73 completed, 19 terminated, 12 recruiting, 8 unknown. 56 Phase 2, 35 Phase 1, 14 Not applicable, 12 Phase 3, 1 Phase 4.
Follow Leukemia, Myelomonocytic, Juvenile: new trials by email Literature Review of Leukemia, Myelomonocytic, Juvenile trials Research Report on Leukemia, Myelomonocytic, Juvenile
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Therapeutic RSK1 Targeting in Myeloid Malignancies PMD-026 - Myeloid Malignancy | Phase 1 | Recruiting | Washington University School of Medicine | 30 | 2026-05-20 | 2026-10-21 |
| Clonal Hematopoiesis of Immunological Significance observational cohort study - Immune System Diseases, Autoimmune Diseases | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 5000 | 2026-04-01 | 2026-03-23 | |
| A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Myelodysplastic Syndrome | Phase 1 | Recruiting | Children's Oncology Group | 36 | 2025-02-04 | 2026-08-25 |
| A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia Trametinib, Azacitidine, Fludarabine - Leukemia, Juvenile Myelomonocytic, JMML | Phase 1 / Phase 2 | Recruiting | Therapeutic Advances in Childhood Leukemia Consortium | 58 | 2024-10-11 | 2026-09-04 |
| Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases Miltenyi CliniMACS Prodigy ® system - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 2 | Recruiting | University of Florida | 20 | 2024-05-03 | 2026-06-04 |
| MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies Fludarabine, Busulfan, Melphalan - Hematologic Malignancy, Acute Leukemia | Phase 2 | Recruiting | Masonic Cancer Center, University of Minnesota | 70 | 2023-05-11 | 2026-04-06 |
| Study of CPX-351 (VYXEOS) in Individuals < 22 Years With Secondary Myeloid Neoplasms CPX-351, MHA, Allogeneic Hematopoietic Stem Cell Transplantation - Myeloid Neoplasm | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 25 | 2023-01-17 | 2026-10-15 |
| Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Calcineurin Inhibitor at Patients With Hemoblastosis GVHD prevention: post-transplantation cyclophosphamide, abatacept, vedolizumab, calcineurin inhibitor - Acute Lymphoblastic Leukemia, Myeloblastic Leukemia | Phase 3 | Active not recruiting | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 56 | 2022-08-23 | 2023-09-28 |
| The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study Biospecimen Collection - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 / Phase 2 | Recruiting | PedAL BCU, LLC | 960 | 2022-04-18 | 2026-08-25 |
| A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation CIML NK, Fludarabine, Cyclophosphamide - Acute Myeloid Leukemia, Myelodysplastic Syndromes | Phase 1 | Recruiting | Dana-Farber Cancer Institute | 50 | 2019-08-31 | 2026-06-17 |
| Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell Transplantation Vorinostat, Azacitidine Injection - Acute Myeloid Leukemia, Myelodysplastic Syndromes | Phase 1 | Active not recruiting | Johns Hopkins All Children's Hospital | 15 | 2019-05-01 | 2026-07-15 |
| CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Depleted Peripheral Stem Cell Addback - Acute Leukemia, Acute Myeloid Leukemia | Not applicable | Recruiting | Children's Hospital of Philadelphia | 50 | 2019-03-01 | 2026-07-08 |
| TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies Cyclophosphamide, Fludarabine, Thiotepa - Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML) | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 69 | 2019-01-31 | 2026-09-15 |
| Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia Bone Marrow Aspiration and Biopsy, Trametinib - Juvenile Myelomonocytic Leukemia, Neurofibromatosis Type 1 | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 10 | 2018-09-09 | 2026-07-20 |
| Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders HSCT with TBI Regimen, HSCT with Non-TBI Regimen - Acute Leukemia, Acute Myeloid Leukemia | Phase 2 | Recruiting | Masonic Cancer Center, University of Minnesota | 300 | 2018-03-30 | 2026-06-25 |
| HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant CD8+ and CD4+ Donor Memory T-cells-expressing HA1-Specific TCR, Bone Marrow Aspiration, Biospecimen Collection - Juvenile Myelomonocytic Leukemia, Recurrent Acute Biphenotypic Leukemia | Phase 1 | Recruiting | Fred Hutchinson Cancer Center | 24 | 2018-02-23 | 2026-05-18 |
| Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS) Pacritinib, Decitabine - Chronic Myelomonocytic Leukemia, Juvenile Myelomonocytic Leukemia | Phase 1 | Withdrawn | Washington University School of Medicine | 2017-06-01 | 2017-05-08 | |
| Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation Anti-thymocyte globulin (rabbit), Blinatumomab, Cyclophosphamide - Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML) | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 170 | 2016-07-14 | 2025-08-12 |
| Yttrium-90 Anti CD66 Monoclonal Antibody in Childhood Relapsed/Refractory Leukaemia Yttrium-90 labelled monoclonal antibody against CD66 - Acute Myeloblastic Leukemia, Acute Lymphoblastic Leukemia | Phase 1 | Completed | Great Ormond Street Hospital for Children NHS Foundation Trust | 9 | 2016-05-01 | 2021-06-25 |
| Study With Azacitidine in Pediatric Subjects With Newly Diagnosed Advanced Myelodysplastic Syndrome (MDS) and Juvenile Myelomonocytic Leukemia (JMML) Azacitidine - Myelodysplastic Syndrome, Leukemia, Myelomonocytic, Juvenile | Phase 2 | Completed | Celgene | 28 | 2015-09-15 | 2019-07-11 |
Showing 20 of 125. Sign in to see all of them.
