10 completed. 10 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 10 |
| Phase 3 | 1 | Completed 1 |
Follow Appendicitis: new trials by email Literature Review of Appendicitis trials Research Report on Appendicitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA) Piperacillin/tazobactam, Normal saline, CefTRIAXone Injection - Appendicitis Perforated | Phase 2 | Completed | McMaster Children's Hospital | 16 | 2024-09-09 | 2026-07-07 |
| Antibiotic Instillation in Appendicitis Ceftriaxone, Intra-peritoneal Fluid Aspiration - Complicated Appendicitis, Acute Appendicitis | Phase 2 | Completed | Johns Hopkins All Children's Hospital | 190 | 2023-01-05 | 2025-03-13 |
| Laparoscopically Guided Rectus Sheath Block in Pediatric Appendicitis Rectus Sheath Block with 0.25% bupivicaine with 1:200 000 epinephrine, Local Anesthetic Infiltration with 0.25% bupivicaine with 1:200 000 epinephrine - Appendicitis Acute | Phase 2 | Completed | University of Alberta | 42 | 2021-05-28 | 2024-03-12 |
| The Role of Contrast Enhanced Ultrasound in Appendicitis Sulfur hexafluoride lipid-type A microspheres - Acute Appendicitis | Phase 2 | Completed | Children's Mercy Hospital Kansas City | 37 | 2019-01-04 | 2023-09-08 |
| Non-operative Treatment of Acute Non-perforated Appendicitis Meronem and flagyl, Appendectomy - Acute Appendicitis | Phase 2 / Phase 3 | Completed | King Edward Medical University | 180 | 2018-09-01 | 2021-02-18 |
| Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o., Standard antibiotics intravenously - Appendicitis Perforated | Phase 2 | Completed | Herlev Hospital | 13 | 2018-02-14 | 2018-10-16 |
| The Safety and Pharmacokinetics of Intraperitoneal Administration in Patients Undergoing Appendectomy for Uncomplicated Appendicitis A combination of fosfomycin, metronidazole and GM-CSF i.p. - Appendicitis | Phase 2 | Completed | Herlev Hospital | 14 | 2017-02-24 | 2019-05-29 |
| Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis Povidone-iodine irrigation, No irrigation - Acute, Perforated Appendicitis | Phase 2 | Completed | The University of Texas Health Science Center, Houston | 100 | 2016-04-01 | 2019-04-17 |
| Laparoscopic Management of Periappendicular Abscess Laparoscopic appendectomy, Conservative management with percutaneous drainage - Appendicitis, Abdominal Abscess | Phase 2 | Completed | Helsinki University Central Hospital | 60 | 2011-01-01 | 2014-09-23 |
| Study of Conservative Versus Surgical Treatment of Appendicitis cefotaxim and metronidazol - Appendicitis | Phase 2 | Completed | Göteborg University | 360 | 2006-05-01 | 2009-04-21 |
Cecal Diseases (10) · Digestive System Diseases (10) · Gastroenteritis (10) · Gastrointestinal Diseases (10) · Infections (10) · Intestinal Diseases (10) · Intraabdominal Infections (10) · Abscess (1) · Suppuration (1)
Metronidazole (4) · Ceftriaxone (2) · Appendectomy (1) · Benchmarking (1) · Cefotaxime (1) · Conservative Treatment (1) · Meropenem (1) · Piperacillin, Tazobactam Drug Combination (1) · Saline Solution (1) · regramostim (1)
Herlev Hospital (2) · Children's Mercy Hospital Kansas City (1) · Göteborg University (1) · Helsinki University Central Hospital (1) · Johns Hopkins All Children's Hospital (1) · King Edward Medical University (1) · McMaster Children's Hospital (1) · The University of Texas Health Science Center, Houston (1) · University of Alberta (1)
United States (3) · Canada (2) · Denmark (2) · Finland (1) · Pakistan (1) · Sweden (1)
Kent Lundholm (1) · KuoJen Tsao, MD (1) · Michael H Livingston, MD, MSc (1) · Nicole M. Chandler, MD (1) · Panu Mentula, M.D. Ph.D. (1) · Siv Fonnes, MD (1) · Tolulope Oyetunji, MD (1) · Troy Perry, MD (1)
PMID 11427329, PMID 19358184, PMID 21958060, PMID 25581711, PMID 27437029, PMID 31040341, PMID 31567357, PMID 32432123, PMID 41202087