5 completed, 5 terminated, 2 recruiting, 2 withdrawn. 9 Phase 1, 7 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 3, Recruiting 2, Terminated 2, Active not recruiting 1, Withdrawn 1 |
| Phase 2 | 7 | Terminated 4, Completed 1, Recruiting 1, Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow Anaplastic Ependymoma: new trials by email Literature Review of Anaplastic Ependymoma trials Research Report on Anaplastic Ependymoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors LUTATHERA® (Lutetium Lu 177 dotatate) - High Grade Glioma, Meningioma | Phase 1 / Phase 2 | Recruiting | Nationwide Children's Hospital | 65 | 2022-11-21 | 2026-07-20 |
| A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma SurVaxM for patients with relapsed or progressive MB, HGG or ependymoma ages ≥10 and ≤21 years, SurVaxM for patients with relapsed or progressive MB, HGG or ependymoma ages ≥1 and <10 years, SurVaxM for patients with non-relapsed DIPG post radiation-therapy ages ≥1 and ≤21 years - Medulloblastoma, Glioblastoma Multiforme | Phase 1 | Active not recruiting | Children's Oncology Group | 35 | 2022-07-01 | 2026-06-02 |
| Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer Etoposide, Fludarabine Phosphate, Hematopoietic Cell Transplantation - Anaplastic Ependymoma, Atypical Teratoid/Rhabdoid Tumor | Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2021-01-14 | 2024-10-26 | |
| Marizomib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial, and Spinal Cord Ependymoma Marizomib - Anaplastic Ependymoma, Ependymoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 4 | 2020-01-22 | 2022-07-27 |
| LET Optimized IMPT in Treating Pediatric Patients With Ependymoma Linear Energy Transfer-Optimized Intensity Modulated Proton Therapy, Quality-of-Life Assessment, Questionnaire Administration - Anaplastic Ependymoma, Ependymoma | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 48 | 2019-04-01 | 2026-11-10 |
| SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Gemcitabine, ribociclib, sonidegib - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | St. Jude Children's Research Hospital | 68 | 2018-03-05 | 2024-05-31 |
| Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma Laboratory Biomarker Analysis, Lapatinib, Lapatinib Ditosylate - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | National Cancer Institute (NCI) | 29 | 2016-11-07 | 2024-11-06 |
| Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine Heat Shock Protein Peptide Complex-96 (HSPPC-96), Tumor Resection, Radiation - Glioblastoma Multiforme, Astrocytoma, Grade III | Phase 1 | Terminated | Ann & Robert H Lurie Children's Hospital of Chicago | 10 | 2016-07-01 | 2025-02-18 |
| Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors imetelstat sodium - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 2 | Terminated | Pediatric Brain Tumor Consortium | 43 | 2013-03-01 | 2018-07-20 |
| Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant Astrocytomas AXL1717 - Glioblastoma, Gliosarcoma | Phase 1 / Phase 2 | Terminated | Rush University Medical Center | 10 | 2012-12-01 | 2023-05-22 |
| Carboplatin and Bevacizumab for Recurrent Ependymoma Carboplatin, Bevacizumab - Ependymoma, Anaplastic Ependymoma | Phase 2 | Completed | National Cancer Institute (NCI) | 35 | 2011-04-27 | 2025-08-05 |
| Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 therapeutic allogeneic lymphocytes, aldesleukin, laboratory biomarker analysis - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | City of Hope Medical Center | 6 | 2011-03-22 | 2026-10-19 |
| Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma 3-Dimensional Conformal Radiation Therapy, Carboplatin, Cisplatin - Anaplastic Ependymoma, Brain Ependymoma | Phase 3 | Completed | Children's Oncology Group | 479 | 2010-05-07 | 2026-04-30 |
| Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma ritonavir, lopinavir - Brain Tumor, Anaplastic Astrocytoma | Phase 2 | Terminated | Case Comprehensive Cancer Center | 19 | 2009-01-01 | 2013-06-10 |
| Photodynamic Therapy in the Treatment of Malignant Intracranial Tumors Photodynamic therapy using Photosan and LumaCare™ Lamp Model LC-122M - Malignant Intracranial Tumors, Glioblastoma Multiforme | Phase 2 | Withdrawn | National Taiwan University Hospital | 5 | 2010-01-12 |
Ependymoma (15) · Astrocytoma (9) · Glioblastoma (9) · Oligodendroglioma (8) · Glioma (7) · Brain Neoplasms (6) · Gliosarcoma (5) · Medulloblastoma (4) · Meningioma (3) · Neuroectodermal Tumors, Primitive (3) · Central Nervous System Neoplasms (2) · Choroid Plexus Carcinoma (2) · Diffuse Intrinsic Pontine Glioma (2) · Neoplasms (2) · Neoplasms, Germ Cell and Embryonal (2)
Neoplasms by Histologic Type (15) · Neoplasms, Glandular and Epithelial (15) · Neoplasms, Nerve Tissue (15) · Neuroectodermal Tumors (15) · Neoplasms, Neuroepithelial (14) · Neoplasms (13) · Neoplasms, Germ Cell and Embryonal (13) · Brain Diseases (9) · Central Nervous System Diseases (9) · Neoplasms by Site (9) · Nervous System Diseases (9) · Nervous System Neoplasms (9) · Glioma (8) · Central Nervous System Neoplasms (7) · Brain Neoplasms (3)
Carboplatin (2) · Etoposide (2) · Filgrastim (2) · Granulocyte Colony-Stimulating Factor (2) · 1,2-diaminocyclohexaneplatinum II citrate (1) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Antilymphocyte Serum (1) · Bevacizumab (1) · Cisplatin (1) · Cyclophosphamide (1) · GRN163L peptide (1) · Gemcitabine (1) · Hematopoietic Stem Cell Transplantation (1) · Interleukin-2 (1) · Interleukins (1)
National Cancer Institute (NCI) (3) · Children's Oncology Group (2) · M.D. Anderson Cancer Center (2) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Case Comprehensive Cancer Center (1) · City of Hope Medical Center (1) · National Taiwan University Hospital (1) · Nationwide Children's Hospital (1) · Pediatric Brain Tumor Consortium (1) · Rush University Medical Center (1) · St. Jude Children's Research Hospital (1)
United States (13) · Canada (2) · Australia (1) · New Zealand (1) · Taiwan (1)
Amy A Smith (1) · Behnam Badie (1) · Clare Twist, MD (1) · David Peereboom, MD (1) · David R Grosshans (1) · Giles W. Robinson, MD (1) · Jui-Chang Tsai, M.D. Ph.D. (1) · Kevin Camphausen, M.D. (1) · Kris M Mahadeo, MD (1) · Margot Lazow, MD (1) · Mark R Gilbert, M.D. (1) · Maryam Fouladi (1) · Robert Aiken, MD (1) · Stewart Goldman, MD (1) · Timothy F Cloughesy (1)
P30CA016672 (1), U01CA081457 (1), U01CA137443 (1), U10CA098543 (1), U10CA180886 (1), U19CA021239 (1), UM1CA081457 (1), UM1CA137443 (1)