17 completed, 5 unknown, 4 not yet recruiting, 3 terminated. 31 Phase 3, 14 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 31 | Completed 17, Unknown 5, Not yet recruiting 4, Terminated 3, Suspended 1, Withdrawn 1 |
| Phase 2 | 14 | Completed 10, Unknown 2, Not yet recruiting 1, Withdrawn 1 |
Follow Anemia, Aplastic: new trials by email Literature Review of Anemia, Aplastic trials Research Report on Anemia, Aplastic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methadone as an Alternative Treatment for Children Underdoing HSCT PCA plus methadone (Experimental), PCA Alone (SOC) - Leukemia, Aplastic Anemia | Phase 3 | Suspended | University of Texas Southwestern Medical Center | 60 | 2028-01-01 | 2025-10-23 |
| Prophylactic NAC to Improve Platelet Engraftment After Haploidentical Transplantation in Severe Aplastic Anemia Patients N-acetylcysteine - Aplastic Anemia | Phase 3 | Not yet recruiting | Peking University People's Hospital | 142 | 2026-09-30 | 2026-09-16 |
| A Study of Avatrombopag in Adults With Aplastic Anemia Who Did Not Respond to, Cannot Receive, or Had Return of Disease After Standard Treatment Avatrombopag 20 mg Oral Tablet - Aplastic Anemia | Phase 2 / Phase 3 | Not yet recruiting | Swedish Orphan Biovitrum | 26 | 2026-07-31 | 2026-08-26 |
| Study on the Short-term Efficacy and Safety of Recombinant Human Thrombopoietin Combined With Immunosuppressant Sequential Eltrombopag Ethanolamine Dry Suspension in the Treatment of SAA/TD-NSAA EPAG-pfos - Aplastic Anemias | Phase 3 | Not yet recruiting | Peking Union Medical College Hospital | 70 | 2025-06-23 | 2025-06-03 |
| Outcomes in Bone Marrow Aplasia. Eltrombopag - Aplastic Anemia Idiopathic | Phase 3 | Not yet recruiting | Assiut University | 3 | 2024-07-01 | 2024-07-10 |
| A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202) cyclosporine, Matched Unrelated Donor Hematopoetic Stem Cell Transplant, horse anti-thymocyte globulin (ATG) - Severe Aplastic Anemia | Phase 3 | Terminated | Boston Children's Hospital | 53 | 2023-01-25 | 2026-10-19 |
| Safety and Efficacy of Metformin for Treatment of Cytopenia in Children and Adolescents With Fanconi Anemia Metformin - Fanconi Anemia | Phase 3 | Unknown | Ain Shams University | 30 | 2022-10-05 | 2024-07-25 |
| Efficacy and Safety of Hetrombopag in Non-severe Aplastic Anemia Hetrombopag - Aplastic Anemia, Drug Effect | Phase 2 / Phase 3 | Withdrawn | Peking Union Medical College Hospital | 2021-10-01 | 2026-06-08 | |
| Avatrombopag Usage in NSAA Avatrombopag 20 MG - Aplastic Anemia, Drug Effect | Phase 2 / Phase 3 | Unknown | Peking Union Medical College Hospital | 40 | 2021-02-01 | 2021-01-28 |
| A Study to Assess Efficacy and Safety of PF-06462700 in Japanese Participants With Aplastic Anemia PF-06462700 - Aplastic Anemia | Phase 3 | Completed | Pfizer | 3 | 2020-07-25 | 2022-04-27 |
| Study of AMG531 (Romiplostim) in Patients With Aplastic Anemia Romiplostim - Aplastic Anemia | Phase 2 / Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 24 | 2019-12-03 | 2022-05-26 |
| Study of AMG531(Romiplostim) in Patients With Aplastic Anemia Romiplostim - Aplastic Anemia | Phase 2 / Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 17 | 2019-04-25 | 2022-05-26 |
| Hetrombopag or Placebo in Treatment-Naive Severe Aplastic Anemia Hetrombopag Olamine+Standard Therapy, Placebo+Standard Therapy - Severe Aplastic Anemia | Phase 3 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 240 | 2019-03-05 | 2024-11-07 |
| Peripheral Blood Allogenic Stem Cell Transplantation Using Non-anti Thymocyte Globulin Regimens in Severe Aplastic Anemia Patients Non ATG Conditioning regimen, GVHD Prophylaxis, Allogenic Stem Cell Transplantation - Severe Aplastic Anemia | Phase 2 / Phase 3 | Unknown | Assiut University | 50 | 2019-01-01 | 2018-11-27 |
