32 unknown. 32 Phase 2, 10 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 32 | Unknown 32 |
| Phase 1 | 10 | Unknown 10 |
| Phase 3 | 2 | Unknown 2 |
Follow Anemia, Aplastic: new trials by email Literature Review of Anemia, Aplastic trials Research Report on Anemia, Aplastic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Standard Immunosuppressive Therapy Combined With Romiplostim N01 as First-line Treatment for Severe Aplastic Anemia standard IST combined with Romiplostim N01 - Aplastic Anemia, TPO Receptor Agonists | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 48 | 2024-10-24 | 2024-12-04 |
| NAC for Hematopoietic Recovery in SAA N Acetyl L Cysteine - Aplastic Anemia | Phase 2 | Unknown | Peking University People's Hospital | 30 | 2024-07-25 | 2024-07-24 |
| Sirolimus+Abatacept+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to Calcineurin Inhibitors Sirolimus, Abatacept, MMF - Acute Leukemia, Myelodysplastic Syndromes | Phase 1 / Phase 2 | Unknown | Peking University People's Hospital | 6 | 2024-03-01 | 2024-03-21 |
| Efficacy and Safety of Avatrombopag vs. Avatrombopag Combined With rhTPO in the Treatment of SAA Avatrombopag, Avatrombopag +rhTPO - Anemia, Aplastic | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 60 | 2024-02-01 | 2024-02-12 |
| Efficacy and Safety of CsA+AVA in the Treatment of NSAA in the Elderly Ciclosporin, Avatrombopag - Aplastic Anemia | Phase 2 | Unknown | Peking Union Medical College Hospital | 30 | 2023-08-17 | 2023-12-08 |
| Cyclophosphamide Added to Standard Immunosuppressive Therapy With Herombopag as Front-line Therapy in Patients With Severe Aplastic Anemia Cyclophosphamide added to standard immunosuppressive therapy with herombopag - Severe Aplastic Anemia | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 43 | 2023-07-10 | 2024-09-25 |
| Avatrombopag Combined With IST as First-line Treatment for SAA avatrombopag - Severe Aplastic Anemia | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 53 | 2022-11-10 | 2023-02-09 |
| GVHD Prophylaxis by Addition of CD20 Monoclonal Antibody to the Conditioning Regimen in SAA With Treatment of Allo-HSCT CD20 monoclonal antibody, ATG - Aplastic Anemia | Phase 2 | Unknown | The First Affiliated Hospital of Soochow University | 100 | 2021-12-30 | 2022-08-24 |
| Avatrombopag Usage in NSAA Avatrombopag 20 MG - Aplastic Anemia, Drug Effect | Phase 2 / Phase 3 | Unknown | Peking Union Medical College Hospital | 40 | 2021-02-01 | 2021-01-28 |
| Peripheral Blood Allogenic Stem Cell Transplantation Using Non-anti Thymocyte Globulin Regimens in Severe Aplastic Anemia Patients Non ATG Conditioning regimen, GVHD Prophylaxis, Allogenic Stem Cell Transplantation - Severe Aplastic Anemia | Phase 2 / Phase 3 | Unknown | Assiut University | 50 | 2019-01-01 | 2018-11-27 |
| A Novel TBI Free Conditioning Protocol for Haploidentical Transplant in Acquired Aplastic Anemia: Haploidentical HSCT using TBI free regimen, ''ATG'' with ''Post transplant cyclophosphamide'' - Aplastic Anemia Idiopathic | Phase 2 | Unknown | National Institute of Blood and Marrow Transplant (NIBMT), Pakistan | 30 | 2018-07-12 | 2020-08-11 |
| Efficacy and Safety of Thrombopoietin In Patients With Severe and Very Severe Aplastic Anemia rhTPO, placebo - Anemia, Aplastic | Phase 2 | Unknown | Tianjin Medical University General Hospital | 250 | 2016-08-01 | 2016-08-05 |
| Safety and Efficacy of Patient's Own AD-MSC and AD-HSC Transplantation in Patients With Severe Aplastic Anemia Rabbit antithymoglobulin (ATG), Adipose derived mesenchymal stem cells ( AD-MSCs), AD-MSC transdifferentiated HSCs (AD-HSCs) - Severe Aplastic Anemia | Phase 1 / Phase 2 | Unknown | Navy General Hospital, Beijing | 90 | 2015-01-01 | 2015-04-03 |
| L-leucine in Diamond Blackfan Anemia Patients L-leucine - Diamond Blackfan Anemia | Phase 2 | Unknown | Federal Scientific Clinical Centre of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogache | 30 | 2014-09-01 | 2015-03-11 |