Precursor Cell Lymphoblastic Leukemia-Lymphoma (95) · Leukemia, Myeloid, Acute (81) · Myelodysplastic Syndromes (69) · Leukemia, Myelomonocytic, Chronic (67) · Myeloproliferative Disorders (59) · Burkitt Lymphoma (58) · Leukemia (58) · Leukemia, Lymphocytic, Chronic, B-Cell (56) · Leukemia, Myeloid, Chronic-Phase (53) · Lymphoma, Non-Hodgkin (53) · Recurrence (53) · Dendritic Cell Sarcoma, Interdigitating (52) · Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative (52) · Leukemia, Myeloid, Accelerated Phase (50)
Hemic and Lymphatic Diseases (125) · Leukemia, Myeloid (125) · Neoplasms by Histologic Type (125) · Bone Marrow Diseases (123) · Hematologic Diseases (122) · Neoplasms (110) · Immune System Diseases (103) · Pathological Conditions, Signs and Symptoms (102) · Immunoproliferative Disorders (101) · Lymphatic Diseases (101) · Pathologic Processes (100) · Disease Attributes (98) · Leukemia, Lymphoid (97) · Lymphoproliferative Disorders (96) · Chronic Disease (93)
Cyclophosphamide (32) · fludarabine phosphate (30) · Mycophenolic Acid (24) · Busulfan (21) · Antilymphocyte Serum (20) · Tacrolimus (19) · Methotrexate (18) · Peripheral Blood Stem Cell Transplantation (18) · Filgrastim (17) · Melphalan (17) · Cyclosporine (15) · Whole-Body Irradiation (15) · Cytarabine (11) · Methylprednisolone (11) · fludarabine (11)
Fred Hutchinson Cancer Center (19) · Children's Oncology Group (11) · St. Jude Children's Research Hospital (11) · Masonic Cancer Center, University of Minnesota (7) · National Cancer Institute (NCI) (5) · University of California, San Francisco (5) · Case Comprehensive Cancer Center (4) · Memorial Sloan Kettering Cancer Center (4) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (4) · Celgene (2) · City of Hope Medical Center (2) · Columbia University (2) · M.D. Anderson Cancer Center (2) · Milton S. Hershey Medical Center (2) · OHSU Knight Cancer Institute (2)
United States (108) · Canada (14) · Australia (8) · Germany (5) · Italy (5) · New Zealand (4) · Puerto Rico (4) · Switzerland (3) · United Kingdom (3) · France (2) · Netherlands (2) · Austria (1) · Belgium (1) · Czechia (1) · Denmark (1)
Brandon Triplett, MD (4) · Gregory Hale, M.D. (3) · Kenneth G. Lucas, MD (3) · Brenda Sandmaier (2) · Colleen Delaney, MD, MSC (2) · David Maloney (2) · Elisabeth Paietta, PhD (2) · George Chen (2) · Maryam Fouladi (2) · Paul Martin (2) · Adam J. Esbenshade, MD (1) · Alan S. Gamis, MD, MPH (1) · Alexandra M Stevens (1) · Amy W Zhou, M.D. (1) · Ann E. Woolfrey, MD (1)
PMID 32499241, PMID 20802024, PMID 40554414, PMID 17562873, PMID 18698002, PMID 18989154, PMID 18997171, PMID 19270260, PMID 19706886, PMID 20860038, PMID 21849481, PMID 22392565, PMID 22504933, PMID 24162791, PMID 24786393, PMID 25425683, PMID 25644958, PMID 26296092, PMID 26700120, PMID 26700123, PMID 28817727, PMID 29217778, PMID 33728588, PMID 34297046, PMID 34893945, PMID 35349491, PMID 37257193, PMID 37584291, PMID 37944074, PMID 38683966, PMID 38867349
P30CA015704 (5), U10CA098543 (5), P01CA018029 (3), P30CA068485 (3), U10CA180886 (3), P30CA006973 (2), P30CA008748 (2), P30CA033572 (2), P30CA043703 (2), U01CA097452 (2), U10CA032102 (2), P01CA015396 (1), P01CA023766 (1), P01CA078902 (1), P30CA015083 (1)