323 completed, 82 recruiting, 71 unknown, 60 terminated. 318 Phase 1, 137 Not applicable, 126 Phase 2, 27 Phase 3, 4 Early Phase 1.
Follow Advanced Cancer: new trials by email Literature Review of Advanced Cancer trials Research Report on Advanced Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination of Osemitamab (TST001), Pembrolizumab and Chemotherapy as First-line Therapy in Advanced or Metastatic GC/GEJ Adenocarcinoma Pembrolizumab and either Capcecitabine + Oxaliplatin or Oxaliplatin+Leucovorin + 5-fluorouracil - Gastric Cancer, Gastroesophageal-junction Cancer | Phase 3 | Not yet recruiting | Transcenta Therapeutics (Hangzhou) Co., Ltd. | 820 | 2027-06-30 | 2026-09-29 |
| Healing Gardens: Leveraging Serious Games to Deliver Accessible Pain-CBT and Pharmacologic Support for Patients With Advanced Cancer Managing Pain Healing Gardens content development/refinement activities, Healing Gardens serious game - Advanced Cancer, Cancer Pain | Not applicable | Not yet recruiting | Dana-Farber Cancer Institute | 46 | 2027-02-13 | 2026-09-17 |
| The FamilyStrong Pilot Randomized Trial FamilyStrong - Family Caregivers, Distress in Caregivers of Cancer Patients | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 120 | 2027-01-01 | 2026-08-13 |
| Symptom Trajectory Approaches to Research Health surveys - Advanced Cancer, Metastatic Disease | Not yet recruiting | University of Wisconsin, Madison | 228 | 2026-12-01 | 2026-09-04 | |
| Cancer Pain 101: A Digital, Asynchronous Intervention of Pain Management in Advanced Cancer Cancer Pain 101 - Cancer, Pain | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 45 | 2026-11-01 | 2026-10-20 |
| MB-PAT for Demoralization in Advanced Cancer ('PAT-MIND') Trial PEX010 25 mg psilocybin, PEX010 5 mg psilocybin, Standard Psilocybin-Assisted Therapy - Advanced Cancer, Demoralization | Phase 2 | Not yet recruiting | University of Calgary | 60 | 2026-10-30 | 2026-09-02 |
| A Feasibility Study of a Digitally-enabled Psychological Intervention for Demoralization in Advanced Cancer Patients A digitally-enabled positive psychological intervention for demoralization in advanced cancer patients - Advanced Cancer, Demoralization | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 30 | 2026-10-28 | 2026-10-13 |
| Primary Palliative Care - a Feasibility Cluster Trial Primary Palliative Care Complex Intervention (PrimPal) - Palliative Care, Primary Palliative Care | Not applicable | Not yet recruiting | University of Coimbra | 30 | 2026-10-01 | 2026-08-03 |
| Integrated Smartphone Technology to Alleviate Malignant Pain (I-STAMP) Testing I-STAMP - Advanced Cancer, Pain | Not applicable | Recruiting | Dana-Farber Cancer Institute | 73 | 2026-09-18 | 2026-10-13 |
| Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Randomized Controlled Trial Psilocybin (high dose), Psilocybin (low dose), PEARL Therapy - Advanced Cancer, Stage IV Solid Tumor Cancer | Phase 2 | Not yet recruiting | University Health Network, Toronto | 46 | 2026-09-14 | 2026-10-15 |
| An Open-Label Study to Evaluate PF-07994525 in Participants With Advanced Cancers PF-07994525, Midazolam - Advanced Malignancies, Advanced Cancer | Phase 1 | Recruiting | Pfizer | 120 | 2026-07-01 | 2026-10-13 |
| Contrast-enhanced CBCT With C-arm HyperSight Technology Intravenous contrast-enhanced cone beam computed tomography - Advanced Cancer | Not applicable | Recruiting | University Health Network, Toronto | 20 | 2026-06-24 | 2026-06-26 |
| Virtual Group Resilient Living Program For Patients Living With Advanced Cancer Virtual Group Resilient Living Program (RLP), Survey Completion - Advanced Cancer | Not applicable | Recruiting | Mayo Clinic | 42 | 2026-06-19 | 2026-07-02 |
| Resilience-Building for Advance Care Planning ROCKS, Usual Care - Advanced Cancer, End of Life | Not applicable | Recruiting | University of Illinois at Chicago | 152 | 2026-06-09 | 2026-10-08 |
| Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy in Patients With Cancer-Related Celiac Pain Treatment plan - Advanced Cancer, Pancreatic Cancer | Not applicable | Recruiting | University Health Network, Toronto | 5 | 2026-06-04 | 2026-07-30 |
| Electroacupuncture for Preventing Chemotherapy-Induced Peripheral Neuropathy in Patients With Advanced Cancer True electroacupuncture, True thumbtack needle, Sham electroacupuncture - Electroacupuncture, Chemotherapy | Not applicable | Not yet recruiting | Affiliated Hospital of Qinghai University | 264 | 2026-05-25 | 2026-06-12 |
| Phase 1/2 Study of UI-102 in Selected Advanced Cancers UI-102 - Advanced Cancer | Phase 1 / Phase 2 | Recruiting | United Immunity, co., Ltd. | 140 | 2026-05-20 | 2026-06-03 |
| Safety Evaluation of Bioactive Glass Based Bone Cement Combined With Ultrasound in Implantation for Metastatic Bone Tumors Bioactive Glass Bone Cement + Ultrasound - Advanced Cancer, Pain | Not applicable | Not yet recruiting | Liao Yun | 8 | 2026-05-01 | 2026-04-20 |
| A Pilot Randomized Controlled Trial of a Social Network Intervention SONATA - Advanced Cancer, Older Adults (65 Years and Older) | Not applicable | Recruiting | University of Rochester | 70 | 2026-04-10 | 2026-07-07 |
| Methods of Identifying Effective Off-Guideline Treatments for Advanced Cancer Patients Advanced Cancer | Recruiting | Cancer Commons | 300 | 2026-03-30 | 2026-10-08 |
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Neoplasm Metastasis (115) · Neoplasms (108) · Carcinoma, Non-Small-Cell Lung (48) · Pancreatic Neoplasms (32) · Breast Neoplasms (26) · Melanoma (26) · Colorectal Neoplasms (24) · Stomach Neoplasms (22) · Lung Neoplasms (19) · Ovarian Neoplasms (19) · Pain (17) · Lymphoma (16) · Squamous Cell Carcinoma of Head and Neck (16) · Uterine Cervical Neoplasms (15) · Colonic Neoplasms (14)
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M.D. Anderson Cancer Center (66) · Eli Lilly and Company (30) · Bristol-Myers Squibb (23) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (14) · University Health Network, Toronto (14) · Dana-Farber Cancer Institute (8) · Duke University (8) · Mirati Therapeutics Inc. (8) · Agenus Inc. (6) · Centre Leon Berard (6) · Massachusetts General Hospital (6) · Memorial Sloan Kettering Cancer Center (6) · Merck Sharp & Dohme LLC (6) · Alaunos Therapeutics (5) · Array Biopharma, now a wholly owned subsidiary of Pfizer (5)
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