| Effectiveness and Safety of MMSCs for Enhancing Hematopoietic Recovery and Prophylaxis of Neutropenic Enterocolitis Peripheral blood stem cell mobilisation and collection, High-dose chemotherapy, Bone marrow derived allogeneic MMSCs infusion - Neutropenic Enterocolitis, Myeloablative Chemotherapy Induced Bone Marrow Aplasia | Phase 1 / Phase 2 | Unknown | Burnasyan Federal Medical Biophysical Center | 16 | 2014-05-01 | 2015-06-10 |
| Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single Vaccination allogeneic donor derived B-lymphocytes - Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Unknown | University of Erlangen-Nürnberg Medical School | 15 | 2013-11-01 | 2014-03-26 |
| CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant CliniMACS CD34+ Reagent System, Thiotepa, Cyclophosphamide - Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML) | Phase 1 / Phase 2 | Unknown | Diane George | 14 | 2013-06-03 | 2024-06-04 |
| Mesenchymal Stem Cells Co-transplantation in Alternative Donor Transplantation of Severe Aplastic Anemia. mesenchymal stem cells - Severe Aplastic Anemia | Phase 2 | Unknown | Guangzhou General Hospital of Guangzhou Military Command | 100 | 2013-02-01 | 2014-09-25 |
| Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013) Levamisole+cyclosporin A+Glucocorticoids, cyclosporin A+Glucocorticoids, Glucocorticoids - Paroxysmal Nocturnal Hemoglobinuria, Hemoglobinuria | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 50 | 2013-01-01 | 2013-01-03 |
| Haploidentical Stem Cell Transplantation for Children With Acquired Severe Aplastic Anemia Fludarabine, Cyclophosphamide, anti-thymocyte globulin - Acquired Aplastic Anemia | Phase 2 | Unknown | Asan Medical Center | 10 | 2012-09-01 | 2013-01-03 |
Showing 20 of 32. Sign in to see all of them.
Myelodysplastic Syndromes (4) · Bone Marrow Failure Disorders (3) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (3) · Anemia (2) · Anemia, Diamond-Blackfan (2) · Anemia, Hemolytic (2) · Hematologic Diseases (2) · Hemoglobinuria (2) · Hemoglobinuria, Paroxysmal (2) · Hodgkin Disease (2) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (2) · Leukemia, Myeloid, Acute (2) · Leukemia, Myelomonocytic, Juvenile (2) · Lymphoma (2)
Hemic and Lymphatic Diseases (32) · Bone Marrow Diseases (31) · Anemia (30) · Hematologic Diseases (30) · Bone Marrow Failure Disorders (29) · Immune System Diseases (6) · Immunoproliferative Disorders (5) · Lymphatic Diseases (5) · Lymphoproliferative Disorders (5) · Neoplasms (5) · Neoplasms by Histologic Type (5) · Pathological Conditions, Signs and Symptoms (5) · Anemia, Hypoplastic, Congenital (3) · Cardiovascular Diseases (3) · Chronic Disease (3)
Cyclosporine (6) · Cyclophosphamide (5) · fludarabine (5) · avatrombopag (4) · Alemtuzumab (2) · Antilymphocyte Serum (2) · Busulfan (2) · Glucocorticoids (2) · Levamisole (2) · Melphalan (2) · Methylprednisolone (2) · Sirolimus (2) · Whole-Body Irradiation (2) · fludarabine phosphate (2) · thymoglobulin (2)
Institute of Hematology & Blood Diseases Hospital, China (6) · The Korean Society of Pediatric Hematology Oncology (3) · Guangzhou General Hospital of Guangzhou Military Command (2) · Peking Union Medical College Hospital (2) · Peking University People's Hospital (2) · Asan Medical Center (1) · Assiut University (1) · Burnasyan Federal Medical Biophysical Center (1) · Diane George (1) · Federal Scientific Clinical Centre of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogache (1) · Federico II University (1) · Milton S. Hershey Medical Center (1) · National Institute of Blood and Marrow Transplant (NIBMT), Pakistan (1) · Navy General Hospital, Beijing (1) · Office of Rare Diseases (ORD) (1)
China (14) · South Korea (5) · United States (3) · Germany (2) · Russia (2) · Austria (1) · Italy (1) · Pakistan (1)
Hyo Seop Ahn, M.D, Ph.D (2) · Yang Xiao, MD (2) · Bruno Rotoli, MD (1) · Demao Yang, PhD (1) · Diane George, MD (1) · Ho Joon Im, MD, PhD (1) · Hyoung Jin Kang, MD., PhD (1) · Ilya I Eremin, MD, PhD (1) · Julia Winkler, MD (1) · Jun Shi, PhD (1) · Kenneth G. Lucas, MD (1) · Liwei Fang, MD (1)
PMID 20685256, PMID 22055111, PMID 23731760, PMID 25310303, PMID 37318085, PMID 38467031
U54RR019397 (1)