MD (1) · Gamal Esmat, MD (1) · L. Michael Glode, M.D. (1) · Maria Perticone, MD (1) · Naomi Fujioka, MD (1) · Paolo Fanti, M.D. (1) · Samer El-Kamary, MD (1) · Wallis Marsh, MD (1) · Xavier Forns, Dr (1)
PMID 18771667, PMID 20127732, PMID 20709593, PMID 22155914, PMID 24673819, PMID 27842532, PMID 32517353, PMID 37916745, PMID 41406626
I01CX000264 (1), R21AT004490 (1)