| Eltrombopag+hATG+CsA vs. hATG+CsA in Children With Severe AA Eltrombopag, IST (ATG + CsA) - Acquired Aplastic Anemia | Phase 3 | Unknown | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 100 | 2016-12-10 | 2021-03-15 |
| Study of Romiplostim(AMG531) in Subjects With Aplastic Anemia Romiplostim - Aplastic Anemia | Phase 2 / Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 46 | 2016-05-01 | 2024-07-16 |
| hATG+CsA vs hATG+CsA+Eltrombopag for SAA hATG, CsA, Eltrombopag - Severe Aplastic Anemia | Phase 3 | Completed | European Society for Blood and Marrow Transplantation | 202 | 2015-07-01 | 2026-04-24 |
| Efficacy and Safety of Eltrombopag + CSA in Patients With Moderate Aplastic Anemia (EMAA) Eltrombopag, Placebo (for Eltrombopag) - Anemia, Aplastic | Phase 2 / Phase 3 | Completed | B. Höchsmann | 93 | 2015-01-27 | 2025-06-10 |
| Trial of Two Central Venous Catheter (CVC) Flushing Schemes in Pediatric Hematology and Oncology Patients Heparin, Normal saline - Childhood Cancer, Aplastic Anemia | Phase 3 | Terminated | Alberta Children's Hospital | 2 | 2011-04-01 | 2012-05-30 |
| Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia Cy-ATG, Flu-ATG - Aplastic Anemia | Phase 3 | Unknown | Cooperative Study Group A for Hematology | 98 | 2010-03-01 | 2012-09-07 |
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Anemia, Diamond-Blackfan (4) · Bone Marrow Failure Disorders (4) · Fanconi Anemia (3) · Neoplasms (3) · Thalassemia (3) · Anemia (2) · Anemia, Sickle Cell (2) · Hematologic Diseases (2) · Leukemia (2) · Myelodysplastic Syndromes (2) · Primary Myelofibrosis (2) · Shwachman-Diamond Syndrome (2) · Anemia, Refractory (1) · Anemia, Refractory, with Excess of Blasts (1)
Bone Marrow Diseases (31) · Hemic and Lymphatic Diseases (31) · Anemia (29) · Hematologic Diseases (29) · Bone Marrow Failure Disorders (27) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (9) · Congenital Bone Marrow Failure Syndromes (8) · Genetic Diseases, Inborn (8) · Anemia, Hypoplastic, Congenital (7) · Nutritional and Metabolic Diseases (6) · Metabolic Diseases (5) · Pathological Conditions, Signs and Symptoms (4) · Red-Cell Aplasia, Pure (4) · Anemia, Hemolytic (3)
Antilymphocyte Serum (9) · Cyclophosphamide (8) · fludarabine (6) · fludarabine phosphate (6) · Whole-Body Irradiation (5) · Bone Marrow Transplantation (4) · Busulfan (4) · eltrombopag (4) · thymoglobulin (4) · Alemtuzumab (3) · Stem Cell Transplantation (3) · romiplostim (3) · Deferasirox (2) · Granulocyte Colony-Stimulating Factor (2) · Radiotherapy (2)
Masonic Cancer Center, University of Minnesota (4) · Kyowa Kirin Co., Ltd. (3) · Peking Union Medical College Hospital (3) · Assiut University (2) · European Society for Blood and Marrow Transplantation (2) · Novartis Pharmaceuticals (2) · Roswell Park Cancer Institute (2) · Ain Shams University (1) · Alberta Children's Hospital (1) · B. Höchsmann (1) · Boston Children's Hospital (1) · Columbia University (1) · Cooperative Study Group A for Hematology (1) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology (1) · Jiangsu HengRui Medicine Co., Ltd. (1)
United States (10) · China (4) · Germany (4) · Italy (4) · Japan (4) · Netherlands (4) · United Kingdom (4) · Canada (3) · France (3) · Greece (3) · South Korea (3) · Spain (3) · Switzerland (3) · Belgium (2) · Egypt (2)
Alexei Maschan (1) · Angela Smith, MD (1) · Antonio Risitano, MD, PhD (1) · Bing Han, Master (1) · Bronwen Shaw, MD (1) · David Williams, MD (1) · Galina Novichkova (1) · Hawk Kim, professor (1) · Jakub Tolar, M.D., Ph.D. (1) · James Garvin, MD, PhD (1) · Margaret L MacMillan, M.D. (1) · Martin A Campbell, MBBS FRACP (1)
PMID 19951979, PMID 19996412, PMID 20383216, PMID 20566896, PMID 21071497, PMID 21233311, PMID 22526363, PMID 23585526, PMID 25691036, PMID 31582549, PMID 34986284, PMID 35446936, PMID 36441357, PMID 37318085, PMID 38088156, PMID 40593138, PMID 42047558, PMID 42611779
1UG3HL157564-01A1 (1), 2004 (1), 2014 (1), U24HL157560 (1)